Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

Wong, Ching; Yusta, Bernardo; Koehler, Jacqueline A.; Baggio, Laurie L.; McLean, Brent A.; Matthews, Dianne; Seeley, Randy J.; Drucker, Daniel J.

doi:10.1016/j.cmet.2022.08.003

Cited by 36 publications

(17 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been recently reported that the GLP-1 receptor of the IELs is required for the physiological function of GLP-1 in modulating the luminal microbiota composition and alleviating intestinal inflammation. 59 In this study, in the colonic inflammation state, the BSEF supplementation markedly upregulated the expression of Glp1r in the colons of mice with colitis. This result suggests the possible stimulatory effects of BS-ellagitannins on the intestinal cells involved in GLP-1 function as well as GLP-1 production.…”

Section: Resultsmentioning

confidence: 57%

Anti-inflammatory activities of black raspberry seed ellagitannins and their structural effects on the stimulation of glucagon-like peptide-1 secretion and intestinal bitter taste receptors

Kim

Lee

Lee³

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 57%

Anti-inflammatory activities of black raspberry seed ellagitannins and their structural effects on the stimulation of glucagon-like peptide-1 secretion and intestinal bitter taste receptors

Kim

Lee

Lee³

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Currently, the role of the inflammatory response in promoting the pathological processes in T2DM and its impact on affected tissues and organs is well recognized. Several studies have provided insights into the mechanisms by which T2DM induces inflammation and oxidative stress. – It is indisputably beneficial to modulate the inflammatory response in T2DM patients. – The cardiovascular, renal, and other organ-protective effects of novel antidiabetic medications have been attributed to their anti-inflammatory properties . Colonic inflammation, with its detrimental effects on the mucosal barrier, bacterial infection, and insulin resistance, has been implicated in various diseases, including diabetes.…”

Section: Discussionmentioning

confidence: 99%

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Li,

Duan,

Wang

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Inulin, a commonly used dietary fiber supplement, is capable of modulating the gut microbiome. Chronic inflammation resulting from metabolic abnormalities and gut flora dysfunction plays a significant role in the development of type 2 diabetes mellitus (T2DM). Our research has demonstrated that inulin administration effectively reduced colonic inflammation in T2DM mice by inducing changes in the gut microbiota and increasing the concentration of butyric acid, which in turn modulated the function of enteric glial cells (EGCs). Experiments conducted on T2DM mice revealed that inulin administration led to an increase in the Bacteroidetes/Firmicutes ratio and the concentration of butyric acid in the colon. The anti-inflammatory effects of altered gastrointestinal flora and its metabolites were further confirmed through fecal microbiota transplantation. Butyric acid was found to inhibit the activation of the κB inhibitor kinase β/nuclear factor κB pathway, regulate the expression levels of interleukin-6 and tumor necrosis factor-α, suppress the abnormal activation of EGCs, and prevent the release of inflammatory factors by EGCs. Similar results were observed in vitro experiments with butyric acid. Our findings demonstrate that inulin, by influencing the intestinal flora, modifies the activity of EGCs to effectively reduce colonic inflammation in T2DM mice.

show abstract

“… 125 Activation of glucagon-like peptide-1 (GLP-1) in intestinal IELs is closely related to the composition of the gut microbiota and the inflammatory state on the intestinal epithelial surface. 126 The aryl-hydrocarbon receptor (AhR) is required for the maintenance of IELs and inhibition of AhR prevents lipid peroxidative stress and iron death in IELs. 127 It is reported that activation of AhR can reduce the AP-induced inflammation by inducing the expression of IL-22, suggesting that activation of IELs by AhR mediated may be a new direction to protect against SAP-ALI.…”

Section: Composition Of the Intestinal Mucosal Immune Barriermentioning

confidence: 99%

Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis

Li,

Wang,

Cao

et al. 2024

JIR

View full text Add to dashboard Cite

The pathogenesis of severe acute pancreatitis-associated acute lung injury (SAP-ALI), which is the leading cause of mortality among hospitalized patients in the intensive care unit, remains incompletely elucidated. The intestinal mucosal immune barrier is a crucial component of the intestinal epithelial barrier, and its aberrant activation contributes to the induction of sustained pro-inflammatory immune responses, paradoxical intercellular communication, and bacterial translocation. In this review, we firstly provide a comprehensive overview of the composition of the intestinal mucosal immune barrier and its pivotal roles in the pathogenesis of SAP-ALI. Secondly, the mechanisms of its crosstalk with gut microbiota, which is called gut-lung axis, and its effect on SAP-ALI were summarized. Finally, a number of drugs that could enhance the intestinal mucosal immune barrier and exhibit potential anti-SAP-ALI activities were presented, including probiotics, glutamine, enteral nutrition, and traditional Chinese medicine (TCM). The aim is to offer a theoretical framework based on the perspective of the intestinal mucosal immune barrier to protect against SAP-ALI.

show abstract

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

Cited by 36 publications

References 104 publications

Anti-inflammatory activities of black raspberry seed ellagitannins and their structural effects on the stimulation of glucagon-like peptide-1 secretion and intestinal bitter taste receptors

Anti-inflammatory activities of black raspberry seed ellagitannins and their structural effects on the stimulation of glucagon-like peptide-1 secretion and intestinal bitter taste receptors

Inulin Inhibits the Inflammatory Response through Modulating Enteric Glial Cell Function in Type 2 Diabetic Mellitus Mice by Reshaping Intestinal Flora

Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis

Contact Info

Product

Resources

About