Diuretics and β-Blockers Do Not Have Adverse Effects at 1 Year on Plasma Lipid and Lipoprotein Profiles in Men With Hypertension

Abstract

None of these 6 antihypertensive drugs has any long-term adverse effects on PLPPs and, therefore, may be safely prescribed. Previously reported short-term adverse effects from using hydrochlorothiazide are limited to nonresponders.

The association between antihypertensive drug therapies and plasma lipid levels in the general population

“…Whether these effects were only temporary is uncertain. 2,4 The fact that the differences in plasma lipid levels between subjects who used beta-blockers compared to untreated hypertensives that we found in univariate analyses, disappeared after adjustment for potential confounding factors suggests that beta-blockers have no substantial impact on plasma lipid levels in the general Dutch population. Another explanation for not finding an expected relation between the use of solely diuretics or solely beta-blockers could be confounding by contra-indication.…”

“…1 A recent study on diuretics demonstrated that during continuation of diuretics initially elevated lipid concentrations returned to the old level after 1 year. 2 The effects of thiazide diuretics on triglyceride and LDL levels were dose dependent. 3 Beta-blockers decrease HDL choles- ratio ‫؍‬ 5.44).…”

Treatments for Hypertension in Type 2 Diabetes-Non-Pharmacological and Pharmacological Measurements

“…This treatment has beneficial effects on both morbidity and mortality while, previous general concern on the negative impact of diuretics on the different lipid parameters and metabolic effects appear not justified as, all long-term studies with low-dose diuretics have not been shown to affect lipid and glucose profiles in a negative way [161][162][163]. Moreover, in studies of a year or more duration, diuretics have been shown to reduce cardiovascular risk [145,[164][165][166].…”

Preventing Thiazide‐Induced Hyperglycemia: Opportunities for Clinical Pharmacists

“…3,6,[10][11][12][13] The NHLBI working group extensively reviewed the related literature, including observational studies and clinical trials. 9 Although the evidence is somewhat contradictory, it is reasonably clear that the absolute risk for new-onset diabetes slightly increases after thiazide use.…”