Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage

Ebina, Yasuhiko; Shimada, Shigeki; Deguchi, Masashi; Maesawa, Yoko; Iijima, Norifumi; Yamada, Hideto

doi:10.1111/aji.12546

Cited by 20 publications

(18 citation statements)

References 20 publications

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“…1,8 It is therefore not surprising that Treg cell levels in decidua are low in inevitable spontaneous abortion of normal karyotype embryos compared to normal levels in elective termination decidua and in decidua associated with abnormal karyotype embryos. 11 So is missed abortion a distinct entity unrelated to the pathogenesis of spontaneous abortion, or are there factors in missed abortions that prevent progression to clinical abortion? 1,8 By contrast, in the decidua of missed abortion cases, which have not become inevitable, with a normal karyotype embryo Ebina et al reported an increase in Foxp3 + CD4 + CD25 high Tregs and an increase in CD8 + IFNγ + "effector" T cells.…”

Section: Introductionmentioning

confidence: 99%

“…1,8 By contrast, in the decidua of missed abortion cases, which have not become inevitable, with a normal karyotype embryo Ebina et al reported an increase in Foxp3 + CD4 + CD25 high Tregs and an increase in CD8 + IFNγ + "effector" T cells. 11 So is missed abortion a distinct entity unrelated to the pathogenesis of spontaneous abortion, or are there factors in missed abortions that prevent progression to clinical abortion?…”

Section: Introductionmentioning

confidence: 99%

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Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis

Clark

Dmetrichuk

McCready

et al. 2017

American J Rep Immunol

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis

Clark

Dmetrichuk

McCready

et al. 2017

American J Rep Immunol

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“…It was reported that Treg migration from the peripheral blood toward the decidua decreases in cases of miscarriage with a normal or abnormal embryo karyotype (49,50). Also an intrinsic deficiency in peripheral blood Tregs in RPL is associated with diminished IL-2 and TGF-β secretion whereas decidual Tregs have elevated interferon (IFN)-γ expression (51). Tregs that express insufficient FOXP3, due to polymorphisms in the promoter region, may be phenotypically plastic and convert into Th17 and then could directly contribute to the pathology.…”

Section: Discussionmentioning

confidence: 99%

VIP Promotes Recruitment of Tregs to the Uterine–Placental Interface During the Peri-Implantation Period to Sustain a Tolerogenic Microenvironment

et al. 2020

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“…Migration of CD8 + T lymphocytes to the decidua is facilitated by an increase in the expression of CXCR3 [21] and CCR5 [63,93]. CXCR3 ligands produce decidual stromal cells: CXCL9 (MIG), CXCL10 (IP-10), CXCL11 (I-TAC) [30]. CXCL9 is expressed in the placenta and in the chorioamniotic membrane, is found in the bloodstream, and the increased production of this molecule is associated with premature delivery and low foetal weight [29,62,65,105,115].…”

Section: Differentiation Of Cd8 + T Lymphocytesmentioning

confidence: 99%

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

Степанова¹,

Bazhenov²,

Khokhlova³

et al. 2018

Med. immunol.

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At the present time, a broad spectrum of CD8+ T lymphocyte subsets is revealed, including naïve cells, memory cells and regulatory subpopulations. Along with cells with high cytolytic activity, some subsets with marked regulatory activity were found there. Each subpopulation is characterized by a set of produced mediators, surface and intracellular markers allowing to suggest their differential in vivo functional activity. The present review article proposes a classification of CD8+ Т cells which takes into account their morphological and functional features. According to conventional view, the CD8+ Т lymphocytes is a cell population exhibiting high cytotoxic ability which is of critical significance in pregnancy, under the conditions of semi-allogenic fetal cell invasion into the endometrium. The fraction of CD8+ T cells is rather high in decidual structures. The review discusses the known mechanisms of differentiation regulation, selective migration and activity of CD8+ T cells in decidual membrane and placenta in the course of pregnancy. Perforine and granzyme are the main cytotoxicity factors of CD8+ Т cells. IL-2, IL-5, IL-13, IFNγ, IL-17, TGF-β and IL-10 cytokines are considered regulatory mediators of CD8+ cells. To induce the effector properties of CD8+ T cells, an antigenic stimulation is required, which is provided by interactions between the CD8+ Т cells and activated CD4+ Т cells or dendritic cells, cytokine effects. Specific differentiation of the CD8+ T cells is determined by differences in microenvironvent. In the course of pregnancy, accumulation of CD8+ Т cells is observed in decidual membrane, but their phenotype and functional properties differ from CD8+ Т cells in peripheral blood. At present time, the mechanisms of selective CD8+ T cell migration to decidual membrane are studied. These events are suggested to be mediated by means of CXCR3 and CCR5 chemokine receptors, IL-6 and IL-15 cytokines. The features of CD8+ Т cell activities, and production of some cytokines, e.g., CSF2, IFNγ, IL-1β, IL-2, IL-6, IL-8,IL-10, IL-12 and TNFα in decidual membrane and is of critical significance for effective invasion of trophoblast cells. In turn, the trophoblast and placental cells promote development of regulatory CD8+ Т lymphocytes in decidual membrane, being able to induce CD8+ T cell apoptosis in decidual membrane. Hence, interaction between the maternal CD8+ T cells and trophoblast in the area of uterine-placental contact is an important link during development of immunological tolerance in the maternal/fetal system.

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Divergence of helper, cytotoxic, and regulatory T cells in the decidua from miscarriage

Abstract: Activation of IFN-γ(+) Tc and Treg cells in the decidua might be associated with the pathophysiology underlying MN.

Cited by 20 publications

References 20 publications

Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis

Changes in expression of theCD200 tolerance‐signaling molecule and its receptor (CD200R) by villus trophoblasts during first trimester missed abortion and in chronic histiocytic intervillositis

VIP Promotes Recruitment of Tregs to the Uterine–Placental Interface During the Peri-Implantation Period to Sustain a Tolerogenic Microenvironment

The Role of Subpopulations of Cd8+ T Lymphocytes in the Development of Pregnancy

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