Divalproex Sodium in Alcohol Withdrawal: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Reoux, Joseph P.; Saxon, Andrew J.; Malte, Carol A.; Baer, John; Sloan, Kevin L.

doi:10.1111/j.1530-0277.2001.tb02354.x

Cited by 98 publications

(28 citation statements)

References 23 publications

(16 reference statements)

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“…During the study, participants treated with zonisamide had less craving for alcohol, less anxiety, and less daytime sedation compared with participants treated with diazepam. Similar results have been reported in comparative studies between benzodiazepines (oxazepam, lorazepam) and anticonvulsants [5,13,14,17,35] . In another study with a similar design performed by our team, oxcarbazepine was found to have a similar effi cacy to diazepam in the prevention of epileptic seizures during alcohol detoxifi cation [19] .…”

Section: Outcomes During the Outpatient Period (Week 3)supporting

confidence: 86%

Zonisamide versus Diazepam in the Treatment of Alcohol Withdrawal Syndrome

Rubio¹,

López-Muñoz

Ponce³

et al. 2010

Pharmacopsychiatry

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Section: Outcomes During the Outpatient Period (Week 3)supporting

confidence: 86%

Zonisamide versus Diazepam in the Treatment of Alcohol Withdrawal Syndrome

Rubio¹,

López-Muñoz

Ponce³

et al. 2010

Pharmacopsychiatry

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“…In Kenya, Diazepam is commonly used. The use of anticonvulsants as a treatment for acute alcohol withdrawal has been investigated in several studies [31][32][33][34][35], as well as considered in two meta-analyses [36,37] and a review [38], and has been reported to be an effective agent during the period of detoxification.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with relapse and remission of alcohol dependent persons after community based treatment

Kuria¹

2013

OJPsych

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Knowledge of factors associated with relapse and remission after treatment for alcohol dependence enables the clinician to offer better individualized treatment. It also enables the clinician to predict which patients are likely to relapse and therefore offer appropriate and effective treatment to prevent relapse. Objective: This study sought to determine the factors associated with remission and relapse in a group of alcohol dependent persons undergoing Community Based Detoxification and Rehabilitation of alcohol dependent persons. Method: One hundred and eighty eight (188) persons with Alcohol Use Disorder Identification Test (AUDIT) positive were subjected to outpatient detoxification for 10 days using a pair of ampoules of high potency Vitamin B and C intravenously daily for 3 consecutive days, diazepam 5 mg and carbamazepine 200 mg for 5 and 10 consecutive nights respectively on an outpatient basis. The participants were visited twice a week (at home) by the community based health workers and reviewed once a week by the principal investigator and attended a bimonthly group therapy session conducted in groups of 20 s as part of the rehabilitation process. The groups were converted to self-help groups after 4 months to generate income for the participants. Results: Factors significantly associated with relapse to alcohol use included severity of alcohol use and craving for alcohol at intake and the age of onset of alcohol drinking. Further there was a statistically significant predictive value in the mean score of alcohol related problems in the community based group (health, social, financial and legal). Conclusion: Identifying factors that are associated with relapse after alcohol dependence treatment is likely to improve the effectiveness of treatment and prevent relapse in persons at risk.

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“…While benzodiazepines and barbiturates have been the primary treatment modality for alcohol withdrawal, 1,2 a growing number of clinical studies suggests that the anticonvulsants represent desirable alternatives 3–13 . Benzodiazepines and barbiturates have the disadvantages of respiratory depression, potential for drug‐drug interactions, and their own dependence liability.…”

mentioning

confidence: 73%

A Randomized, Open‐Label, Controlled Trial of Gabapentin and Phenobarbital in the Treatment of Alcohol Withdrawal

et al. 2006

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Gabapentin was compared with phenobarbital for the treatment of alcohol withdrawal in a randomized, open-label, controlled trial in 27 inpatients. There were no significant differences in the proportion of treatment completers between treatment groups or the proportion of patients in each group requiring rescue medication for breakthrough signs and symptoms of alcohol withdrawal. There were no significant treatment differences in withdrawal symptoms or psychological distress, nor were there serious adverse events. These findings suggest that gabapentin may be as effective as phenobarbital in the treatment of alcohol withdrawal. Given gabapentin's favorable pharmacokinetic profile, further study of its effectiveness in treating alcohol withdrawal is warranted.

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Divalproex Sodium in Alcohol Withdrawal: A Randomized Double‐Blind Placebo‐Controlled Clinical Trial

Abstract: This placebo-controlled pilot study suggests that divalproex sodium significantly affects the course of acute alcohol withdrawal and reduces the need for treatment with a benzodiazepine. A more aggressive loading dose strategy may demonstrate a more robust or earlier response.

Cited by 98 publications

References 23 publications

Zonisamide versus Diazepam in the Treatment of Alcohol Withdrawal Syndrome

Zonisamide versus Diazepam in the Treatment of Alcohol Withdrawal Syndrome

Factors associated with relapse and remission of alcohol dependent persons after community based treatment

A Randomized, Open‐Label, Controlled Trial of Gabapentin and Phenobarbital in the Treatment of Alcohol Withdrawal

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