Diurnal Variation of 17-Hydroxycorticosteroids, Sodium, Potassium, Magnesium and Creatinine in Normal Subjects and in Cases of Treated Adrenal Insufficiency and Cushing's Syndrome*†

Doe, Richard P.; Vennes, Jack A.; Flink, Edmund B.; Engst, Ruth; Johnson, Phyllis E.; Lewis, Mary D.

doi:10.1210/jcem-20-2-253

Cited by 139 publications

(39 citation statements)

References 21 publications

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“…40,43,[47][48][49]52 Diurnal variations in excretion of sodium, chloride, potassium, and water have been observed in many studies. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Creatinine excretion has generally been reported to be fairly constant over 24 h, 2,7,11,26,28 and on average this was the case for the men in this study. Water and electrolyte excretion in healthy individuals generally reaches a maximum sometime around midday and a minimum toward the end of sleep.…”

Section: Discussionmentioning

confidence: 94%

“…15 Reversal of this diurnal cycle in excretion of sodium, chloride, and water has been reported for several diseases including hypertension. 10,[17][18][19][20][21][22][23][24][25][26][27] In a study of 12 hypertensive patients, Vagnucci and Wesson 17 found that maximal chloride excretion occurred during daytime in seven persons and during sleep in five. There was no reversal in the diurnal pattern of potassium excretion.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] A reversal of the usual diurnal cycle of sodium, chloride, and water excretion (ie, higher excretion at night) has been reported for persons with a number of diseases. 10,[17][18][19][20][21][22] Investigators have also reported a reversal or flattening of the usual cycle of sodium and chloride excretion in hypertensives. 17,[23][24][25][26][27] In a previous report, Dyer et al 26 found on average no diurnal variation in excretion of sodium and water in a group of hypertensive men and women, with more than half showing a higher rate of sodium and water excretion at night than during the day.…”

Section: Introductionmentioning

confidence: 99%

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Blood pressure and diurnal variation in sodium, potassium, and water excretion

et al. 1998

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The objective of this study was to examine associations of blood pressure (BP) with ratios of overnight to 24-h urinary excretion of sodium, potassium, and water. Each of 125 men 27-64 years of age, not taking diuretics, had BP measured during the day on a Monday. Beginning Monday evening, each participant provided three carefully timed 24-h urine collections, divided into daytime and overnight (bedtime to awakening) specimens. Proportion of total 24-h excretion of sodium, potassium, and water in the overnight specimen, standardised for creatinine excretion, was determined for each 24-h period. Associations of systolic and diastolic BP (SBP/DBP) with these proportions were examined with control for age, body mass index, alcohol intake, and heart rate. Mean BP was 116/71 mm Hg; 15 men were on non-diuretic anti-hypertensive therapy. Mean 24-h urinary excretion was 168 mmol for sodium, 68 mmol for potassium, and 16 mmol for creatinine. Mean overnight

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Blood pressure and diurnal variation in sodium, potassium, and water excretion

et al. 1998

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“…The significance of this phase shift is obscure. Reversal of the diurnal cycle of renal sodium or chloride excretion has been reported in cirrhosis of the liver (22,23), in congestive heart failure (23)(24)(25), in hypertension (26), glomerulonephritis (23,26), nephrosis (27), Cushing's disease (28), primary hyperaldosteronism (29), obesity or head injury (30), and after inversion of the sleep-activity routine (31,32). GFR has been measured in two of these conditions.…”

Section: Electrolyte Excretionmentioning

confidence: 99%

Diurnal Cycle of Renal Hemodynamics and Excretion of Chloride and Potassium in Hypertensive Subjects *

Vagnucci¹,

Wesson²

1964

J. Clin. Invest.

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“…1 " 16 A reversal of the usual diurnal cycle of sodium, chloride, and water excretion (i.e., higher excretion at night) has been reported for persons with such diseases as cirrhosis of the liver, congestive heart failure, nephrosis, glomerulonephritis, Cushing's disease, and primary hyperaldosteronism. 10 ' "~u Some investigators have also reported a reversal of the usual cycle of sodium and chloride excretion in hypertensive persons.…”

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confidence: 99%

Do hypertensive patients have a different diurnal pattern of electrolyte excretion?

et al. 1987

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SUMMARY Studies generally indicate that excretion of sodium, potassium, and water is greater during the day than during the night. To determine whether hypertensive patients exhibit this same pattern of excretion, diurnal variations in excretion of sodium, potassium, creatinine, and water were examined in 107 hypertensive men and women from a clinical trial on control of hypertension by nonpharmacological means -the Hypertension Control Program. Each participant provided two carefully timed 24-hour urine collections divided into daytime and overnight specimens. The median ratios of 24-hour to 8-hour overnight excretion were 2.84,3.95,2.99, and 2.77 for sodium, potassium, creatinine, and water, respectively. Thus, more than half of this hypertensive group exhibited a greater rate of sodium and water excretion during sleep than during daytime hours, a reversal of the usual pattern. When the group was subdivided based on age, sex, race, trial randomization group, use of diuretics, and hypertension severity, women had significantly lower ratios of 24-hour to overnight excretion for sodium and water than men and blacks had significantly lower 24-hour to overnight ratios for water and potassium than whites. When the 24-hour to overnight ratios for these hypertensive patients were compared with those for a group of 30 men and women with high-normal blood pressure, those with high-normal blood pressure had significantly larger ratios for sodium and water excretion than the hypertensive group. The results of this study suggest that hypertensive patients may have a different diurnal pattern of sodium and water excretion than normotensive subjects and that further research is needed to clarify this issue. (Hypertension 10: 417-424, 1987) KEY WORDS • hypertension • electrolytes • diurnal patterns D IURNAL variations in urinary excretion of sodium, chloride, potassium, and water have long been recognized, with excretion of water and electrolytes generally reaching a maximum some-

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Diurnal Variation of 17-Hydroxycorticosteroids, Sodium, Potassium, Magnesium and Creatinine in Normal Subjects and in Cases of Treated Adrenal Insufficiency and Cushing's Syndrome*†

Cited by 139 publications

References 21 publications

Blood pressure and diurnal variation in sodium, potassium, and water excretion

Blood pressure and diurnal variation in sodium, potassium, and water excretion

Diurnal Cycle of Renal Hemodynamics and Excretion of Chloride and Potassium in Hypertensive Subjects *

Do hypertensive patients have a different diurnal pattern of electrolyte excretion?

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