Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model
Jente R. A. Boen,
Andreas B. Gevaert,
Amélie Dendooven
et al.
Abstract:AimsMiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of diastolic dysfunction, and evaluated additional effects on kidney as relevant comorbid organ.Methods and resultsDiastolic dysfunction was induced in male C57/BL6J mice (n = 20) by combining high-fat diet, L-NG-nitroarginine methyl ester, and angiotensin II admin… Show more
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