Diva vaccines that reduce virus transmission

Oirschot, J.T. van

doi:10.1016/s0168-1656(99)00121-2

Cited by 175 publications

(116 citation statements)

References 56 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Therefore, our findings of high cell-mediated and humoral responses after infection by the oronasal route reinforce the need to develop new strategies for vaccine improvement, specifically in view of the development of high cell mediated responses in the context of deleted or marker vaccines. Such vaccines are awaited for use under emergency conditions, to allow rapid discrimination between infected and vaccinated pigs [6,31]. Subunit vaccines were recently developed for that purpose [4] but proved to be of moderate efficacy under emergency [7,30].…”

Section: Discussionmentioning

confidence: 99%

Humoral and cell-mediated immune responses of d/d histocompatible pigs against classical swine fever (CSF) virus

et al. 2003

View full text Add to dashboard Cite

-A better understanding of cell-mediated immune responses to classical swine fever virus (CSFV) is essential for the future development of improved vaccines. We analyzed the generation of cell-mediated and humoral immune responses in d/d histocompatible pigs following CSFV infection or vaccination. Viral infection induced high T cell responses with high primary and secondary CTL activity correlated with high IFN-g production, whereas vaccination with a live vaccine followed by infection mainly induced neutralizing antibody but low cell-mediated responses. Moreover, high IgG1 response was associated with high IFN-g response following infection whereas a weak IFN-g response was related to a good IgG2 response but a low IgG1 production. These data could reflect Th1/Th2-like balance of immune responses depending upon immunization protocols, which has not yet been described in the pig. T-cell responses to CSFV were evidenced by CSFV-specific CD25 upregulation on CD4 -CD8 + , but not on CD4 + CD8 -cells, which further illustrated the importance of CTL responses after infection. Our results indicated that generation of cell-mediated immune responses was much higher following intranasal/oral CSFV infection than after intramuscular vaccination, which implies that the capacity of new CSFV vaccines to induce higher T-cell responses should be considered. immunity / cytotoxicity / CSFV / d/d histocompatible pig

show abstract

Section: Discussionmentioning

confidence: 99%

Humoral and cell-mediated immune responses of d/d histocompatible pigs against classical swine fever (CSF) virus

et al. 2003

View full text Add to dashboard Cite

show abstract

“…This makes seroepidemiological surveillance of the disease impossible in enzootic areas where a vaccination program has been or is being implemented. A way to combine both the activities, viz., vaccination and serosurveillance, for the better management of the disease would be the use of DIVA vaccines, which enable differentiation between infected and vaccinated animals [155]. Faris et al [52] conducted cross-sectional epidemiological study followed by vaccination with Nigeria 75/1 vaccine, produced at National Veterinary Institute (NVI) in Debre-Zeit, Ethiopia and postvaccinal serum antibody assessment against PPR in small ruminant population of Awash Fentale District, Afar, Ethiopia, during September 2006-June 2007.…”

Section: Prevention and Controlmentioning

confidence: 99%

Diagnosis and control of peste des petits ruminants: a comprehensive review

Balamurugan¹,

Hemadri²,

Gajendragad³

et al. 2013

VirusDis.

130

118

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is an acute, highly contagious, world organization for animal health (OIE) notifiable and economically important transboundary viral disease of sheep and goats associated with high morbidity and mortality and caused by PPR virus. PPR is considered as one of the main constraints in augmenting the productivity of small ruminants in developing countries and particularly severely affects poor farmer's economy. The disease is clinically manifested by pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhoea and bronchopneumonia. The disease can be diagnosed from its clinical signs, pathological lesions, and specific detection of virus antigen/antibodies/genome in the clinical samples by various serological tests and molecular assays. PPR is the one of the priority animal diseases whose control is considered important for poverty alleviation in enzootic countries. Availability of effective and safe live attenuated cell culture PPR vaccines and diagnostics have boosted the recently launched centrally sponsored control programme in India and also in other countries. This review article primarily focus on the current scenario of PPR diagnosis and its control programme with advancement of research areas that have taken place in the recent years with future perspectives.

show abstract

“…A number of inactivated and live attenuated vaccines are commercially available, but the latter are more commonly used because of the requirement for only one vaccine dose (reviewed in [18,19]). A vaccine using a virus containing a deletion of the gene encoding gE is widely used at present; in addition to being highly attenuated, this virus is incapable of reactivation and its use allows differentiation of infected from vaccinated animals based on detection of serological responses to gE [20]. Although live vaccines have proved to be relatively effective, concerns remain about their immunosuppressive activities and some of the most attenuated viruses have been reported to have reduced immunogenicity [20,21].…”

Section: Introductionmentioning

confidence: 99%

“…A vaccine using a virus containing a deletion of the gene encoding gE is widely used at present; in addition to being highly attenuated, this virus is incapable of reactivation and its use allows differentiation of infected from vaccinated animals based on detection of serological responses to gE [20]. Although live vaccines have proved to be relatively effective, concerns remain about their immunosuppressive activities and some of the most attenuated viruses have been reported to have reduced immunogenicity [20,21]. Hence, there is continued interest in the possibility of using subunit antigens for vaccination in some animal production sectors.…”

Section: Introductionmentioning

confidence: 99%

Identification of immediate early gene products of bovine herpes virus 1 (BHV-1) as dominant antigens recognized by CD8 T cells in immune cattle

Hart

MacHugh

Sheldrake

et al. 2017

Journal of General Virology

View full text Add to dashboard Cite

In common with other herpes viruses, bovine herpes virus 1 (BHV-1) induces strong virus-specific CD8 T-cell responses. However, there is a paucity of information on the antigenic specificity of the responding T-cells. The development of a system to generate virus-specific CD8 T-cell lines from BHV-1-immune cattle, employing Theileria-transformed cell lines for antigen presentation, has enabled us to address this issue. Use of this system allowed the study to screen for CD8 T-cell antigens that are efficiently presented on the surface of virus-infected cells. Screening of a panel of 16 candidate viral gene products with CD8 T-cell lines from 3 BHV-1-immune cattle of defined MHC genotypes identified 4 antigens, including 3 immediate early (IE) gene products (ICP4, ICP22 and Circ) and a tegument protein (UL49). Identification of the MHC restriction specificities revealed that the antigens were presented by two or three class I MHC alleles in each animal. Six CD8 T-cell epitopes were identified in the three IE proteins by screening of synthetic peptides. Use of an algorithm (NetMHCpan) that predicts the peptide-binding characteristics of restricting MHC alleles confirmed and, in some cases refined, the identity of the epitopes. Analyses of the epitope specificity of the CD8 T-cell lines showed that a large component of the response is directed against these IE epitopes. The results indicate that these IE gene products are dominant targets of the CD8 T-cell response in BHV-I-immune cattle and hence are prime-candidate antigens for the generation of a subunit vaccine.

show abstract

Diva vaccines that reduce virus transmission

Cited by 175 publications

References 56 publications

Humoral and cell-mediated immune responses of d/d histocompatible pigs against classical swine fever (CSF) virus

Humoral and cell-mediated immune responses of d/d histocompatible pigs against classical swine fever (CSF) virus

Diagnosis and control of peste des petits ruminants: a comprehensive review

Identification of immediate early gene products of bovine herpes virus 1 (BHV-1) as dominant antigens recognized by CD8 T cells in immune cattle

Contact Info

Product

Resources

About