Divergent effects of an α2-adrenergic antagonist on lipolysis and thermogenesis: Interactions with a β3-adrenergic agonist in rats

Gómez-Ambrosi, Javier; Frühbeck, G; Aguado, Miriam; Fi, Milagro; Margareto, Javier; Aj, Martínez

doi:10.3892/ijmm.8.1.103

Cited by 11 publications

(12 citation statements)

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“…Instead, inhibition of ␣-AR signaling may underlie the lipolytic effect of CST given its ability to prevent phenylephrine from activating PLC. Existing literature indicates that ␣-AR signaling inhibits lipolysis, whereas ␣-AR blockade potentiates the lipolytic effect of ␤-AR signaling (29,30,63,64). Acting like an ␣-AR antagonist, CST enhanced the lipolytic effect of ␤-AR agonists (Fig.…”

Section: Discussionmentioning

confidence: 95%

Catestatin (Chromogranin A352–372) and Novel Effects on Mobilization of Fat from Adipose Tissue through Regulation of Adrenergic and Leptin Signaling

Bandyopadhyay

Gentile

et al. 2012

Journal of Biological Chemistry

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Background: Mice lacking the neurosecretory protein Chromogranin A are obese, presumably because of resistance to catecholamines and leptin. Results: Catestatin (CST) reduces adiposity, an effect likely mediated by restoring leptin sensitivity and modulating adrenergic signaling. Conclusion: CST promotes lipolysis by blocking ␣-AR signaling and stimulating fatty acid oxidation. Significance: We propose CST as a candidate antiobesity agent.

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Section: Discussionmentioning

confidence: 95%

Catestatin (Chromogranin A352–372) and Novel Effects on Mobilization of Fat from Adipose Tissue through Regulation of Adrenergic and Leptin Signaling

Bandyopadhyay

Gentile

et al. 2012

Journal of Biological Chemistry

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“…The α 2 ‐AR antagonist, delequamine, readily evoked an increase in rat tail temperature with a small decrease in core temperature 33 . The administration of yohimbine, an α 2 ‐AR antagonist, produced a marked decrease in body temperature in rats and blocked the thermogenic effect of β 3 ‐AR agonist when simultaneously adminstered 34 . The blockade of serotonin‐5HT2A receptor suppressed sympathetically mediated cutaneous vasoconstriction in rats 35,36 .…”

Section: Discussionmentioning

confidence: 99%

“…33 The administration of yohimbine, an ␣2-AR antagonist, produced a marked decrease in body temperature in rats and blocked the thermogenic effect of ␤3-AR agonist when simultaneously adminstered. 34 The blockade of serotonin-5HT2A receptor suppressed sympathetically mediated cutaneous vasoconstriction in rats. 35,36 Therefore, the machinery for resisting the decline in body temperature is supposedly triggered by the risperidone injection.…”

Section: Discussionmentioning

confidence: 99%

Resistance to Excessive Bodyweight Gain in Risperidone‐injected Rats

Ota

Mori

Nakashima

et al. 2005

Clin Exp Pharma Physio

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1. The present study was carried out to explain the resistance of rats injected subcutaneously with risperidone, the atypical antipsychotic drug, for 21 consecutive days at 0.1 mg/kg per day (a dose equivalent to the one used for patients) to result in an excessive bodyweight despite the increase in diet-uptake in rats against risperidone-induced decrease in body temperature. 2. Rectal temperature measurements were made in 8-week-old male Sprague-Dawley rats maintained under standard laboratory conditions using a 12 h daylight cycle. A s.c. injection of risperidone (0.05 mg/kg) produced hypothermia in rats, which was observed during the daily injection for 21 consecutive days. 3. Sera, white and brown adipose tissues, skeletal muscle and liver were extracted from 8-week-old male Sprague-Dawley rats injected subcutaneously with risperidone (0.01 or 0.1 mg/kg per day) or a vehicle for 21 consecutive days. Serum levels of lipids, ketones and thyroid hormone were measured. The mRNA expression levels in these tissues and organs of the genes encoding the substances involved in heat production and/or lipid metabolism were investigated by using quantitative real-time polymerase chain reaction amplification. 4. Serum nonesterified fatty acid levels in risperidone 0.1 mg/kg per day s.c. injected rats were significantly lower than those in vehicle-injected ones. Serum beta-hydroxybutyrate levels in risperidone-injected rats tended to decrease compared with those in vehicle-injected ones. The serum level of neither triiodothyronine nor thyroxine was affected by risperidone s.c. injection at the doses examined, although their values were within normal limits. 5. Risperidone injection (0.1 mg/kg per day) for 21 consecutive days upregulated mRNA expressions in white adipose tissue of uncoupling protein 3 which dissipates energy as heat; peroxisome proliferator-activated receptor (PPAR) gamma coactivator 1alpha which activates mitochondrial biogenesis to expand the oxidative machinery; and PPARalpha which is necessary for the fat-depletion of adipocytes for thermogenesis. The mRNA of lipogenic enzymes (acetyl-CoA carboxylase alpha, fatty-acid synthase and glycerol-3-phosphate acyltransferase), hormone sensitive lipase and beta1-adrenoceptor were also enhanced in white adipose tissue by the injection of 0.1 mg/kg per day risperidone. 6. These findings suggest that the materials for heat generation in white adipose tissue would be readily supplied, which in turn would reduce a storage of lipids in white adipose tissue resulting in the lower rate of bodyweight gain of rats.

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“…Considering the whole experimental group, the parameter that was best able to explain the variance in wV O 2 and, therefore, in the energy expenditure, was BAT weight. In fact, it is well known that facultative thermogenesis is an important component of energy expenditure in rodents (57), with overall V O 2 being tightly correlated to BAT V O 2 (19).…”

Section: Resultsmentioning

confidence: 99%

Sex-related differences in energy balance in response to caloric restriction

Valle

Català-Niell

Colom

et al. 2005

American Journal of Physiology-Endocrinology and Metabolism

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related differences in energy balance were studied in young Wistar rats fed standard chow pellets either ad libitum or in restricted amounts (60% of ad libitum intake) for 100 days. Caloric intake, indirect calorimetry, organ and adipose tissue weights, energy efficiency, liver mitochondrial respiration rate, and brown adipose tissue (BAT) uncoupling protein-1 (UCP1) content were measured. Ad libitum-fed females showed greater oxygen consumption (V O2) and carbon dioxide production (V CO2) and lower energy efficiency than males. Caloric restriction induced a chronic drop of V O2 and V CO2 in females but not in males over the period studied. Restricted females showed a better conservation of metabolic active organ mass and a greater decrease in adipose depots than restricted males. Moreover, changes of BAT size and UCP1 content suggest that BAT may be the main cause responsible for sex differences in the response of energy balance to caloric restriction. In conclusion, our results indicate that females under caloric restriction conditions deactivate facultative thermogenesis to a greater degree than males. This ability may have obvious advantages for female survival and therefore the survival of the species when food is limiting. brown adipose tissue; sexual dimorphism; uncoupling protein-1; oxygen consumption ENERGY BALANCE DEPENDS ON THE MECHANISMS that regulate and coordinate food intake and the different components of energy expenditure, including basal metabolism, physical activity, and heat production. When food is in short supply, caloric intake is lower than energy expenditure, resulting in a negative energy balance (25). Caloric restriction (CR) is a frequent condition in nature; hence, throughout evolution, organisms have evolved mechanisms to respond and adapt to energy restriction. Several studies have reported that CR and starvation have a consistently greater effect on physical growth in males than in females (10,23,25,26,29,63,64). Furthermore, important sex-associated differences have been found in the response of white adipose mass to CR. These studies suggest that females use energy stored as fat to a greater extent than males (26, 44). However, the loss of lean body mass cannot wholly explain the energy conservation seen when female rats are subjected to CR (26).Restriction of physical activity could be another strategy to improve energy efficiency. Nevertheless, CR rats are as active as ad libitum-fed rats, indicating that they are not economizing their energy by restricting their activity (16,24,38,43).Another possibility to explain changes in energy efficiency related to sex implies differences in heat production. In rodents, nonshivering thermogenesis takes place mainly in brown adipose tissue (BAT), where thermogenesis activity depends on uncoupling protein-1 (UCP1), an inner-membrane mitochondrial protein expressed characteristically in this tissue, the function of which is to dissipate, as heat, the proton gradient energy generated by the respiratory chain (7, 48). These particular energ...

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Divergent effects of an α2-adrenergic antagonist on lipolysis and thermogenesis: Interactions with a β3-adrenergic agonist in rats

Cited by 11 publications

References 0 publications

Catestatin (Chromogranin A352–372) and Novel Effects on Mobilization of Fat from Adipose Tissue through Regulation of Adrenergic and Leptin Signaling

Catestatin (Chromogranin A352–372) and Novel Effects on Mobilization of Fat from Adipose Tissue through Regulation of Adrenergic and Leptin Signaling

Resistance to Excessive Bodyweight Gain in Risperidone‐injected Rats

Sex-related differences in energy balance in response to caloric restriction

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