Divergent selection for heat loss in mice: I. Selection applied and direct response through fifteen generations.

Nielsen, Marie Vejrup; Jones, L. D.; Freking, B. A.; DeShazer, J. A.

doi:10.2527/1997.7561461x

Cited by 70 publications

(95 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lines of mice used for this study were described by Nielsen et al (1997b) and represent the outcomes following divergent selection for heat loss. There were 3 criteria for selection: MH = selection for high heat loss, ML = selection for low heat loss, and maintenance control (MC) = unselected control.…”

Section: Experimental Animalsmentioning

confidence: 99%

Correlated responses in maternal performance following divergent selection for heat loss in mice1

McDonald

Nielsen

2006

Journal of Animal Science

View full text Add to dashboard Cite

Divergent selection in mice was applied in 3 independent replicates for high (maintenance high; MH) and low (maintenance low; ML) heat loss for 16 generations. An unselected control (maintenance control; MC) was also maintained in all replicates. Selection ceased for 26 generations; heat-loss measurement and selection resumed at generation 42. Lactation performance, dam weight, dam feed intake, and efficiency of production of pup weight were recorded or calculated for MH and ML dams in all 3 replicates at generation 46 or 47 with the objective of determining whether selection for heat loss has created correlated responses in maternal performance. One-half of the dams reared their own litters, and one-half reared cross-fostered (across lines) litters. Between 10 and 12 litters were used from each replicate-line-rearing class. Litter size was recorded, and litters were standardized to 8 pups within 24 h of birth. For cross fostering, MH litters were matched to ML litters born within 24 h of each other, and MH-ML litter pairs were cross-fostered at 3 d of age. A weigh-suckle-weigh protocol was used to obtain milk production estimates over a 2-h suckling period at 6, 9, 12, and 15 d. Dam (plus litter) feed intake

show abstract

Section: Experimental Animalsmentioning

confidence: 99%

Correlated responses in maternal performance following divergent selection for heat loss in mice1

McDonald

Nielsen

2006

Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Heat loss was measured over a single 15-h period using direct calorimetry. Realized responses in heat production after 15 generations of selection and the realized heritability are presented in a companion report (Nielsen et al, 1997). The objectives of this research were to measure the correlated responses in feed intake, body mass, body composition, and litter size at birth and its components that have accompanied selection for heat loss.…”

Section: Introductionmentioning

confidence: 99%

Divergent selection for heat loss in mice: II. Correlated responses in feed intake, body mass, body composition, and number born through fifteen generations.

Nielsen

Freking

Jones

et al. 1997

Journal of Animal Science

Self Cite

View full text Add to dashboard Cite

ABSTRACT:Divergent selection for heat loss (kcal·kg −.75 ·d −1 ) , measured in 9-to 11-wk-old male mice, was conducted for 15 generations. Selection for high (MH) and low (ML) heat loss and unselected control (MC) occurred in each of three replicates for a total of nine unique lines. Feed intake in males was measured during Generations 9 through 15. Body mass at commencement of mating in females and at time of measurement of heat loss in males was recorded. Body fat percentage at 12 wk for animals of Generations 6, 10, and 14 was predicted as a function of electrical conductivity and body mass. Litter size was recorded for all generations, and components of litter size were evaluated at Generation 11 in one replicate and Generation 12 in the other two replicates. Feed intake changed in the same direction as heat loss for the MH and ML selections; at Generation 15, the difference between MH and ML ( P < .002) was 20.6% of the MC mean. Body mass did not change with selection for heat loss. Differences in body fat percentage were not significant in earlier generations, but at Generation 14, MH and ML were significantly ( P < .01) different with MH mice having the lowest fat percentage; MC was intermediate. Selection had a significant (MH vs ML; P < .01) effect on litter size, causing an increase in MH and a decrease in ML. This difference was explained by a difference ( P < .01) in ovulation rate. There was no asymmetry of response in feed intake, fatness, litter size, or number of ovulations.

show abstract

“…All characters were measured in over 2000 mice from an advanced intercross population derived from a cross of lines originally selected for low (ML) and high (MH) heat loss [41,42]. This population was developed for an eventual fine mapping analysis of QTL, and it was useful to first estimate heritabilities and genetic correlations to serve as a basis for comparison with the QTL results.…”

Section: Introductionmentioning

confidence: 99%

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice

et al. 2005

View full text Add to dashboard Cite

-We estimated heritabilities and genetic correlations for a suite of 15 characters in five functional groups in an advanced intercross population of over 2000 mice derived from a cross of inbred lines selected for high and low heat loss. Heritabilities averaged 0.56 for three body weights, 0.23 for two energy balance characters, 0.48 for three bone characters, 0.35 for four measures of adiposity, and 0.27 for three organ weights, all of which were generally consistent in magnitude with estimates derived in previous studies. Genetic correlations varied from −0.65 to +0.98, and were higher within these functional groups than between groups. These correlations generally conformed to a priori expectations, being positive in sign for energy expenditure and consumption (+0.24) and negative in sign for energy expenditure and adiposity (−0.17). The genetic correlations of adiposity with body weight at 3, 6, and 12 weeks of age (−0.29, −0.22, −0.26) all were negative in sign but not statistically significant. The independence of body weight and adiposity suggests that this advanced intercross population is ideal for a comprehensive discovery of genes controlling regulation of mammalian adiposity that are distinct from those for body weight.advanced intercross mice / body weight / genetic correlations / heritability / obesity

show abstract

Divergent selection for heat loss in mice: I. Selection applied and direct response through fifteen generations.

Cited by 70 publications

References 16 publications

Correlated responses in maternal performance following divergent selection for heat loss in mice1

Correlated responses in maternal performance following divergent selection for heat loss in mice1

Divergent selection for heat loss in mice: II. Correlated responses in feed intake, body mass, body composition, and number born through fifteen generations.

Genetic variance and covariance patterns for body weight and energy balance characters in an advanced intercross population of mice

Contact Info

Product

Resources

About