Divergent Mechanistic Pathways for Copper(I) Hydrophosphination Catalysis: Understanding that Allows for Diastereoselective Hydrophosphination of a Tri-substituted Styrene
Abstract:Readily available and bench-stable Cu(acac)2 (1) addresses many challenges in exploratory hydrophosphination catalysis. Mechanistic investigations were performed to answer questions that remain about the reactivity of 1, the role of light in the catalysis, and to provide direction for further study. A divergent Hammett plot indicates differing mechanisms based on electron density at the alkene substrate. A radical process was eliminated based on trapping reactions and in-situ EPR experiments. Isotopic labeling… Show more
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