Diurnal variation of flow-mediated dilatation in healthy humans

Kim, Yong Cheol; Yun, Kyeong Ho; Woo, Sun Ho; Jeong, Young Hoon; Lim, Jae Hong; Hwang, Kyo Bum; Jeong, Jin Woo; Lee, Mi Rim; Lee, Jeongmi; Rhee, Sang Hoon; Kim, Nam-Ho; Oh, Seok; Jeong, Jaehoon

doi:10.1186/s40885-015-0019-4

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…We did not have a control group in this study, although all comparisons are made within subjects. Time of day may influence FMD (Jones et al 2009 ; Al Mheid et al 2014 ), although findings are equivocal (Kim et al 2015 ). Consequently, all efforts were made to retest all subjects at the same time of the day for all repeat measurements.…”

Section: Discussionmentioning

confidence: 99%

Do acute effects of exercise on vascular function predict adaptation to training?

et al. 2017

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PurposeNo previous study has explored the importance of exercise-induced changes in vascular function to prolonged adaptations. Therefore, the purpose was to explore the within-subject relationship between the acute post-exercise change in brachial artery endothelial function (flow-mediated dilation, FMD) and the change in resting FMD after a 2-week exercise training in healthy volunteers.MethodsTwenty one healthy, young men (24 ± 5 years) underwent assessment of brachial artery FMD using high-resolution ultrasound before and after 30-min of moderate-intensity cycle exercise (80% maximal heart rate). Subsequently, subjects performed five 30-min cycle exercise bouts at 80% maximal heart rate across a 2-week period, followed by repeat assessment of resting brachial FMD post-training. ResultsCorrecting for changes in diameter and shear, FMD did not change after the initial exercise bout (P = 0.26). However, a significant correlation was found between post-exercise changes in FMD and adaptation in resting FMD after training (r = 0.634, P = 0.002), where an acute decrease in post-exercise FMD resulted in a decrease in baseline FMD after 2 weeks and vice versa. We also found a positive correlation between antegrade shear rate during exercise and change in FMD% after acute exercise and after exercise training (r = 0.529 and 0.475, both P < 0.05).ConclusionOur findings suggest that acute post-exercise changes in vascular function are related to changes in resting FMD after a 2-week endurance exercise training period in healthy men, an effect that may be related to exercise-induced increases in antegrade shear rate. This provides further insight into the relevance of acute changes in shear and FMD for subsequent adaptation.

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Section: Discussionmentioning

confidence: 99%

Do acute effects of exercise on vascular function predict adaptation to training?

et al. 2017

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“…Although contraceptive use was consistent throughout the testing period, it could impact vascular function (Friedman et al, 2011). Despite the diurnal variation of vascular function remaining contentious (Bau et al, 2008; Jarvisalo et al, 2006; Kim et al, 2015), subjects were encouraged and primarily attended similar testing times across visits, although this was not always possible, and some visit start times may have varied ~4 h throughout the day. Although vascular function alterations within the menstrual cycle may be minimal (Williams et al, 2020), female participants reported to the lab at 1‐month intervals which minimized menstrual cycle fluctuations in vascular function within participants, while the cycle phase between participants was not controlled for.…”

Section: Discussionmentioning

confidence: 99%

Tracking peripheral vascular function for six months in young adults following SARS‐CoV‐2 infection

Province

Szeghy

Stute

et al. 2022

Physiological Reports

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SARS-CoV-2 infection is known to instigate a range of physiologic perturbations, including vascular dysfunction. However, little work has concluded how long these effects may last, especially among young adults with mild symptoms. To determine potential recovery from acute vascular dysfunction in young adults (8 M/8F, 21 ± 1 yr, 23.5 ± 3.1 kg⋅m −2 ), we longitudinally tracked brachial artery flow-mediated dilation (FMD) and reactive hyperemia (RH) in the arm and hyperemic response to passive limb movement (PLM) in the leg, with Doppler ultrasound, as well as circulating biomarkers of inflammation (interleukin-6, Creactive protein), oxidative stress (thiobarbituric acid reactive substances, protein carbonyl), antioxidant capacity (superoxide dismutase), and nitric oxide bioavailability (nitrite) monthly for a 6-month period post-SARS-CoV-2 infection. FMD, as a marker of macrovascular function, improved from month 1 (3.06 ± 1.39%) to month 6 (6.60 ± 2.07%; p < 0.001). FMD/Shear improved from month one (0.10 ± 0.06 AU) to month six (0.18 ± 0.70 AU; p = 0.002). RH in the arm and PLM in the leg, as markers of microvascular function, did not change during the 6 months (p > 0.05). Circulating markers of inflammation, oxidative stress, antioxidant capacity, and nitric oxide bioavailability did not change during the 6 months (p > 0.05). Together, these results suggest some improvements in macrovascular, but not microvascular function, over 6 months following SARS-CoV-2 infection. The data also suggest persistent ramifications for cardiovascular health among those recovering from mild illness and among young, otherwise healthy adults with SARS-CoV-2.

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“…However, days 1-5 and the placebo pill phase correspond to the lowest plasma estradiol levels in women who have natural menstrual cycles and those taking oral contraceptives, respectively (7,42,54). The time of day when the vascular assessments were conducted varied between participants (i.e., beginning from 8:30 AM to 4 PM), which may (23,32,36,49) or may not (3,24) influence endothelial function. Importantly, men and women were tested at a similar time of day (men: 12:09 PM Ϯ 2.44 h; women: 11:49 AM Ϯ 3.75 h; P ϭ 0.76), and a similar proportion of each sex was tested in the morning (men: n ϭ 5; women: n ϭ 6) and afternoon (men: n ϭ 5; women: n ϭ 4).…”

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confidence: 99%

Sex does not influence impairments in popliteal endothelial-dependent vasodilator or vasoconstrictor responses following prolonged sitting

O’Brien

Johns

Williams

et al. 2019

Journal of Applied Physiology

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An acute bout of prolonged sitting (PS) impairs the popliteal artery flow-mediated dilation (FMD) response. Despite equivocal reductions in mean shear rate, young women demonstrate an attenuated decline in popliteal FMD versus young men. However, it is uncertain whether popliteal endothelial-dependent vasoconstrictor responses [low-flow-mediated constriction (L-FMC)] are similarly affected by PS and/or whether sex differences exist. We tested the hypothesis that women would have attenuated reductions in both popliteal FMD and L-FMC responses following an acute bout of PS. Popliteal FMD and L-FMC responses were assessed via duplex ultrasonography before and after a 3-h bout of PS. These responses were then compared between 10 men (24 ± 2 yr) and 10 women (23 ± 2 yr) with similar ( P > 0.13) levels of objectively measured habitual physical activity (via PiezoRx) and sedentary time (via activPAL). At baseline, men and women exhibited similar ( P > 0.46) popliteal FMD (4.8 ± 1.2 vs. 4.5 ± 0.6%) and L-FMC (–1.7 ± 1.0 vs. –1.9 ± 0.9%) responses. Both sexes experienced identical (group: P > 0.76; time: P < 0.001) PS-induced impairments in popliteal FMD (–2.8 ± 1.4 vs. –2.6 ± 0.9%) and L-FMC (1.3 ± 0.7% vs. 1.4 ± 0.7%). In young adults, sex did not influence the negative PS-induced FMD, L-FMC, or microvascular responses in the lower limb. As such, our findings suggest that young men and women are similarly susceptible to the acute negative vascular effects of PS. Future studies should extend these findings to older, less physically active adults and/or patients with vascular disease. NEW & NOTEWORTHY We compared changes in popliteal artery endothelial function to a single 3-h bout of sitting between young men and women. Both groups exhibited similar endothelial-dependent vasodilation (i.e., flow-mediated dilation) and endothelial-dependent vasoconstrictor responses (i.e., low-flow-mediated constriction) at baseline and equivocal impairments in these measures of endothelial function following prolonged sitting. These findings demonstrate that acute impairments in conduit artery endothelial health associated with uninterrupted sitting are not influenced by sex in young, healthy adults.

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Diurnal variation of flow-mediated dilatation in healthy humans

Cited by 6 publications

References 26 publications

Do acute effects of exercise on vascular function predict adaptation to training?

Do acute effects of exercise on vascular function predict adaptation to training?

Tracking peripheral vascular function for six months in young adults following SARS‐CoV‐2 infection

Sex does not influence impairments in popliteal endothelial-dependent vasodilator or vasoconstrictor responses following prolonged sitting

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