“…Thiazide diuretics, which may have antihypertensive effects equivalent to those of indapamide [10][11][12], cause a reduction in extracellular fluid volume [13] and tend to reduce the glomerular filtration rate, probably by direct vasoconstrictive action on the renal vasculature [14], In contrast, short-term studies have shown that indapamide has no harmful effects on renal blood flow or glomerular filtration rate [15,16], and one study showed that the drug may cause an increase in creatinine clearance [17]. How ever, the long-term effect of the drug on renal function has not been evaluated.…”