Divergent associations of drinking frequency and binge consumption of alcohol with mortality within the same cohort

Graff-Iversen, Sidsel; Jansen, Mona Dverdal; Hoff, Dominic Anthony; Høiseth, Gudrun; Knudsen, Gun Peggy; Magnus, Per; Mørland, Jörg; Normann, Per T.; Næss, Øyvind; Tambs, Kristian

doi:10.1136/jech-2012-201564

Cited by 35 publications

(30 citation statements)

References 19 publications

(26 reference statements)

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“…Among Finnish men, those who consumed six or more drinks per drinking occasion showed increased total mortality compared to those without such a pattern, independent of overall alcohol consumption (Kauhanen et al, 1997;Laatikainen et al, 2003). Further, among Norwegians ages 20-62 years, drinking five drinks or more per occasion, even when infrequent, was linked to increased 20-year total mortality (Graff-Iversen et al, 2013). Similarly, among U.S. adults 17 years of age and older followed for 9 years, drinking five or more drinks a day at any frequency predicted increased total mortality risk (Plunk et al, 2014).…”

Section: Heavy Episodic Drinking and Mortalitymentioning

confidence: 89%

Drinking Level, Drinking Pattern, and Twenty-Year Total Mortality Among Late-Life Drinkers

Schutte

Brennan

Holahan

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective: Research on moderate drinking has focused on the average level of drinking. Recently, however, investigators have begun to consider the role of the pattern of drinking, particularly heavy episodic drinking, in mortality. The present study examined the combined roles of average drinking level (moderate vs. high) and drinking pattern (regular vs. heavy episodic) in 20-year total mortality among late-life drinkers. Method: The sample comprised 1,121 adults ages 55-65 years. Alcohol consumption was assessed at baseline, and total mortality was indexed across 20 years. We used multiple logistic regression analyses controlling for a broad set of sociodemographic, behavioral, and health status covariates. Results: Among individuals whose high level of drinking placed them at risk, a heavy episodic drinking pattern did not increase mortality odds compared with a regular drinking pattern. Conversely, among individuals who engage in a moderate level of drinking, prior findings showed that a heavy episodic drinking pattern did increase mortality risk compared with a regular drinking pattern. Correspondingly, a high compared with a moderate drinking level increased mortality risk among individuals maintaining a regular drinking pattern, but not among individuals engaging in a heavy episodic drinking pattern, whose pattern of consumption had already placed them at risk. Conclusions: Findings highlight that low-risk drinking requires that older adults drink low to moderate average levels of alcohol and avoid heavy episodic drinking. Heavy episodic drinking is frequent among late-middle-aged and older adults and needs to be addressed along with average consumption in understanding the health risks of late-life drinkers. (J. Stud. Alcohol Drugs, 76, 552-558, 2015) Received: January 15, 2015. Revision: March 12, 2015. This work was supported by National Institute on Alcohol Abuse and Alcoholism Grant AA15685 and by Department of Veterans Affairs Health Services Research and Development Service funds. The opinions expressed here are the authors' and do not necessarily represent the opinions of the Department of Veterans Affairs. *Correspondence may be sent to Charles J. Holahan at the Department of Psychology (A8000), University of Texas at Austin, Austin, TX 78712, or via email at: holahan@utexas.edu. E XCESSIVE ALCOHOL CONSUMPTION is a major risk factor for chronic disease and injury (Rehm et al., 2009), but moderate alcohol consumption has been associated with reduced total mortality (Di Castelnuovo et al., 2006). However, research on moderate drinking has focused on the average level of drinking, masking diverse underlying patterns of drinking (Naimi et al., 2013). Among individuals whose average consumption is moderate, drinking may vary from a regular pattern to occasions of heavy episodic drinking. Recently, investigators have begun to consider the role of drinking pattern in mortality (Roerecke et al., 2011;Wannamethee, 2013). Heavy episodic drinking and mortalityHeavy episodic drinking is linked t...

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Section: Heavy Episodic Drinking and Mortalitymentioning

confidence: 89%

Drinking Level, Drinking Pattern, and Twenty-Year Total Mortality Among Late-Life Drinkers

Schutte

Brennan

Holahan

et al. 2015

J. Stud. Alcohol Drugs

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“…There is evidence that heavy episodic (binge) drinking, which results in exposure of tissues to high levels of alcohol, is particularly harmful 81, 87, 88 . Binge drinking is generally defined as a man consuming 5 standard drinks within 2 hours; women are typically smaller and have a lower percentage of body water, so 4 standard drinks can reach similar alcohol levels.…”

Section: Genetics Of Alcohol-associated Diseasesmentioning

confidence: 99%

Genetics and alcoholism

Edenberg

Foroud

2013

Nat Rev Gastroenterol Hepatol

147

137

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Alcohol is widely consumed, but excessive use creates serious physical, psychological and social problems and contributes to many diseases. Alcoholism (alcohol dependence, alcohol use disorders) is a maladaptive pattern of excessive drinking leading to serious problems. Abundant evidence indicates that alcoholism is a complex genetic disease, with variations in a large number of genes affecting risk. Some of these genes have been identified, including two genes of alcohol metabolism, ADH1B and ALDH2, that have the strongest known affects on risk for alcoholism. Studies are revealing other genes in which variants impact risk for alcoholism or related traits, including GABRA2, CHRM2, KCNJ6, and AUTS2. As larger samples are assembled and more variants analyzed, a much fuller picture of the many genes and pathways that impact risk will be discovered.

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“…These alcohol-attributable costs exceed 1% of the gross national product of high-and middle-income countries, making pathological alcohol use one of the largest avoidable risk factors for the global burden of disease [1]. Studies have reported that alcohol use is associated with cardiovascular disease (CVD), although there is debate about these conclusions [2][3][4][5][6][7][8]. However, there is the lack of updated information that specifically examines the status of alcohol consumption in China, which has been experiencing rapid economic progress and epidemiologic transitions that are often associated with an increase in CVD [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Alcohol consumption and cardiovascular diseases in rural China

Zhao

Bai

Guo

et al. 2016

International Journal of Cardiology

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Divergent associations of drinking frequency and binge consumption of alcohol with mortality within the same cohort

Abstract: Questions on drinking frequency and a specific question on binge drinking capture different effects of alcohol use on all-cause and CVD mortality.

Cited by 35 publications

References 19 publications

Drinking Level, Drinking Pattern, and Twenty-Year Total Mortality Among Late-Life Drinkers

Drinking Level, Drinking Pattern, and Twenty-Year Total Mortality Among Late-Life Drinkers

Genetics and alcoholism

Alcohol consumption and cardiovascular diseases in rural China

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