Abstract:Epithelium-derived alarmin cytokines, thymic stromal lymphopoietin (TSLP), Interleukin (IL)-33, and IL-25, polarize T cells toward the T H 2 phenotype at barrier sites to fight pathogens and allergens (Hammad and Lambrecht, 2015). T H 2 cells are increasingly recognized as key players in barrier repair to prevent tissue damage following environmental insults like parasite infection (Chen et al., 2012). Furthermore, TSLP-induced T H 2 cell immunity is critical for suppressing epithelial tumor development in mic… Show more
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