Diurnal variation of subjective mood in depressive states

Hall, Peter Richard; Spear, F. G.; Stirland, D

doi:10.1007/bf01573400

Cited by 28 publications

(17 citation statements)

References 16 publications

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“…Disturbances of sleep are common in depression, the most usual disturbance in typical depression being early morning awakening—insomnia in the terminal hours of sleep [Hawkins and Mendels, 1966]. Mood often varies systematically with time of day, generally worse in the morning [Hall et al, 1964]. A decrease in the latency to the onset of rapid eye movement (REM) sleep is among the most consistent biological findings in depression [Kupfer and Foster, 1972].…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphism at theCLOCK gene locus and major depression

et al. 2000

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Genetic analysis in both mouse and Drosophila has indicated that the product of the CLOCK gene is an essential component of a circadian rhythm timing system. A single nucleotide polymorphism (SNP), T3111C, in the 3' flanking region of the human CLOCK gene has been identified. Homozygotes or heterozygotes for the 3111C allele have been reported to have higher mean scores on a measure of evening preference for activity (vs. morning preference) than subjects homozygous for the 3111T allele. Since major depression is hypothesized to be closely linked to circadian rhythms, we explored whether this polymorphism might be related to susceptibility to major depression. We also ascertained allele frequency in an African-American control population, to begin to evaluate population variation at this locus. CLOCK T3111C allele frequencies were determined in 280 European American (EA) subjects, 143 with a history of major depression and 137 screened controls, and in 58 African American (AA) screened control subjects, using a polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) method. There was no significant difference between EA depressed and control subjects in allele frequency. There was a significant difference in allele frequency between EA and AA subjects, demonstrating a potential for population stratification. In none of these groups were significant deviations from Hardy-Weinberg equilibrium found. The present data do not support an association between CLOCK gene alleles at the T3111C locus and major depression.

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Section: Introductionmentioning

confidence: 99%

Genetic polymorphism at theCLOCK gene locus and major depression

et al. 2000

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“…A wide range of body functions such as body temperature, blood pressure, pulse rate, and hormones such as plasma cortisol levels, thyroid-stimulating hormone, and melatonin have been found disturbed in patients F o r P e e r R e v i e w with manic depression and depression compared with people without a mental disorders (Atkinson, Kripke and Wolf, 1975;Souêtre et al, 1989). Moreover, mood and other symptoms of the disorder have been previously reported to show diurnal variation in depression (Hall, Spear and Stirland, 1964). Disordered sleep/wake cycle is considered as another clue for physicians in patients with bipolar disorder (BD) and major depressive disorder (MDD) (Hall, Spear and Stirland, 1964).…”

Section: Mood Disordersmentioning

confidence: 99%

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

Kırlıoğlu

Balcıoğlu

2019

Preprint

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Several lines of evidence support a relationship between circadian disruption in the onset, course, and maintenance of mental disorders. Despite the study of circadian phenotypes promising a decent understanding of the pathophysiologic or etiologic mechanisms of psychiatric entities, several questions still need to be addressed. In this review, we aimed to synthesize the literature investigating chronobiologic theories and their associations with psychiatric entities. We first introduced molecular elements and mechanisms of the circadian system to promote a better understanding of the chronobiologic implications of mental disorders. Then, we comprehensively and systematically reviewed circadian system studies in mood disorders, schizophrenia, and anxiety disorders. Current research has demonstrated that circadian pathologies, including genetic and neurohumoral alterations, represent the neural substrates of the pathophysiology of many psychiatric disorders. However, much more work is needed to identify the causal relationship between circadian physiology abnormalities and mental disorders, and to develop sound pharmacologic interventions.

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“…Poznato je da pacijenti s bipolarnim poremećajima i velikim depresivnim epizodama pate od poremećaja sna i dnevnih varijacija raspoloženja (52). Postojanje sezonskih afektivnih poremećaja, kod kojih se epizode poremećaja raspoloženja javljaju sezonski, takođe ukazuje na vezu između na svetlost osetljivih patoloških promena raspoloženja i na svetlost osetljivih moždanih struktura cirkadijalnog sata (43,53,54).…”

Section: Kontrola Sistema Zadovoljstva I Motornog Odgovoraunclassified

10.5937/mckg48-5899 = Functional and anatomical aspects of the habenular complex of epithalamus

Marković¹,

Ognjanović²

2014

Medicinski casopis

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UVODepitalamus (epithalamus) predstavlja deo međumozga, smešten na dorzokaudalnom delu talamusa i po svojoj anatomskoj poziciji, ali i neuronskim vezama predstavlja "raskrsnicu" na kojoj se ukrštaju putevi limbičkog sistema, bazalnih ganglija, ali i mnogi drugi neuronski krugovi. Morfološki gledano sastoji se iz epifize (gl. pinealis), habenularnih jedara (nuclei habenulae), međuhabenularne spojnice (commisura habenularum) i striae medularis. Habenularni kompleks je parna struktura epitalamusa, sastavljena iz dva jedra -medijalnog (nc. habenularis medialis -MHb) i lateralnog (nc. habenularis lateralis -lHb). to je filogenetski stara moždana struktura sa kod većine kičmenjaka jasno uočljivom asimetrijom u veličini kompleksa desne i leve strane (1). Medijalno jedro habenule izgrađeno je od gusto pakovanih nervnih ćelija koje su na osnovu svojih citoarhitektonskih karakteristika svrstane u pet subnukleusa (2), dok se u okviru lateralnog habenularnog jedra opisuje 10 subnukleusa (3). anatomska lokalizacija i veze omogućavaju jedrima habenule ulogu u regulaciji mnoštva fizioloških mehanizama, ali i u patogenezi pojedinih bolesti, kao što su depresija, shizofrenija, Parkinsonova bolest, bolesti zavisnosti i dr. (4). u ovom radu prikazuju se nova saznanja o ulozi habenularnog kompleksa u normalnim, fiziološkim procesima, kao i patogenezi psihijatrijskih oboljenja. NEURONSKE VEZE HABENULARNOG KOMPLEKSAHabenularni kompleks predstavlja glavnu vezu između bazalnih ganglija i limbičkih delova telencefalona, s jedne

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Diurnal variation of subjective mood in depressive states

Cited by 28 publications

References 16 publications

Genetic polymorphism at theCLOCK gene locus and major depression

Genetic polymorphism at theCLOCK gene locus and major depression

Chronobiology Revisited in Psychiatric Disorders: From a Translational Perspective

10.5937/mckg48-5899 = Functional and anatomical aspects of the habenular complex of epithalamus

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