Diurnal Variation of Haemostatic Response to Exercise in Young Sedentary Males

Abstract

The aim of this study was to evaluate diurnal variations in the haemostatic response to submaximal exercise performed by young, sedentary men. Fifteen healthy young sedentary males aged 25.6 ± 1.34 (mean ± SD) years performed two exercise sessions, morning and evening, at 70% of maximal oxygen consumption (V.O2max) on a cycle ergometer for 30 min. Platelet count (PC), activated partial thromboplastin time (aPTT), prothrombin time (PT), fibrinogen, tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1) activity were measured as dependent variables. Exercise produced significant increases in PC and fibrinogen for both sessions (P ≤ 0.05), which returned to the resting values after recovery only in the evening session. APTT and PT shortened immediately after exercise, which remained after recovery for both sessions (P ≤ 0.01). Exercise presented significant increases in tPA activity (P ≤ 0.001), which returned to the baseline after recovery in both exercises. PAI-1 activity was significantly higher during the morning than evening (P ≤ 0.05), but no longer demonstrated exercise-related changes. It was found that exercise caused activation of both coagulation and fibrinolysis processes, partly related to the time of the day when the exercise was performed.

Acquired and Genetic Thrombotic Risk Factors in the Athlete

“…14 The findings of Szymanski and Pate 96 mirrored the diurnal rhythms previously reported for tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1), with both markers significantly increased post exercise (p < 0.05), with greater concentrations observed immediately following evening exercise (p < 0.001). In contrast to Szymanski and Pate, 97 Siahkouhian and associates 13 failed to demonstrate the time of day response in markers of coagulation and fibrinolysis following both morning and evening exercise, despite significant increases (p < 0.05) in post exercise plasma concentrations of hemostasis. When investigating platelet responses to exercise at two different times of the day, mean platelet volume and platelet aggregation were demonstrated to display significant time of the day differences, with greater increases observed following morning exercise 16 (►Table 2).…”

“…Of increasing difficulty is the failure to report the time of day in which exercise is completed when investigating coagulation and fibrinolytic responses. To investigate diurnal rhythms in response to exercise completed at different times of the day, three separate investigations 13,16,96 have employed similar exercise protocols with varying exercise intensities over two different time points (►Table 2), while a single investigation has examined the influence of a shorter-duration, high-intensity bout of exercise over five individual time points. 14 The findings of Szymanski and Pate 96 mirrored the diurnal rhythms previously reported for tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1), with both markers significantly increased post exercise (p < 0.05), with greater concentrations observed immediately following evening exercise (p < 0.001).…”

“…numerous factors, including the study population assessed with regard to training status; age and gender [11][12][13] ; the exercise type, intensity, and duration 6,9,14 ; and the time of the day the exercise is performed. [15][16][17] Although exerciseinduced hemostatic activation may not be detrimental to most individuals, approximately 1 in 1,000 athletes 12,18 may experience a post-exercise-related thromboembolic incident, similar to that of the general population, albeit in the absence of exercise.…”

Effects of Anaerobic Exercise in the Morning and Evening Sessions on some Coagulation Factors in Non-Athletes Female Students of Islamic Azad University of Sanandaj

“…Siahkouhian (2012) reported a significant difference between the morning and evening (13). PT is extrinsic pathway of coagulation initiation and shorting of it is dependent on the concentration of prothrombin.…”

“…and often hematological status lower than normal is observed in athletes who are involved in intense exercise [16]. All these changes showed significant difference in morning and evening (13). According to Different results of this study and other similar studies, in conjunction with the effect of anaerobic exercise on blood coagulation factors and fibrinolysis the athletes and non-athletes persons in the present study efforts examined the affect of this exercises on blood coagulation system and fibrinolysis in the training of athletes and non-athletes, and recovery time.…”