Divergence Between Stone Composition and Urine Supersaturation: Clinical and Laboratory Implications

Lingeman, James E.; Kahnoski, Richard J.; Mardis, Hal K.; Goldfarb, David S.; Grasso, Michael; Lacy, Sushil S.; Scheinman, Steven J.; Asplin, John R.; Parks, Joan H.; Coe, Fredric L.

doi:10.1016/s0022-5347(01)61594-5

Cited by 15 publications

(11 citation statements)

References 11 publications

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“…Free ionic concentrations and ionic strength are estimated [12]. In adults, supersaturation measurements have been shown to accurately reflect kidney stone mineral composition, and supersaturation measurements have become commonplace as a tool to gauge recurrence risk and treatment adequacy [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Supersaturation calculations for the major stone-forming salts accurately reflect kidney stone mineral composition, and supersaturation values are useful in predicting risk of stone recurrence. Measurement of urine supersaturation has become a focus in the clinical evaluation of adults with urolithiasis [7,8], but experience in children is limited [6].…”

Section: Introductionmentioning

confidence: 99%

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Role of urinary supersaturation in the evaluation of children with urolithiasis

et al. 2005

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Timed urine collections are a standard part of the evaluation for predisposition to stone formation in children with urolithiasis. Supersaturation is defined as the ratio of the concentration of dissolved salt to its solubility in urine. The purpose of the present study was to determine if adding supersaturation to the standard timed urine collection increased the ability to detect a metabolic predisposition to stone formation. Thirty-two children with urolithiasis had 24-hour urine measurements of calcium, oxalate, citrate, uric acid, and cystine (the "traditional" evaluation), as well as supersaturation for calcium oxalate, calcium phosphate, and uric acid, on the same urine sample. Nine (28%) of the 32 were hypercalciuric, 2 (6%) hyperoxaluric, and 4 (12%) hypocitraturic. In total, 14 (44%) had a metabolic predisposition that was detected by the traditional evaluation. Supersaturation was elevated in 18 (56%), including nine who did not have metabolic predisposition detected by traditional evaluation. Urine volume was low in 17 (53%) of 32 children, including eight of nine children with abnormal supersaturation but normal traditional evaluation. Only one child with normal traditional evaluation and normal urine volume had elevated supersaturation. These results show that the benefit of adding supersaturation to the traditional evaluation was largely negated by consideration of urine volume.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of urinary supersaturation in the evaluation of children with urolithiasis

et al. 2005

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“…Despite this, the debate around the importance of SS is still heated [6,13,14]. We investigated the accuracy of 24-h SS in predicting corresponding stone type at different levels of predominant stone composition.…”

Section: Discussionmentioning

confidence: 99%

“…It is possible that the predictive role of urinary SS is dependent on timing of testing, as temporal stone-related dietary changes can present a distorted picture of the patients' propensity for stone formation. Further, this study is limited by inter-laboratory variability [14]; in our study, the stone analysis was done by single laboratory by infrared spectroscopy and the 24-h urine evaluation was performed by a single laboratory (Litholink, Chicago, IL).…”

Section: Discussionmentioning

confidence: 99%

Does 24-Hour Urine Supersaturation Predict Stone Composition?

Omar

Tarplin

Mahdy

et al. 2015

World J Nephrol Urol

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“…7 Because of the added expense and the shipping requirements, the supersaturation test may not be as readily available in all locations as traditional 24-hour urine chemistry analysis. The goal of our study was to test the hypothesis that traditional 24-hour urine levels of calcium, oxalate and phosphate are sufficiently sensitive and specific to preclude the need for urine supersaturation testing.…”

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confidence: 99%