Objective-To propose medial rectus (MR) recession to be equally as effective as lateral rectus (LR) resection, which has heretofore been the preferred treatment for divergence paralysis esotropia (DPE).Methods-We examined a 17-year surgical experience comparing LR resection with MR recession in adults with DPE, defined as symptomatic distance esotropia (ET) at least double the asymptomatic ET of 10 or less prism diopters (Δ) at near.Results-Twenty-four patients with DPE underwent surgery. Six patients underwent bilateral LR resection and 2 underwent unilateral LR resection (group L), while 13 underwent bilateral MR recession and 3 underwent unilateral MR recession, with the target angle double the distance ET (group M). One of 8 patients in group L and 15 of 16 patients in group M underwent intraoperative adjustable surgery under topical anesthesia. Mean (SD) preoperative central gaze ET measured 15.0 (7.7) Δ at distance and 4.1 (3.4) Δ at near in group L, but 10.4 (6.8) Δ at distance and 0.6 (1.7) Δ at near in group M (P=.15; distance, 0.003, near). Postoperatively, no patient in either group had symptomatic diplopia or convergence insufficiency in follow-up from 8.5 to 40 months. Twice the usual surgical dose of MR recession per prism diopter was required to achieve correction of the distance deviation in DPE as compared with that recommended for ET generally and also for LR resection in the same condition.Conclusions-Recession of the MR provides binocular single vision in DPE without convergence insufficiency at near, and it is convenient for intraoperative adjustment under topical anesthesia.Divergence paralysis esotropia (DPE)-variably termed divergence insufficiency, divergence insufficiency esotropia, and divergence paresis esotropia-is characterized by comitant esotropia (ET) at distance fixation associated with symptomatic diplopia, fusion at near fixation, and normal saccadic velocities in adduction and abduction. As the name implies, early thinking about DPE was dominated by the presumed pathophysiological concept of a brain lesion involving a putative divergence center. 1,2 Indeed, isolated clinical reports have associated DPE with neurologic conditions such as brain tumors, multiple sclerosis, trauma, subdural hematoma, and tertiary syphilis. [2][3][4][5] Even postulated as a cause of DPE was increased medial rectus (MR) muscle tonicity as a compensatory mechanism for © 2012 American Medical Association Correspondence: Joseph L. Demer, MD, PhD, Jules Stein Eye Institute, University of California, Los Angeles, 100 Stein Plaza, Los Angeles, CA 90095-7002 (jld@ucla.edu). Author Contributions: Both authors had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. 8 Therefore, it has most recently been proposed that DPE is more typically a mechanical rather than a neurogenic disorder. Although based on the modern proposal for etiology, the term DPE has become a misnomer; it is used here as a convenience for reference...