Divergence of protein sensing (TLR 4, 5) and nucleic acid sensing (TLR 3, 7) within the reptilian lineage

Priyam, Manisha; Tripathy, Mamta; Rai, Umesh; Ghorai, Soma Mondal

doi:10.1016/j.ympev.2017.11.018

Cited by 5 publications

(3 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significance level was set at P < .05 for the FEL, IFEL, MEME, and SLAC analyses; a posterior probability of >0.9 was used for FUBAR. A site was considered to be under selection if it was identified as such by >1 of the algorithms [29][30][31]. This was done to account for the uncertainty in whether random-effects models or counting methods are more reliable for detecting selection [32][33][34].…”

Section: Selection Pressure Analysismentioning

confidence: 99%

Multiple Class I and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

Grant

González-Beiras

Amick

et al. 2018

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

Section: Selection Pressure Analysismentioning

confidence: 99%

Multiple Class I and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

Grant

González-Beiras

Amick

et al. 2018

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Differential evolution of TLRs has been reported both, within the receptor as well as between the receptors. The TIR domain shows a higher degree of conservation in comparison to the extracellular ligand recognition domain in species from various vertebrate classes [5][6][7][8] .…”

mentioning

confidence: 99%

Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus

Priyam

Gupta

Sarkar

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

The high degree of conservation of toll-like receptors (TLRs), and yet their subtle variations for better adaptation of species in the host–pathogen arms race make them worthy candidates for understanding evolution. We have attempted to track the trend of TLR evolution in the most diverse vertebrate group—teleosts, where Clarias batrachus was given emphasis, considering its traits for terrestrial adaptation. Eleven C. batrachus TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 22, 25, 26) were identified in this study which clustered in proximity to its Siluriformes relative orthologues in the phylogenetic analysis of 228 TLRs from 25 teleosts. Ten TLRs (TLR1, 2, 3, 5, 7, 8 9, 13, 21, 22) with at least 15 member orthologues for each alignment were processed for selection pressure and coevolutionary analysis. TLR1, 7, 8 and 9 were found to be under positive selection in the alignment-wide test. TLR1 also showed maximum episodic diversification in its clades while the teleost group Eupercaria showed the maximum divergence in their TLR repertoire. Episodic diversification was evident in C. batrachus TLR1 and 7 alignments. These results present a strong evidence of a divergent TLR repertoire in teleosts which may be contributing towards species-specific variation in TLR functions.

show abstract

“…Beyond these few studies, literature on actual cell functionality in vitro is sparse, and much more work needs to be done to truly understand T cell function and cell-mediated immunity in reptiles. With advancements in genomic studies, characterization of genes such as those in the TLR family are the becoming the targets of study (Priyam, Tripathy, Rai, & Ghorai, 2018). Hopefully, future work will yield more reagents to determine whether differing immunophenotypes exist within the reptilian system, such as separate T cell populations.…”

Section: │Cell-mediated Immunitymentioning

confidence: 99%

Out of the Shell: Exploring The Phagocytic Capabilities of the B Cell and Isolated Lymphoid Follicle-lie Structures in the Red-Eared Slider, Trachemys Scripta

Ashford¹

View full text Add to dashboard Cite

I would first like to thank both of my Co-PIs, Dr. Laura Vogel and Dr. Rachel Bowden for giving me the opportunity to work with them on this wonderful journey into the realm of research and turtles. This work would not have been possible without their endless amounts of support and encouragement. The door to their offices were always open whenever I ran into trouble in the lab or had a question about my research or writing. Secondly, I would like to thank all of my past and present lab members for their contributions both in the lab and out in the field;

show abstract

Divergence of protein sensing (TLR 4, 5) and nucleic acid sensing (TLR 3, 7) within the reptilian lineage

Cited by 5 publications

References 49 publications

Multiple Class I and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

Multiple Class I and Class II Haemophilus ducreyi Strains Cause Cutaneous Ulcers in Children on an Endemic Island

Variation in selection constraints on teleost TLRs with emphasis on their repertoire in the Walking catfish, Clarias batrachus

Out of the Shell: Exploring The Phagocytic Capabilities of the B Cell and Isolated Lymphoid Follicle-lie Structures in the Red-Eared Slider, Trachemys Scripta

Contact Info

Product

Resources

About