Diuretic effect and mechanism of action of parsley

Kreydiyyeh, Sawsan Ibrahim; Usta, Jinan

doi:10.1016/s0378-8741(01)00408-1

Cited by 96 publications

(67 citation statements)

References 14 publications

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“…[6][7][8][9][10] Available evidence suggests that some herbal extracts interfere with the concentrating and diluting mechanisms of tubular transport processes in the nephron and/or with other protein components of tubular cell membranes. 11,12 Therefore, any link between OA affecting proximal tubular Na þ reabsorption and secretion would require that the triterpene influences tubular transport protein components or tubular epithelial cells' viability. To examine this possibility, this study also assessed the effects of OA on cell viability on human embryonic kidney (HEK293) and MadinDarby bovine kidney (MDBK) cell lines.…”

Section: Introductionmentioning

confidence: 99%

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

et al. 2012

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Studies indicate that Syzygium spp-derived oleanolic acid (OA) enhances renal function of streptozotocin (STZ)-induced diabetic rats as evidenced by its reversal of the previously reported inability of the kidney to excrete Na þ in these animals. We postulated that OA influences Na þ excretion in the proximal tubule, the site where two-thirds of filtered NaCl is reabsorbed through a process mediated by transport proteins. Therefore, the study investigated the effects of OA on proximal tubular Na þ handling in male Sprague-Dawley rats using renal lithium clearance (C Li ). Renal C Li has been used widely in animal and clinical studies to assess proximal tubular function. Sub-chronic doses of OA were administered to rats twice every third day for 5 weeks. Rats treated with deionized water served as control animals. Cytotoxicity of OA on kidney and liver cell lines was assessed by the MTT and comet assays. OA increased Na þ excretion of conscious male Sprague-Dawley rats from week 3 to week 5. By the end of the 5-week experimental period, OA treatment significantly reduced (p < 0.05) plasma creatinine concentration of STZ-induced diabetic rats with a concomitant elevation in glomerular filtration rate (GFR). Acute OA infusion was also associated with increases in fractional excretion of sodium (FE Na ) and lithium (FE Li ) in anesthetized rats in the absence of significant changes in GFR. The MTT assay studies demonstrated that OA increased the metabolic activity of kidney and liver cell lines. Taken together with previous observations, this study implicates the proximal tubule in OA-evoked increases in urinary Na þ output.

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Section: Introductionmentioning

confidence: 99%

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

et al. 2012

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“…In addition, Cs perfusion incresaed urinary sodium, chloride and potassium levels suggesting a probable inhibition of Na+/K+/2Cl-commonly named as Furosemide like effect. Previous studies have been reported similar diuretic mechanism of plants extract [2,[20][21][22] . We have previously demonstrated that the increase of diuresis was accompanied by a similar qualitative increase of electrolytes after Spergularia purpurea and Retama reatam water extract treatment [9,23] .…”

Section: Discussionmentioning

confidence: 53%

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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Abstract:The purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg −1 h −1 in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cl-and K + were significantly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg −1 h −1 had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Cl-urinary excretion in normal rat. This effect may be mediated via a Furosemide like effect.

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“…Rats offered an aqueous parsley seed extract to drink, eliminated a significantly larger volume of urine per 24 h as compared to when they were drinking water. The mechanism of action of parsley seems to be mediated through an inhibition of the Na + -K + pump that would lead to a reduction in Na + and K + reabsorption leading thus to an osmotic water flow into the lumen, and dieresis [26]. Table 4 Erythrocyte antioxidant status and oxidative stress in the control (I) and the experimental groups of rats (II-control supplemented with 5% "Vitalplant" mixture fed group; III-high-fat fed group; IV-high-fat supplemented with 5% "Vitalplant" mixture fed group; V-high-fat fed for 6 weeks and high-fat supplemented with 5% "Vitalplant" mixture for 8 weeks fed group) after 14 weeks of experiment.…”

Section: Discussionmentioning

confidence: 99%

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

et al. 2015

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BACKGROUND: “VITALPLANT” medicinal plant mixture, aimed at body weight regulation and metabolism enhancement was formulated in order to be incorporated as an ingredient in functional food formulations on the basis of known biological activity of the alder buckthorn bark, peppermint, caraway and parsley. METHODOLOGY: The body weight-lowering potential, hypolipidemic effects and antioxidant activity of “Vitalplant” mixture were examined on five groups of male Wistar rats on different food regimes for 14 weeks. RESULTS: “Vitalplant” mixture supplementation caused an increase in food intake, but induced a decrease in body weight gain. The lipid status and atherogenic index (AI) were significantly improved in “Vitalplant” mixture supplemented hyperlipidemic (HF) groups in comparison to HF group. “Vitalplant” mixture was able to influence the activity of antioxidant enzymes and to protect erythrocytes of the rats fed the HF diet from oxidative damage, which was indicated by significantly lower malondialdehyde (MDA) levels in “Vitalplant”- HF groups in comparison to the HF group. CONCLUSION: “Vitalplant” mixture seemed to be beneficial for the reduction of body weight and improvement of antioxidant status of the erythrocytes, and its antihyperlipidemic property was highly active for enhancing the profile of plasma lipids in rats.

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Diuretic effect and mechanism of action of parsley

Cited by 96 publications

References 14 publications

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

The Effects ofSyzygium aromaticum-Derived Oleanolic Acid on Kidney Function of Male Sprague–Dawley Rats and on Kidney and Liver Cell Lines

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Antihyperlipidemic, antioxidant and weightlowering effects of “Vitalplant”

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