Diurnal Variation of Intraocular Pressure in the Normal Eye

The effect of caffeine on intraocular pressure: a systematic review and meta-analysis

“…Two [5,7] of the six studies did not report the follow-up time point. If measuring time points had varied among follow-ups, the IOP measured might be confounded by its diurnal variation [42,43]. Three types of tonometries with different reliability were used in the included studies.…”

Normal Intraocular Pressure in Man

“…that is to say about 20% reduc tion over a lifetime [47]. Moreover, intraoc ular pressure fluctuates diurnally by 3-6 mm Hg [48]. Therefore, the normal intraocular pressure should be reported as the average of several measurements at different times of day in a homogenous, normal group, that is one consisting of young, healthy adults.…”

A scleral buckle pressure gauge for continuous monitoring of intraocular pressure

“…In the normal eye, there is a small diurnal intraocular pressure variation, averaging 3 to 4 ram Hg, but in the glaucomatous eye this diurnal variation may be much greater (15-20 mm Hg) and treatment can further exaggerate these variations (5). Deter~ mining the peak of the diurnal IOP variations is important in the diagnosis and management of glaucoma (6,9).…”

“…Its movement (and concomitant deformation of the sclera) was detected by a resonant coil comlgination. The entire pressure sensor was held against the sclera by a silicone rubber band (5).…”