Divergent mechanical properties of older human male femora reveal unique combinations of morphological and compositional traits contributing to low strength

Bolger, Morgan W; Romanowicz, Genevieve E.; Bigelow, Erin M.R.; Ward, Ferrous S.; Ciarelli, Antonio; Jepsen, Karl J.; Kohn, David H.

doi:10.1016/j.bone.2022.116481

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Cortical bone loss may also be correlated with parallel bone decline, which is not detected by HR‐pQCT but increases bone fragility, e.g., trabecular structural decline or the deterioration of the bone matrix or mineral lattice. ( 36 )…”

Section: Discussionmentioning

confidence: 99%

“…They reflect overall bone strength and do not account for bone morphology or composition. (36) Low aBMD and poor bone microarchitecture are associated with higher fracture risk. (5)(6)(7)(8)(9) The repeated measures allow for the assessment of bone loss on bone fragility.…”

Section: Discussionmentioning

confidence: 99%

“…Cortical bone loss may also be correlated with parallel bone decline, which is not detected by HR-pQCT but increases bone fragility, e.g., trabecular structural decline or the deterioration of the bone matrix or mineral lattice. (36) The improvement in fracture prediction by repeated DXA measures is not certain. The precision of DXA or HR-pQCT versus individual changes is poor.…”

Section: Discussionmentioning

confidence: 99%

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Rapid Cortical Bone Loss at the Distal Radius Is Associated With Higher Risk of Fracture in Older Men – The STRAMBO Study

Gunsing

Wagner

Whittier

et al. 2020

Journal of Bone and Mineral Research

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Rapid loss of areal bone mineral density (aBMD) is associated with higher fracture risk after adjustment for confounders including initial aBMD. However, the link between bone microarchitecture decline and fracture is not clear. We studied the association between bone microarchitecture deterioration assessed prospectively over 4 years and the subsequent fracture risk in older men. Bone microarchitecture at the distal radius and tibia was assessed by high-resolution peripheral QCT (HR-pQCT; XtremeCT, Scanco Medical) (baseline, 4 years) in 732 men aged 60-87 years. During the 8-year follow-up, 109 men had fragility fractures. Areal BMD was assessed by dual-energy X-ray absorptiometry. After adjustment for age, weight, prior falls and fractures, distal radius aBMD (baseline, slope), and baseline distal radius total volumetric BMD (Tt.BMD), a faster decrease in distal radius Tt.BMD was associated with higher fracture risk (hazard ratio [HR] = 1.54/SD, 95% confidence interval: 1.20-1.95, p < .005). Rapid cortical bone loss was associated with higher fracture risk

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Section: Discussionmentioning

confidence: 99%