Diurnal variation of oral glucose tolerance in volunteers and laboratory animals

Ben-Dyke, R.

doi:10.1007/bf01212547

Cited by 26 publications

(11 citation statements)

References 10 publications

(10 reference statements)

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“…Possible effects prolonged storage were also investigated. 1 The same difference was also found when whole blood samples were stored in a higher concentration (3Yo) of perchloric acid.…”

Section: Appendixmentioning

confidence: 67%

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Diurnal and seasonal variation in oral glucose tolerance: Studies in the antarctic

1975

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Oral glucose tolerance tests were performed in 12 young men in the Antarctic. Tests were done in the morning and afternoon at three monthly intervals (March, June, September, December). The characteristic diurnal variation in glucose tolerance persisted throughout the year, but was greater in the warmer months (March and December). There were significant seasonal differences in glucose tolerance; blood glucose values were lowest, both morning and afternoon, in December (midsummer). In one pair of tests performed during a reversal of normal sleep/activity pattern, the direction of the normal diurnal variation of glucose tolerance was also reversed.

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“…Possible effects prolonged storage were also investigated. 1 The same difference was also found when whole blood samples were stored in a higher concentration (3Yo) of perchloric acid.…”

Section: Appendixmentioning

confidence: 67%

“…Diurnal variation in oral glucose tolerance has been described by several authors [23,3,12,13,1] and is now a well recognised phenomenon. The magnitude and the nature of the variation has been investigated in relation to obesity, age, degree of glucose intolerance [13,20,26], and the insulin response [11,4,26].…”

mentioning

confidence: 97%

Diurnal and seasonal variation in oral glucose tolerance: Studies in the antarctic

1975

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“…However, insulin sensitivity is also said to be diminished in the evening (75). The lower outflow rate constant is consistent with the lessening of glucose tolerance in the afternoon as compared to the morning (68,(76)(77)(78).…”

Section: Possible Reasons For the Diversity Of Findings In The Pastmentioning

confidence: 72%

Glucose Turnover and Disposal in Maturity-Onset Diabetes

Bowen¹,

Moorhouse²

1973

J. Clin. Invest.

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A B S T R A C T The glucose turnover rate in maturityonset diabetes in man has been variously reported as increased, normal, and decreased. The present experiments suggest that these discrepancies may have been due to methodology, and to nonrecognition of a circadian cycle in the glucose turnover rate that is present in health, and marked in diabetes.During the early morning hours the glucose turnover rate in maturity-onset diabetes is increased in proportion to the fasting blood glucose level. It may reach three to four times the rate found in health. During the evening hours the increments are about one-half as great.The glucose outflow rate constant, k, lower in diabetes than in health, is also lower in both groups in the evening than in the morning.An analysis of the relative contributions of glucose overproduction and underutilization to the development of hyperglycemia in maturity-onset diabetes indicates that overproduction is the greater factor. The relative role of underutilization appears to increase as the fasting blood glucose level increases.The circulating glucose oxidation rate in maturityonset diabetes is only slightly lower than in health, but the fraction oxidized is markedly lower, and only a small fraction is excreted.The principal conclusion is that in maturity-onset diabetes there is a hypertrophied flux of endogenous glucose, most of which is neither oxidized nor excreted. The precursors and the qualitative and quantitative metabolic fates of this excess glucose are unknown.

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“…However, since the daily dose of chlorpropamide was given at 7.30 a.m. and may have influenced the responses to the first meal of the day, consumed 30 min later, these variations may be drug-in duced rather than true circadian rhythms. Thus, we can neither support nor deny the contention that glucose tolerance tests must be done at the same time of the day, if they are to be compared [8,49]. We were unable to detect the diurnal variations of serum FFA that have been observed by other in vestigators [5], and we would like to believe that this may represent addi tional evidence that our subjects were not unduly stressed and, hence, did not secrete variable amounts of catecholamines, ACTH and other hormones that would have stimulated lipolysis.…”

Section: Discussionmentioning

confidence: 99%

Diurnal Variations of Serum Insulin, Total Glucagon, Cortisol, Glucose and Free Fatty Acids in Normal and Diabetic Subjects before and after Treatment with Chlorpropamide

Loreti¹,

Sugase²,

Foà³

1974

Horm Res

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Serum levels of insulin (IRI), total glucagons (GLI), cortisol, glucose and free fatty acids were measured in 14 normal subjects and in 6 diabetic patients. All of them were hospitalized, but not con- , fined to bed and were given 3 daily meals of identical carbohydrate, fat and protein content. Blood samples were collected through an indwelling venous catheter at hourly intervals for 72 h. In addition, three 15-min samples were collected after each meal. The study was repeated about 1 month later, during the last 3 days of a period of chlorpropamide treatment. The results confirm the existence of a diurnal cycle in serum cortisol in normal and diabetic subjects. Diurnal variations in the postprandial glucose response of normal subjects and in the postprandial IRI response of diabetic patients were observed, but they may have been drug-induced. Chlorpropamide treatment had no significant effects in normal subjects, but was followed by a decrease in the concentration of serum GLI and by an increase in the fasting levels of IRI and in the IRI response to meals in diabetic patients. These changes may explain the restraining effect that the drug had on postprandial hyperglycemia. The results of our experiments suggest that the therapeutic effect of chlorpropamide in adult onset diabetic patients may be due to a combination of an increased release of insulin and a decreased release of total gucagon in response to the ingestion of food. The difference in the response of normal and diabetic subjects to prolonged chlorpropamide treatment remains unexplained, but may account for some of the conflicting reports on the effects of sulfonylurea derivatives on insular function.

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Diurnal variation of oral glucose tolerance in volunteers and laboratory animals

Cited by 26 publications

References 10 publications

Diurnal and seasonal variation in oral glucose tolerance: Studies in the antarctic

Diurnal and seasonal variation in oral glucose tolerance: Studies in the antarctic

Glucose Turnover and Disposal in Maturity-Onset Diabetes

Diurnal Variations of Serum Insulin, Total Glucagon, Cortisol, Glucose and Free Fatty Acids in Normal and Diabetic Subjects before and after Treatment with Chlorpropamide

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