Diurnal Variations in Blood Chemical Items in Sprague-Dawley Rats.

Minematsu, Sumio; Watanabe, Masahiko; Tsuchiya, Naho; Watanabe, Masayuki; Amagaya, Sakae

doi:10.1538/expanim.44.223

Cited by 23 publications

(14 citation statements)

References 5 publications

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“…the dark than the light period, with a glucose utilization peak occurring at approximately 200 hours. 9,35 This corresponds somewhat with the peak degree of infarction noted in this study, suggesting that glucose availability may be a contributing factor. The fact that the animals were fed freely as opposed to fasting may have no bearing on glucose rhythmicity.…”

Section: Glucose As a Factorsupporting

confidence: 79%

Temporal changes in sensitivity of rats to cerebral ischemic insult

Vinall

Kramer²,

Heinel³

et al. 2000

Journal of Neurosurgery

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Section: Glucose As a Factorsupporting

confidence: 79%

Temporal changes in sensitivity of rats to cerebral ischemic insult

Vinall

Kramer²,

Heinel³

et al. 2000

Journal of Neurosurgery

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“…Similarly, Gerber and Erdman (1979) reported hypertriglyceridemia in rats consuming all-trans-RA at doses as low as 25 µg g −1 of diet (Gerber and Erdman, 1979) while no less than 315 µg g −1 diet of 13-cis-RA was required to produce similar effects (Gerber and Erdman, 1980). Many of these serum physiological markers of health in humans and experimental animals exhibit clear diurnal rhythms (Winkel et al, 1975;Pocock et al, 1989;Kanabrocki et al, 1990;Minematsu et al, 1995). Most studies which describe the effect of retinoic acids (RA) on serum chemistry have investigated a single time point.…”

Section: Introductionmentioning

confidence: 98%

Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

Cisneros¹,

Gough²,

Patton³

et al. 2005

J. Appl. Toxicol.

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Currently used to treat severe acne, 13-cis-retinoic acid (13-cis-RA) is under investigation for its anticancer effects as is the isomer, all-trans-retinoic acid (all-trans-RA). Here, the effects of oral 13-cis-RA or all-trans-RA treatment on serum chemistry, leptin and adiponectin levels were evaluated. Adult Sprague-Dawley rats were gavaged once daily for 7 consecutive days with 13-cis-RA (7.5 or 15 mg kg(-1)), all-trans-RA (10 or 15 mg kg(-1)) (n=24/sex/dose), or soy oil (n=16/sex) and blood was sampled 30-480 min after the last gavage. The body weight was unaffected; however, the liver/body weight ratios were increased by both doses of all-trans-RA. Sex differences were noted for levels of cholesterol, creatine, triglycerides, albumin, alanine aminotransferase and total protein. Both doses of all-trans-RA reduced albumin levels to approximately 90% of the control and total protein levels to approximately 93% of the control while substantially elevating triglyceride levels to approximately 66%-99% above the control. Additionally, triglyceride levels of the 15 mg kg(-1) 13-cis RA group were approximately 62% higher than the controls and total protein levels were approximately 5% less. Glucose levels were affected by sex and RA treatment in that males treated with 15 mg kg(-1) of 13-cis-RA or 10 mg kg(-1) all-trans-RA had lower (13%-19%) levels than the same-sex controls; however, females were not similarly affected. Neither 13-cis-RA nor all-trans-RA treatment had significant effects on the levels of blood urea nitrogen, aspartate amino transferase, leptin or adiponectin. On a mg kg(-1) basis, all-trans-RA was more potent than 13-cis-RA. These results replicate previous findings of RA-induced increased triglyceride levels. Additionally, several new findings indicate there may be sex-specific effects of RA treatment. Finally, neither treatment appeared to alter the typical diurnal cycles of these endpoints.

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“…Two of the a.m. glucose values were below normal for fed rats (44 and 51 mg/dl). 12 However, upon withdrawal of chow, blood glucose for these two animals increased over the next 5 h, and stabilized within a normal range. The highest blood glucose fell sharply within the first 30 min, and subsequently stabilized at approximately 70 mg/dl for the last 3 h of the fast.…”

Section: Bp-1 2xfurmentioning

confidence: 88%

Regulated hepatic insulin gene therapy of STZ-diabetic rats

2000

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Effective and safe insulin gene therapy will require regulation of transgenic insulin secretion. We have created a livertargeted insulin transgene by engineering glucose responsive elements into a hepatic promoter containing an inhibitory insulin response sequence. In this work, we demonstrate application of this transgene for the treatment of diabetes mellitus in vivo, by administering a recombinant adenovirus vector, Ad/(GlRE) 3 BP-1 2xfur, to rats made diabetic with streptozotocin. We verified hepatic expression of transgenic insulin by RT-PCR, and confirmed glucose responsive stimulation of transgenic insulin secretion in vivo by serum RIA. Following a portal system injection of either Ad/(GlRE) 3 BP-1 2xfur, or an empty adenoviral vector, animals made diabetic with either low (120 mg/kg), or high (290 mg/kg) dose streptozotocin (STZ) were monitored for changes in body weight, and blood glucose. Without subcutaneous insulin injections, blood glucose values of sham-

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Diurnal Variations in Blood Chemical Items in Sprague-Dawley Rats.

Cited by 23 publications

References 5 publications

Temporal changes in sensitivity of rats to cerebral ischemic insult

Temporal changes in sensitivity of rats to cerebral ischemic insult

Serum levels of albumin, triglycerides, total protein and glucose in rats are altered after oral treatment with low doses of 13-cis-retinoic acid or all-trans-retinoic acid

Regulated hepatic insulin gene therapy of STZ-diabetic rats

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