Diuretika

The Pathogenesis and Prevention of Radiocontrast Medium-Induced Renal Dysfunction

“…Adenosine has also been shown to be involved in renal autoregulation of tissue perfusion (Hall et al 1985;Osswald et al 1978). Inhibition of adenosine activity via an adenosine (A1) receptor antagonist or its production via theophylline attenuates tubuloglomerular feedback and autoregulation mechanisms (Arend et al 1987;Osswald et al 1978Osswald et al , 1995Tagawa and Vander 1970).…”

“…Adenosine, a well-known vasodilator in the peripheral circulation, acts as a vasoconstrictor in the renal cortex (Hall et al 1985;Osswald et al 1978Osswald et al , 1995Pflueger et al 2000;Spielman and Thompson 1995;Tagawa and Vander 1970;Yao et al 2001). Furthermore, hypertonic ultrafiltrates, including hyperosmolar RCM, have been shown to induce the release of adenosine from the macula densa cells of the distal tubule (Osswald et al 1978).…”

“…Numerous studies have evaluated the modulatory role of prostaglandins of the E series (PGEs) on renal hemodynamics following RCM administration (Lear et al 1990;Margulies et al 1990;Osswald et al 1995). PGE2 administration has been shown to prevent hypoxic injury to the renal medulla by inhibiting oxygen consumption (Lear et al 1990).…”