Diurnal changes in activities of AspAT, A1AT, FDPA, MDH, ICDH and LDH in liver of mice fed high and low protein diet

Daily Rhythm of Lactate Dehydrogenase in Rat (Rattus norvegicus) Carrying a Per1-luciferase Transgene: Assessment on Serum and Liver

“…Particularly, LDH 1 is in myocardium, in red blood cells, in kidney (at cortical level) and in skeletal muscles; LDH 2 is in myocardium, in red blood cells, in kidney (at cortical level), in pancreas, in lung and in skeletal muscle LDH 3 is in lung, placenta, in skeletal muscle and in pancreas; LDH 4 in kidney (at medulla level), in skeletal muscles, in lung and in placenta; LDH 5 is in liver, kidney (at medulla level), skeletal muscle and in pancreas (Wolf and Williams, 1973). In previous studies (North et al, 1981;Zaleska-Freljian and Priebe, 1991) LDH showed rhythmicity with acrophases prior to the dark onset that seemed to be influenced by feeding (Sitren and Stevenson, 1978). In our study, liver LDH showed a rhythmic pattern coincident with values reported in literature (Figures 2A and B).…”

Daily oscillations in liver function: diurnal vs circadian rhythmicity

“…Other enzymes involved in amino acid regulation show diurnal rhythmicity as well. Alanine transaminase activity has been shown to peak in the morning (31) or night (32). North et al (33) reported that the peak occurs in male mice near dark onset in both standard and reverse LD conditions.…”

“…Some studies have consistently shown an early evening peak in lactate dehydrogenase (LDH) activity that anticipates dark onset (31, 33) in either LD or RF conditions (43). When feeding is controlled, the peak anticipates availability of the daily meal (44).…”