Divalproex Sodium for the Treatment of PTSD and Conduct Disordered Youth: A Pilot Randomized Controlled Clinical Trial

Steiner, Hans; Saxena, Kirti; Carrión, Victor G.; Khanzode, Leena; Silverman, Melissa; Chang, Kiki

doi:10.1007/s10578-007-0055-8

Cited by 78 publications

(64 citation statements)

References 28 publications

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“…Divalproex sodium was reported to be effective for treating PTSD in a 7-week, doubleblinded, randomized, controlled clinical trial of 71 young patients (all males, mean age 16, SD 1.0) with conduct disorder, of whom 12 were suffering from PTSD [42]. Participants were randomized into either a high (between 500 and 1500 mg/day or therapeutic plasma levels for seizure control between 50 and 120 ng/ml) or low dose (up to 250 mg/day) condition.…”

Section: Reviews On Psychopharmacotherapy Of Ptsd Among Children and mentioning

confidence: 99%

Posttraumatic Stress Disorder in Children and Adolescents: A Review of Psychopharmacological Treatment

Huemer

Erhart

Steiner

2010

Child Psychiatry Hum Dev

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The current paper aims at reviewing studies on psychopharmacological treatment of childhood and adolescent PTSD. Additionally, developmental frameworks for PTSD diagnosis and research along with an experimental model of quenching and kindling in the context of stress exposure are presented. We conducted an extensive literature search of reviews on psychopharmacotherapy as well as studies on psychopharmacological treatment for PTSD among children and adolescents. We used the database PubMed and focused on the time period of the last 10 years up to January 2009. Pertinent earlier papers were also included.There are a limited number of studies specifically assessing the psychopharmacological treatment of PTSD in children and adolescents. The vast majority of them lack verification in RCTs. Only the use of imipramine, divalproex sodium and sertraline were already evaluated in RCTs. Future studies should take into account developmental approaches to the diagnosis and treatment of PTSD in children and adolescents. In this context, different underlying neurobiological patterns, which are reflected in distinct clinical symptomatology, require a precise investigation and a symptom-orientated psychopharmacological approach.

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Section: Reviews On Psychopharmacotherapy Of Ptsd Among Children and mentioning

confidence: 99%

Posttraumatic Stress Disorder in Children and Adolescents: A Review of Psychopharmacological Treatment

Huemer

Erhart

Steiner

2010

Child Psychiatry Hum Dev

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“…The same can be said for mood stabilizers such as carbamazepine, divalproex and oxcarbazepine, all of which have open label trial or retrospective case series evidence demonstrating that use of medication was associated with some improvement in PTSD symptoms. [43][44][45] …”

Section: Other Medicationsmentioning

confidence: 99%

Pharmacologic Considerations for Youth with Posttraumatic Stress Disorder

Keeshin

2017

J Korean Acad Child Adolesc Psychiatry

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Section: Mental Health Interventionsmentioning

confidence: 99%

“…50-53,57-59, 81,82,90,132 High-dose valproic acid treatment compared with low-dose treatment led to less illness severity in adolescent boys with conduct disorder. 132 In adult women with bipolar disease, the use of an algorithm for the treatment of bipolar disease improved medication utilization and adherence compared with usual care. 81,82 Osmotic release methylphenidate treatment in adult men with attention-deficit or hyperactivity disorder (ADHD) positively affected ADHD symptoms and psychosocial functioning compared with a placebo.…”

Section: Mental Health Interventionsmentioning

confidence: 99%

A Systematic Review of Randomized Controlled Trials of Interventions to Improve the Health of Persons During Imprisonment and in the Year After Release

et al. 2015

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We systematically reviewed randomized controlled trials of interventions to improve the health of people during imprisonment or in the year after release. We searched 14 biomedical and social science databases in 2014, and identified 95 studies.Most studies involved only men or a majority of men (70/83 studies in which gender was specified); only 16 studies focused on adolescents. Most studies were conducted in the United States (n = 57). The risk of bias for outcomes in almost all studies was unclear or high (n=91). In 59 studies, interventions led to improved mental health, substance use, infectious diseases, or health service utilization outcomes; in 42 of these studies, outcomes were measured in the community after release.Improving the health of people who experience imprisonment requires knowledge generation and knowledge translation, including implementation of effective interventions.Worldwide, more than 11 million people are imprisoned at any given time, and the prison population continues to grow at a rate faster than that of the general population. 1 Substantial evidence reveals that people who have experienced imprisonment have poor health compared with the general population, as indicated by the prevalence of mental illness, infectious diseases, chronic diseases, and mortality. 2 There are several reasons to focus on improving the health of people who experience imprisonment. 3 The burden of disease in this population affects the general population directly through increased health care costs and through the transmission of communicable diseases (e.g., HIV, HCV, and tuberculosis) after people are released from detention. Imprisonment has also been associated with worse health in family members of those who are detained, compared with the general population, including chronic diseases 4 and poor mental health 5,6 in adult relatives and mortality in male children. 7 At the community level, higher rates of incarceration have been associated with adverse health outcomes, such as sexually transmitted infections and teen pregnancies. 8 There is also evidence that poor health in persons who are released from detention, particularly those with inadequately treated mental illness and substance use disorders, 3 may affect public safety and reincarceration rates, 3 and that better access to health care is associated with less recidivism. 9,10 Finally, the right to health and health care is enshrined in international human rights documents, 11,12 and is a legislated responsibility of governments in many countries.Intervening during imprisonment and at the time of release could improve the health of people who experience imprisonment and public health overall. 13 To address this gap, we systematically reviewed randomized controlled trials of interventions to improve health in persons during imprisonment and in the year after release.We chose this population because we view imprisonment as a unique opportunity to deliver and to link with interventions for this population, and to highlight interventions t...

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Divalproex Sodium for the Treatment of PTSD and Conduct Disordered Youth: A Pilot Randomized Controlled Clinical Trial

Cited by 78 publications

References 28 publications

Posttraumatic Stress Disorder in Children and Adolescents: A Review of Psychopharmacological Treatment

Posttraumatic Stress Disorder in Children and Adolescents: A Review of Psychopharmacological Treatment

Pharmacologic Considerations for Youth with Posttraumatic Stress Disorder

A Systematic Review of Randomized Controlled Trials of Interventions to Improve the Health of Persons During Imprisonment and in the Year After Release

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