Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

Pickering, Bradley; Lung, Oliver; Maguire, Finlay; Kruczkiewicz, Peter; Kotwa, Jonathon D.; Buchanan, Tore; Gagnier, Marianne; Guthrie, Jennifer L.; Jardine, Claire M.; Marchand-Austin, Alex; Massé, Ariane; McClinchey, Heather; Nirmalarajah, Kuganya; Aftanas, Patryk; Blais-Savoie, Juliette; Chee, Hsien-Yao; Chien, Emily; Yim, Winfield; Banete, Andra; Griffin, Bryan D.; Yip, Lily; Goolia, Melissa; Suderman, Matthew; Pinette, Mathieu; Smith, Greg; Sullivan, Daniel; Rudar, Josip; Vernygora, Oksana; Adey, Elizabeth; Nebroski, Michelle; Goyette, Guillaume; Finzi, Andrés; Laroche, Geneviève; Ariana, Ardeshir; Vahkal, Brett; Côté, Marceline; McGeer, Allison; Nituch, Larissa A.; Mubareka, Samira; Bowman, Jeff

doi:10.1038/s41564-022-01268-9

Cited by 114 publications

(49 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Strain tracking by whole genome sequencing evidenced a mink-selected SARS-CoV-2 lineage, named Cluster 5, which has further spilled-back to humans ( 46 , 57 ). Additionally, the transmission of a highly divergent SARS-CoV-2 strain (B.1.641) from a white-tailed deer to humans was recently suspected in Canada ( 58 ).…”

Section: Surveillance In Wildlifementioning

confidence: 99%

“…However, detection of the virus allows for genome sequencing, which improves understanding of how SARS-CoV-2 evolves in animals ( 78 , 79 ). Indeed, inter-species transmission and evolution in new hosts can also result in viral diversity, as seen during the human-mink-human transmission of SARS-CoV-2 ( 35 ) and the sustained transmission of the virus in the white-tailed deer populations ( 58 ).…”

Section: Surveillance In Wildlifementioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 and animals, a long story that doesn't have to end now: What we need to learn from the emergence of the Omicron variant

Alessandro

Rugna²,

Bonilauri³

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

OIE, the world organization for animal health, recently released an update on the state of the art of knowledge regarding SARS-CoV-2 in animals. For farmed animals, ferrets and minks were found to be highly susceptible to the virus and develop symptomatic disease both in natural conditions and in experimental infections. Lagomorphs of the species Oryctolagus cuniculus are indicated as highly susceptible to the virus under experimental conditions, but show no symptoms of the disease and do not transmit the virus between conspecifics, unlike raccoon dogs (Nyctereutes procyonoides), which in addition to being highly susceptible to the virus under experimental conditions, can also transmit the virus between conspecifics. Among felines, the circulation of the virus has reached a level of cases such as sometimes suggests the experimental use of vaccines for human use or treatments with monoclonal antibodies. But even among wild animals, several species (White-tailed deer, Egyptian rousettes, and minks) have now been described as potential natural reservoirs of the virus. This proven circulation of SARS-CoV-2 among animals has not been accompanied by the development of an adequate surveillance system that allows following the evolution of the virus among its natural hosts. This will be all the more relevant as the surveillance system in humans inevitably drops and we move to surveillance by sentinels similar to the human flu virus. The lesson that we can draw from the emergence of Omicron and, more than likely, its animal origin must not be lost, and in this mini-review, we explain why.

show abstract

Section: Surveillance In Wildlifementioning

confidence: 99%

Section: Surveillance In Wildlifementioning

confidence: 99%

SARS-CoV-2 and animals, a long story that doesn't have to end now: What we need to learn from the emergence of the Omicron variant

Alessandro

Rugna²,

Bonilauri³

2022

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Of note, SARS-CoV-2 exhibits a broad host tropism with varying efficiency in using ACE2 orthologs from different bats and mammals 26,[31][32][33] . Adaptive mutations of the RBD region can occur when circulating in humans and other hosts [34][35][36] .…”

Section: Introductionmentioning

confidence: 99%

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

Xiong

et al. 2022

Preprint

View full text Add to dashboard Cite

Phylogenetically distant coronaviruses have evolved to employ ACE2 as their common receptors, including NL63 and many Severe acute respiratory syndrome (SARS) coronavirus-related viruses. Recently, we found two Middle East respiratory syndrome coronaviruses (MERS-CoV)-related bat coronaviruses, NeoCoV and PDF-2180, also use Angiotensin-converting enzyme 2(ACE2) but not MERS-CoV receptor dipeptidyl peptidase 4 (DPP4) for entry. Receptor binding domain (RBD)-binding and pseudovirus entry assays based on a wide range of bat ACE2 orthologs revealed that the two viruses strongly prefer ACE2 from Yangochiropteran bats as compared with Yinpterochiropteran bats, which is not observed in NL63 and SARS-CoV-2. Genetic and structural analyses of the virus-receptor interactions of 50 bat ACE2 orthologs pointed to four crucial host range determinants in two viral binding loops on ACE2. Subsequent functional verifications via mutagenesis on representative ACE2 orthologs confirmed the importance of these determinants on human and bat cells. Remarkably, NeoCoV-T510F, a mutation previously shown to acquire human ACE2 recognition, displayed an expanded potential host range covering most tested bat ACE2, probably due to its reinforced interaction with an evolutionary conserved hydrophobic pocket. Our results elucidated the molecular mechanisms for the species-specific ACE2 usage of MERS-related viruses, offering basic information for assessing the zoonotic risk of these ACE2 utilizing merbecoviruses.

show abstract

“…In addition to natural infection, transmission to animals of the same species under experimental or natural conditions has been reported in mink, hamsters, white-tailed deer, cats, ferrets, and deer mice [ 2 , 3 , 4 , 5 , 6 , 7 ]. Confirmed or suspected transmission from animals to humans has been reported in farmed mink, hamsters, white-tailed deer, and a domestic cat [ 8 , 9 , 10 , 11 ]. As the number of naturally infected species with SARS-CoV-2 continues to increase, the establishment of a natural reservoir host in susceptible domestic or wild animals is of growing concern.…”

Section: Introductionmentioning

confidence: 99%

One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah

Cossaboom

Wendling

Lewis

et al. 2022

Viruses

View full text Add to dashboard Cite

From July–November 2020, mink (Neogale vison) on 12 Utah farms experienced an increase in mortality rates due to confirmed SARS-CoV-2 infection. We conducted epidemiologic investigations on six farms to identify the source of virus introduction, track cross-species transmission, and assess viral evolution. Interviews were conducted and specimens were collected from persons living or working on participating farms and from multiple animal species. Swabs and sera were tested by SARS-CoV-2 real-time reverse transcription polymerase chain reaction (rRT-PCR) and serological assays, respectively. Whole genome sequencing was attempted for specimens with cycle threshold values <30. Evidence of SARS-CoV-2 infection was detected by rRT-PCR or serology in ≥1 person, farmed mink, dog, and/or feral cat on each farm. Sequence analysis showed high similarity between mink and human sequences on corresponding farms. On farms sampled at multiple time points, mink tested rRT-PCR positive up to 16 weeks post-onset of increased mortality. Workers likely introduced SARS-CoV-2 to mink, and mink transmitted SARS-CoV-2 to other animal species; mink-to-human transmission was not identified. Our findings provide critical evidence to support interventions to prevent and manage SARS-CoV-2 in people and animals on mink farms and emphasizes the importance of a One Health approach to address emerging zoonoses.

show abstract

Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission

Cited by 114 publications

References 93 publications

SARS-CoV-2 and animals, a long story that doesn't have to end now: What we need to learn from the emergence of the Omicron variant

SARS-CoV-2 and animals, a long story that doesn't have to end now: What we need to learn from the emergence of the Omicron variant

Broad host tropism of ACE2-using MERS-related coronaviruses and determinants restricting viral recognition

One Health Investigation of SARS-CoV-2 in People and Animals on Multiple Mink Farms in Utah

Contact Info

Product

Resources

About