Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment

Liu, Juman; Chen, Yinhui; Zhang, Feng; Peng, Xi; Mao, Xiaoning; Lu, Wenlian; Wu, Ruijian; Huang, Binglong; Bao, Yanmin; Ma, Lian; Huang, Yuge; Zhang, Xingliang

doi:10.1159/000507250

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…It has been shown that miRNA-3162-3p is associated with the increased production of active beta-catenin, intensifying the inflammatory process and hyperreactivity of the airways. The use of anti-miRNA-3162-3p was compared in the use of dexamethasone and resulted in the inhibition of the Wnt/beta-catenin pathway [55,56]. Similar results between the target Wnt/beta-catenin pathway and miRNA-3162-3p were observed in mice lung cells for miRNA-943-3p, and the antagomir application of this molecule [57].…”

Section: Mirnas and Pathways Responsible For The Development Of Asthm...mentioning

confidence: 73%

miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

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Asthma is a chronic inflammatory disease of the airways characterized by shortness of breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 years), miRNAs and their role in asthma have been of constant interest among scientists. These small, non-coding RNA fragments, 18–25 nucleotides long, regulate gene expression at the post-transcriptional level by binding to the target mRNA. In this way, they affect several biological processes, e.g., shaping airway structures, producing cytokines and immune mediators, and controlling defense mechanisms. Publications confirm their potential role in the diagnosis and monitoring of the disease, but only some articles address the use of miRNAs in the treatment of asthma. The following paper reviews the latest available studies and presents miRNAs as a useful tool for predicting the effectiveness of the included treatment, early diagnosis of exacerbations, and in assessing patient compliance for different groups of drugs used in asthma. The latest known pathways underlying the pathogenesis of the disease, which are associated with a change in miRNA expression, may be precise targets of therapeutic activity in the future.

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Section: Mirnas and Pathways Responsible For The Development Of Asthm...mentioning

confidence: 73%

miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

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“…As shown in Figure 2, as the severity of AZ progressed, The research reported, the expression of miR-21 was upregulated in the lungs of mice stimulated with ovalbumin (OVA) compared to unstimulated mice, pulmonary eosinophils and mucus production were reduced in OVA-treated miR-21 knockout (KO) mice (17)(18)(19), furthermore, OVAtreated miR-21 KO mice showed markedly reduced bronchial hyperresponsiveness. MiR-21 may play a key role in Th2-related allergic conditions by regulating Th2 cells and cytokines (20)(21)(22). The miR-21 expression in CAMP was raised than that in healthy control children, at the cutoff value of 3.5, the sensitivity and specificity of miRNA-21 to distinguish CAMP from control children were 83%…”

Section: Blood Micro-rnas According To Az Severitymentioning

confidence: 94%

Blood miR-21 and miR-26 tailor a good diagnostic model for childhood asthma

Lidang Lu,

Guozhong Zheng,

Yuanjing Lin

2023

Cell Mol Biol (Noisy-le-grand)

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This study was to investigate the relationships between blood miR-21/26a with the prevalence and severity of childhood asthma (CAMP). For this purpose, 123 children with allergic asthma (AZ) from June 2018 to June 2020, and 60 contemporaneous healthy children for reference, were enrolled. Lung function was detected using a portable pediatric spirometer and AZ severity was evaluated. Blood samples of admissions were collected to quantify the expression degrees of miR-21 and miR-26a. Logistic regression analysis and model were constructed. Results showed that (1) CAMP had higher MiR-21 expression and lower MiR-26a expression than healthy controls; (2) The severity of AZ, evidenced by FEV1/PV, significantly correlated with miR-21(Y=-3.825X+102.6, P<0.001) and miR-26a (Y=10.43X+54.29, P<0.001); (3) The prevalence of AZ-related to miR-21 (OR=4.180, P<0.001) and miR-26a (OR=0.058, P<0.001) after adjusting for cofounders. (4) the expression levels of miR-21/26a had a good diagnostic potential for AZ (AUC are 0.85 and 0.94, respectively). In conclusion, Blood miRNA-21 and miR-26a are promising biomarkers for the diagnosis and severity of CAMP.

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“…Further research has shown that the blood level of miR-3162-3p was significantly higher in children with asthma than in healthy children [ 34 ]. Inhibition of miR-3162-3p in OVA-induced asthmatic mice could effectively alleviate airway inflammation and bronchial hyperresponsiveness, decrease β-catenin expression, maintain Th1/Th2 balance and inhibit airway remodeling [ 34 ]. When allergic airway inflammation occurs, miR-1165-3p plays an effective role by targeting IL-13 and protein phosphatase, Mg2 + /Mn2 + -dependent 1A (PPM1A).…”

Section: Mirnas In Asthmamentioning

confidence: 99%

Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma

et al. 2021

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Asthma is a chronic inflammatory disease characterized by airway remodeling and bronchial hyperresponsiveness. A variety of effector cells and cytokines jointly stimulate the occurrence of inflammatory response in asthma. Although the pathogenesis of asthma is not entirely clear, the possible roles of non-coding RNAs (ncRNAs) have been recently demonstrated. NcRNAs are nonprotein-coding RNA molecules, such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), which are involved in the regulation of a variety of biological processes. Mounting studies have shown that ncRNAs play pivotal roles in the occurrence and progression of asthma via competing endogenous RNA (ceRNA) regulatory networks. However, the specific mechanism and clinical application of ncRNAs and ceRNA regulatory networks in asthma have not been fully elucidated, which are worthy of further investigation. This paper comprehensively summarized the current progress on the roles of miRNAs, lncRNAs, circRNAs, and ceRNA regulatory networks in asthma, which can provide a better understanding for the disease pathogenesis and is helpful for identifying novel biomarkers for asthma.

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Divergent Roles of miR-3162-3p in Pulmonary Inflammation in Normal and Asthmatic Mice as well as Antagonism of miR-3162-3p in Asthma Treatment

Cited by 6 publications

References 26 publications

miRNAs as Modern Biomarkers in Asthma Therapy

miRNAs as Modern Biomarkers in Asthma Therapy

Blood miR-21 and miR-26 tailor a good diagnostic model for childhood asthma

Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma

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