Diurnal variations in the catecholamine content in rat tissues Effects of exogenous noradrenaline

Davidović, Vesna; Petrović, Vojislav M.

doi:10.3109/13813458109082642

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…According to this model, sympathetic outflow may control NAT activity and OEA synthesis in fat through local release of noradrenaline and/or elevation of circulating adrenaline. Supporting this role for the sympathetic nervous system, we also found that OEA levels follow a diurnal regulation in rat adipose tissue (2), which closely follows the diurnal variations of noradrenaline in WAT (26); although an enticing prediction, it remains to be determined whether sympathetic activity is indeed responsible for diurnal OEA fluxes.…”

Section: Discussionmentioning

confidence: 64%

Cold Exposure Stimulates Synthesis of the Bioactive Lipid Oleoylethanolamide in Rat Adipose Tissue

LoVerme

Guzmán

Gaetani

et al. 2006

Journal of Biological Chemistry

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Oleoylethanolamide (OEA) is an endogenous lipid mediator that inhibits feeding and stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activating receptor-␣. Little is known about the physiological regulation of this compound outside of the gastrointestinal tract, where its production is regulated by feeding. Here we show that cold exposure increases OEA levels in rat white adipose tissue but not in liver or intestine. This change is accompanied by parallel elevations in the activity of N-acyltransferase, a key enzyme responsible for OEA synthesis, without concomitant changes in fatty acid amide hydrolase, an enzyme responsible for OEA degradation. Moreover, cold stimulates the production of two species of N-oleoylphosphatidylethanolamine OEA precursors. The changes in OEA biosynthesis are reversed by pretreatment with the ␤-receptor antagonist propranolol, suggesting a role for ␤-adrenoreceptors in this response. In agreement with these findings, the ␤-agonists noradrenaline and isoproterenol stimulate OEA production in isolated adipocytes, an effect that is mimicked by the adenylyl cyclase activator forskolin. Collectively, these results identify cold exposure as a natural stimulus for OEA formation in white fat and suggest a role for the sympathetic nervous system in regulating OEA biosynthesis. The fatty acid ethanolamide (FAE)2 family of lipid mediators includes polyunsaturated species such as anandamide (1) and saturated or monounsaturated species such as oleoylethanolamide (OEA) (2, 3). Anandamide is an endogenous ligand for G-protein-coupled cannabinoid receptors (1), while OEA exerts a number of pharmacological effects, which include inhibition of feeding behavior (4) and stimulation of fatty acid mobilization and oxidation (5). These effects are thought to be mediated, at least in part, by activation of the nuclear receptor peroxisome proliferator-activating receptor type-␣ (PPAR-␣), because they are absent in PPAR-␣ null mice and are mimicked by synthetic PPAR-␣ agonists (5, 6). Despite the potential physiological significance of OEA, little is known about the natural stimuli that trigger the biosynthesis of this compound in vivo. In the small intestine of rodents (4, 6) and reptiles (7), OEA levels change in response to nutrient status: they are lower in fooddeprived than free-feeding animals and return to base-line values upon re-feeding (2,4,6,8). Moreover, in the brain (9) and white adipose tissue (WAT) (2), OEA levels fluctuate diurnally, although the physiological significance of these oscillations remains unknown.The biosynthesis of OEA, like that of other FAEs, is thought to occur through two sequential biochemical steps. The first consists in the transfer of a fatty acid residue from the sn-1 position of phosphatidylcholine to the free amine group of phosphatidylethanolamine (PE). This reaction is catalyzed by a Ca 2ϩ and cyclic AMP-regulated N-acyltransferase (NAT) activity, which yields a family of N-acylphosphatidylethanolamine (NAPE) species (1). The second rea...

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Section: Discussionmentioning

confidence: 64%

Cold Exposure Stimulates Synthesis of the Bioactive Lipid Oleoylethanolamide in Rat Adipose Tissue

LoVerme

Guzmán

Gaetani

et al. 2006

Journal of Biological Chemistry

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“…We have previously reported that CA content in the adrenals as well as in the IBAT of rats varies diurnally (DAVIDOVIC & PETROVIC, 1981). Besides, diurnal alteration of exogenous NA accumulation in the IBAT was found (DAVIDOVIC & PETROVIC, 1981) which is in correlation with diurnal rhythm of thermogenic action of this neurohormone (PETROVIC et al, 1976).…”

Section: Introductionmentioning

confidence: 96%

Influence of fasting and dopamine on the tissue catecholamines diurnal variations

Davidović

Petrović

Markovic

1988

Archives Internationales de Physiologie et de Biochimie

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2 figures)To define the role of catecholamines (CA) in the metabolic adaptation to fasting we examined the effect of exogenous dopamine(DA) on heat production(HP) and CA content in the interscapular brown adipose tissue(1BAT) and adrenals of controlfed and 2-day fasted rats in the morning(M) and in the evening(E).DA stimulates HP in fed rats in the M by 45% but the thermogenic effect of this CA is markedly higher in the E. However, DA had no thermogenic effect in fasted rats. The tissue CA in fed rats fluctuates diurnally : in the IBAT noradrenaline(NA) was much higher in the E while adrenaline(A) in adrenals was lower. DA in fed rats did not change the adrenal A but reduced NA content both in the adrenals and in the IBAT all over the day. Fasting depleted A from adrenals but increased NA content both in the M and in the E. Unlike the adrenals in the IBAT fasting did not affect NA content. In the adrenal gland of fasted rats DA significantly increased the A content to the equal degree during the day, while this CA had no effect on NA content of the IBAT. Archives of Physiology and Biochemistry Downloaded from informahealthcare.com by McMaster University on 12/27/14 For personal use only. VUKOSAVA DAVIDOVIC Institute of Physiology and Biochemistry, Faculty of Sciences, University of Belgrade Studentski trg 16, P. 0. Box 550, 11OOO Beograd, Yugoslavia. Archives of Physiology and Biochemistry Downloaded from informahealthcare.com by McMaster University on 12/27/14 For personal use only.

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“…This effect could be reversed in animals exposed to a reversed light cycle. A similar diurnal change in the content of norepinephrine in the heart and hypothalamus was observed by Davidovic and Petrovich (23). The present studies measuring electrical firing rate differ from those measuring norepinephrine turnover.…”

Section: Resultsmentioning

confidence: 36%

“…One possible explanation is that norepinephrine turnover and sympathetic firing rate may measure different functional characteristics of the sympathetic nervous system, and that they may be modified by eating patterns. Recent data from our laboratory (24) measuring the interaction oflight and food intake on the turnover of norepinephrine also reach conclusions different from those of Lemmer (23). We have found that sympathetic activity as measured by norepinephrine turnover is increased during the day and that there is a significant interaction of food intake and light (24).…”

Section: Resultsmentioning

confidence: 63%

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Diurnal changes in sympathetic activity. Relation to food intake and to insulin injected into the ventromedial or suprachiasmatic nucleus.

Takeo¹,

Takahashi²,

Bray³

1988

J. Clin. Invest.

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Diurnal variations in the catecholamine content in rat tissues Effects of exogenous noradrenaline

Cited by 7 publications

References 8 publications

Cold Exposure Stimulates Synthesis of the Bioactive Lipid Oleoylethanolamide in Rat Adipose Tissue

Cold Exposure Stimulates Synthesis of the Bioactive Lipid Oleoylethanolamide in Rat Adipose Tissue

Influence of fasting and dopamine on the tissue catecholamines diurnal variations

Diurnal changes in sympathetic activity. Relation to food intake and to insulin injected into the ventromedial or suprachiasmatic nucleus.

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