Divergent Synthesis of Multisubstituted Hydroindole Derivatives via [3+2] Annulations of p‐Quinamines with Nitroalkenes
Hao Qin,
Didi Liu,
Bingrui Wan
et al.
Abstract:The synthesis of two stereoisomers of hydroindole derivatives was achieved through [3 + 2] annulations of p‐quinamines with nitroalkenes. Catalyst‐free or in the presence of DMAP, the annulation reactions were employed to produce the target products containing four contiguous stereogenic centers. This method enables efficient assessment of multisubstituted and functionalized hydroindole derivatives using readily accessible building blocks and reagents. Furthermore, the anti‐inflammatory activity of some result… Show more
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