Divergent cellular pathways of hippocampal memory consolidation and reconsolidation

Lee, Jonathan; Hynds, Robert E.

doi:10.1002/hipo.22083

Cited by 62 publications

(58 citation statements)

References 59 publications

(94 reference statements)

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“…Indeed, BDNF regulates mTOR-dependent translation (Takei et al, 2004) and controls the local synthesis of plasticity related proteins such as CaMKII, Arc, Homer 2 and GluR1 (Schratt, Nigh, Chen, Hu, & Greenberg, 2004;Slipczuk et al, 2009;Yin, Edelman, & Vanderklish, 2002), which are functionally linked to memory reconsolidation (Chia & Otto, 2013;Rich et al, 2016). Some reports, dealing mainly with fear-motivated learning tasks, indicate that BDNF participates in memory consolidation but not reconsolidation (Lee, Everitt, & Thomas, 2004;Lee & Hynds, 2013;Schulz-Klaus, Lessmann, & Endres, 2013). However, this differential involvement of BDNF in memory processing does not seem to be a common property of all kind of memories.…”

Section: Discussionmentioning

confidence: 98%

BDNF controls object recognition memory reconsolidation

Radiske

Rossato

Gonzalez

et al. 2017

Neurobiology of Learning and Memory

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a-amanitinMuscimol Novelty Retrieval a b s t r a c t Reconsolidation restabilizes memory after reactivation. Previously, we reported that the hippocampus is engaged in object recognition memory reconsolidation to allow incorporation of new information into the original engram. Here we show that BDNF is sufficient for this process, and that blockade of BDNF function in dorsal CA 1 impairs updating of the reactivated recognition memory trace.

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Section: Discussionmentioning

confidence: 98%

BDNF controls object recognition memory reconsolidation

Radiske

Rossato

Gonzalez

et al. 2017

Neurobiology of Learning and Memory

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“…Contextual fear memory reconsolidation and extinction have both been demonstrated to be critically dependent upon NMDA receptor activity (Suzuki et al 2004;Lee and Hynds 2013;Lee and Flavell 2014). The bidirectional effect of the same amnestic treatment, dependent upon the parameters of memory reactivation, indicates that the dissociable effects are mediated by impairments in different mnemonic processes (Lee et al 2006; de la The null point in contextual fear reactivation www.learnmem.org Fuente et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…No footshock was applied at either reexposure or test sessions. The aversive response (freezing) was automatically quantified during all sessions with a videotracking software (Viewpoint Life Sciences), and used as a memory index (Lee and Hynds 2013;Song et al 2016).…”

Section: Contextual Fear Conditioningmentioning

confidence: 99%

On the transition from reconsolidation to extinction of contextual fear memories

et al. 2017

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Retrieval of an associative memory can lead to different phenomena. Brief reexposure sessions tend to trigger reconsolidation, whereas more extended ones trigger extinction. In appetitive and fear cued Pavlovian memories, an intermediate "null point" period has been observed where neither process seems to be engaged. Here we investigated whether this phenomenon extends to contextual fear memory. Adult rats were subjected to a contextual fear conditioning paradigm, reexposed to the context 2 d later for 3, 5, 10, 20, or 30 min, with immediate injections of MK-801 or saline following reexposure, and tested on the following day. We observed a significant effect of MK-801 with the 3-and 30-min sessions, impairing reconsolidation and extinction, respectively. However, it did not have significant effects with 5-, 10-, or 20-min sessions, even though freezing decreased from reexposure to test. Further analyses indicated that this is not likely to be due to a variable transition point at the population level. In conclusion, the results show that in contextual fear memories there is a genuine "null point" between the parameters that induce reconsolidation and extinction, as defined by the effects of MK-801, although NMDA receptor-independent decreases in freezing can still occur in these conditions.[Supplemental material is available for this article.]The retrieval of an associative memory can result in different outcomes. Retrieval in the absence of further reinforcement can destabilize a memory, requiring a process of reconsolidation (Nader and Hardt 2009), or can cause memory extinction through new inhibitory learning (Giustino and Maren 2015). The balance between destabilization and extinction appears to be influenced by the relative strength of learning and extent of nonreinforced retrieval (Eisenberg et al. 2003;Suzuki et al. 2004;Lee et al. 2006;de la Fuente et al. 2011;Flavell and Lee 2013). More extensive stimulus reexposure (i.e., extinction training), or weaker initial conditioning is more likely to result in extinction, whereas more restricted stimulus reexposure preferentially engages memory destabilization. This apparent competition between destabilization and extinction manifests as a bidirectional effect of amnestic treatment, depending of the parameters of conditioning and retrieval. Either reconsolidation is impaired to reduce subsequent memory expression, or extinction is disrupted to maintain expression of the original memory (Eisenberg et al. 2003;Suzuki et al. 2004;Lee et al. 2006;de la Fuente et al. 2011;Flavell and Lee 2013).In both appetitive Pavlovian and conditioned fear memories, recent evidence has indicated that extinction per se does not prevent memory destabilization and reconsolidation. In cue-sucrose, cue-fear, and context-fear settings, there appears to be a reexposure period between the parameters that engage destabilization and extinction, in which there is no behavioral effect of amnestic treatment (Flavell and Lee 2013;Merlo et al. 2014;Alfei et al. 2015). This "limbo" or "null poin...

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“…In light of our current findings, it may be tentatively suggested that exercise not only enhances BDNF, but may impact upon other brain transcription factors, such as Zif268 and upstream factors of de novo protein synthesis, where diverging pathways of hippocampal contextual fear memory consolidation and reconsolidation have been observed. It has been demonstrated that the dissociation between BDNF and Zif268 expression in memory consolidation and reconsolidation extends to the selective requirement for separate plasticity-associated gene expression of MEK and IKKa protein kinases, respectively, and a common involvement of NMDA receptors (Lee and Hynds 2013).…”

Section: Discussionmentioning

confidence: 99%

A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation

2014

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Three experiments used rats to examine the effect of a single bout of voluntary activity (wheel running) on the acquisition, extinction, and reconsolidation of context conditioned fear. In Experiment 1, rats provided with access to a wheel for 3 h immediately before or after a shocked exposure to a context froze more when tested in that context than rats provided with access to the wheels 6 h after the shocked exposure or rats not provided with access to the wheels. In Experiment 2, rats provided with access to the wheels immediately before or after a nonshocked exposure to the conditioned context froze less when tested in that context than rats provided with access to the wheels 6 h after the nonshocked exposure or rats not provided with access to the wheels. In Experiment 3, rats provided with access to wheels immediately after an extended nonshocked exposure to the conditioned context again froze less, whereas rats provided with access to the wheels after a brief nonshocked exposure froze more on the subsequent test than sedentary controls. These results show that a single bout of running can enhance acquisition, extinction, and reconsolidation of context conditioned fear.Pavlovian conditioned fear is thought to contribute to anxiety disorders such as post-traumatic stress, and extinction of this fear is a goal of exposure-based treatments of post-traumatic stress disorder (Bouton et al. 2001). Hence, there has been interest in identifying variables that regulate the acquisition and extinction of fear responses in animal models in order to better understand posttraumatic stress and develop more effective treatments for this disorder. One of the variables that influence the acquisition of conditioned fear in rodents is a history of exercise. Rodents provided with access to running wheels for several weeks and then shocked in a distinctive context exhibit more fear (typically freezing responses) than sedentary controls (Baruch et al.

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Divergent cellular pathways of hippocampal memory consolidation and reconsolidation

Cited by 62 publications

References 59 publications

BDNF controls object recognition memory reconsolidation

BDNF controls object recognition memory reconsolidation

On the transition from reconsolidation to extinction of contextual fear memories

A bout of voluntary running enhances context conditioned fear, its extinction, and its reconsolidation

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