Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions

Smolensky, Michael H.; Portaluppi, Francesco; Manfredini, Roberto; Hermida, Ramón C.; Tiseo, Ruana; Sackett-Lundeen, L; Haus, Erhard

doi:10.1016/j.smrv.2014.06.005

Cited by 100 publications

(83 citation statements)

References 130 publications

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“…Informa Healthcare USA, Inc. Chronobiol Int Downloaded from informahealthcare.com by Michigan University on 12/22/14 the morning. In addition, syncope in the elderly may sometimes be precipitated by urination and bowel movement; thus, time patterns of such (Smolensky et al, 2014b) during the 24 h may play a significant role in the observed day-night patterns of falls in the various publications reviewed herein. The symptom intensity of many common morbid conditions of the elderly, such as rheumatoid arthritis, osteoarthritis, congestive heart failure, transient ischemia attack, gastroesophageal reflux, peptic ulcer, certain chest diseases, and various pain syndromes, among many others, undergoes marked circadian rhythmicity (Smolensky et al, 2014a, b), and directly or indirectly they may contribute to the reported time-of-day major and minor peaks in fall frequency when data of hospitals or nursing homes or other longterm care facilities were pooled by clock hour.…”

Section: Limitationsmentioning

confidence: 97%

“…None of the review papers examined temporal differences in the relative risk of falls in elderly institutionalized cohorts, for example, by examining per clock hour the number of falls detected relative to the number of persons who were ambulatory or otherwise at risk to falls, and in the case of falls in specific places, such as the bathroom, for example, by examining per clock hour the number of falls by elderly in bathrooms relative to the number elderly exposed to bathroom use. Expectations are that bathroom use to urinate by a large proportion of both elderly men and women is highly common at night and for defecation most common in the morning (Smolensky et al, 2014b). Relative risk is an important concept in (chrono) epidemiology, even though it is often ignored, as illustrated by the recent study by Riedel et al (2011).…”

Section: Limitationsmentioning

confidence: 99%

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24-hour pattern of falls in hospitalized and long-term care institutionalized elderly persons: A systematic review of the published literature

López‐Soto

Manfredini

Smolensky

et al. 2014

Chronobiology International

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Falls are common among the elderly > 65 years of age and can result in both serious trauma and costly medical care. The epidemiology of falls in the elderly typically focuses on identifying contributory exogenous environmental and endogenous age-related physical, cognitive and other health status factors; however, one potentially important variable seldom considered is time of fall. We sought to determine if falls in hospitalized/institutionalized elderly persons exhibit 24 h and other temporal patterns, since knowledge of such could be useful in their prevention. We conducted a systematic review of the published literature to critically appraise and synthesize the methods and findings of previous reports addressing clock-time, day-of-week and month-of-year fall patterns of institutionalized elderly cohorts. Medline, SCOPUS, Ovid SP and Web of Knowledge were systematic assessed, entering search terms of "accidental fall", "circadian rhythm", "biological clocks", "circadian clocks", "activity cycles", "periodicity", and with databases accepting an age limiter, "age of 65(+) years". Methodological quality was assessed by STROBE and CONSORT checklists, respectively, in observational and clinical studies. Publications were reviewed if meeting inclusion criteria of: (i) being an empirical study, (ii) adopting circadian and/or other period rhythmicity as a fall risk, and (iii) focusing on hospitalized/institutionalized falls in those ≥ 65 years of age; plus exclusion criteria of: (i) cohort < 65 years of age and (ii) reports as dissertations or editorials. The search retrieved 170 publications; however, only nine met all inclusion/exclusion criteria. Typically, past studies disregarded the temporal aspects of fall incidents; the few that did varied in quality, institutional setting, and patient type, i.e. medical diagnoses. Overall, findings suggest a single or double-peak 24 h pattern of fall incidence, with time of greatest incidence seemingly associated with circadian rhythm-dependent differences in the symptom intensity of dominating medical diagnoses (e.g. heart failure versus Alzheimer syndrome) among sample cohorts plus location (e.g. bathroom versus hallway) of occurrence. Future research is urgently required to define temporal patterns in falls and their etiology, e.g. relative to circadian and other rhythms in both the manifestation and intensity of medical conditions and adverse effects of medications according to scheduling, plus staff personnel number and work schedules as it affects patient oversight, and cyclic environmental conditions (e.g. light intensity exposure) to best design preventive measures.

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Section: Limitationsmentioning

confidence: 97%

Section: Limitationsmentioning

confidence: 99%

24-hour pattern of falls in hospitalized and long-term care institutionalized elderly persons: A systematic review of the published literature

López‐Soto

Manfredini

Smolensky

et al. 2014

Chronobiology International

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“…Age, mechanical injuries, and chronic inflammation are known risk factors, disrupting the function and viability of chondrocytes and leading to an imbalance between the catabolic and anabolic pathways (1-3). As a weight-bearing tissue, articular cartilage is exposed to the daily loading and unloading cycles associated with the circadian (24-hour) rhythms of rest and activity, and sufferers of OA experience time-of-day dependence in their symptoms (4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

Dudek¹,

Gossan²,

Yang³

et al. 2015

Journal of Clinical Investigation

164

202

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“…38 Hallazgos recientes muestran que el ritmo circadiano es un importante componente regulador de la reacción alérgica local y sistémica. 39 • Alergias anteriores o actuales, infecciones, enfermedades internas u otras causas posibles.…”

Section: 37unclassified

¿Es posible simplificar el abordaje diagnóstico de urticaria crónica? Una lista de verificación de información clínica

Chérrez-Ojeda

Robles‐Velasco

Bedoya-Riofrio

et al. 2017

RAM

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Background: Existing clinical guidelines do not offer an efficient alternative for the collection of data on relevant clinical traits during history and physical of the patient with chronic urticaria. Objective: Our aim was to provide a clinical data checklist together with its guide to allow for thorough information to be obtained and for a physical exam that identifies the main features and triggering factors of the disease to be carried out. Methods: A search was conducted for relevant literature on chronic urticaria in Medline, the Cochrane library and PubMed. Results: We developed an easy-to-use clinical data checklist with its corresponding clinical guide, comprised by 42 items based on two components: essential clues for history taking and chronic urticaria diagnosis (typical symptoms according to subgroups, etiology and laboratory results). Some components are the time of disease onset, wheals' duration, shape, size, color and distribution, associated angioedema, atopy, triggering factors and others. Conclusions: The clinical data checklist and its guide constitute a tool to focus, guide and save time in medical consultation, with the main purpose to aid physicians in providing better diagnosis and management of the disease.

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Diurnal and twenty-four hour patterning of human diseases: acute and chronic common and uncommon medical conditions

Cited by 100 publications

References 130 publications

24-hour pattern of falls in hospitalized and long-term care institutionalized elderly persons: A systematic review of the published literature

24-hour pattern of falls in hospitalized and long-term care institutionalized elderly persons: A systematic review of the published literature

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

¿Es posible simplificar el abordaje diagnóstico de urticaria crónica? Una lista de verificación de información clínica

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