Abstract:The oral microbiome is linked to oral and systemic health, but its fluctuation under frequent daily activities remains elusive. Here, we sampled saliva at 10- to 60-min intervals to track the high-resolution microbiome dynamics during the course of human activities. This dense time series data showed that eating activity markedly perturbed the salivary microbiota, with tongue-specific Campylobacter concisus and Oribacterium sinus and dental plaque-specific Lautropia mirabilis, Rothia aeria, and Neisseria orali… Show more
“…Hu et al sampled saliva at 10 to 60 min intervals to track the high-resolution microbiome dynamics during the course of human eating activities for 5 days. 51 Indeed, it is uncertain whether the abundance of streptococcal species analyzed only 5 h after SSN-AS vicR treatment has biological significance, and further investigations are needed. Regarding the high degree of conservation of vicR genes, there is a 71.5% similarity of vicR genes between S. mutans and S. gordonii , as well as a 72.6% similarity of vicR genes between S. mutans and S. sanguinis .…”
We developed SSN nanovector for ASvicR delivery using natural starch spermine to protect ASvicR from nuclease degradation and achieve high transformation efficiency, inhibit EPS and cariogenicity of S. mutans, maintain oral flora homeostasis.
“…Hu et al sampled saliva at 10 to 60 min intervals to track the high-resolution microbiome dynamics during the course of human eating activities for 5 days. 51 Indeed, it is uncertain whether the abundance of streptococcal species analyzed only 5 h after SSN-AS vicR treatment has biological significance, and further investigations are needed. Regarding the high degree of conservation of vicR genes, there is a 71.5% similarity of vicR genes between S. mutans and S. gordonii , as well as a 72.6% similarity of vicR genes between S. mutans and S. sanguinis .…”
We developed SSN nanovector for ASvicR delivery using natural starch spermine to protect ASvicR from nuclease degradation and achieve high transformation efficiency, inhibit EPS and cariogenicity of S. mutans, maintain oral flora homeostasis.
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