Diuretic-Associated Hypomagnesemia in the Elderly

Martin, B. J.; Milligan, Karen

doi:10.1001/archinte.1987.00370100082014

Cited by 53 publications

(12 citation statements)

References 15 publications

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“…Lower excretions in healthy controls have also been documented by other investigators [39,49]. Lower Mg excretions have also been reported for hypomagnesemic elderly subjects on diuretics during a period of low Mg intake [48). Conversely, higher excretions than reported in this study were obtained by Malini et al [26) in a group of hypertensives on various combinations of antihypertensive agents.…”

Section: Magnesium Blood Concentrations the Levels Of Serumsupporting

confidence: 88%

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Magnesium supplementation in patients with congestive heart failure.

Costello

Moser-Veillon

DiBianco

1997

Journal of the American College of Nutrition

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Supplementation with 10.4 mmol oral magnesium daily for 3 months did not significantly alter blood levels or magnesium retention; however, patients demonstrated lower retention of magnesium after supplementation. Differences in magnesium retention was not related to basal magnesium intake, blood levels or excretion. Unfortunately, even an intensive effort at characterizing magnesium status did not identify a clinical indicator of utility for differentiating patients with congestive heart failure before, during, and after 3 months of magnesium supplementation.

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Section: Magnesium Blood Concentrations the Levels Of Serumsupporting

confidence: 88%

“…Alterations in concentrations of Mg in the blood may [26,28,38,48] or may not [14,16,19,26] be affected by concomitant administration of diuretics, or angiotensin converting enzyme inhibitors [17,18,20,26]. Controlled trials suggest that diuretics playa role in causing Mg deficiency.…”

Section: Magnesium Blood Concentrations the Levels Of Serummentioning

confidence: 99%

Magnesium supplementation in patients with congestive heart failure.

Costello

Moser-Veillon

DiBianco

1997

Journal of the American College of Nutrition

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“…Over the last years, small studies have shown that thiazide use impairs the magnesium-retaining ability of the kidney which may result in a magnesium deficiency. [19][20][21][22] However, the effect of longterm thiazide use on serum magnesium levels is still unknown. We showed that the use of thiazide diuretics was associated with lower serum magnesium of 0.018 mmol/L.…”

Section: Discussionmentioning

confidence: 99%

Thiazide but not loop diuretics is associated with hypomagnesaemia in the general population

Kieboom

Zietse

Ikram

et al. 2018

Pharmacoepidemiology and Drug

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“…Loop diuretics and potassiumsparing diuretics do not significantly alter serum magnesium. [26] In any case, however, it has not been proved that hypomagnesaemia does in fact increase morbidity or mortality among the elderly. [27] Incidentally, hypokalaemia lowers insulin secretion and hence reduces glucose tolerance.…”

Section: Hypokalaemiamentioning

confidence: 99%

Metabolic Adverse Reactions to Diuretics Clinical Relevance to Elderly Patients

et al. 1995

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There is a wide variety of diuretic-induced metabolic abnormalities of unequal severity. Renal failure can be caused by excessive sodium loss, or by certain drug combinations comprising, for instance, a nonsteroidal anti-inflammatory drug (NSAID) or an ACE inhibitor. Hyponatraemia is uncommon. It is encountered with thiazides, especially among women. A sodium level less than 120 mmol/L may result in neurological complications. Hypokalaemia is frequent and might increase the risk of cardiac arrhythmia. Hyperkalaemia induced by potassium-sparing diuretics is often combined with another contributive cause. Glucidic, lipidic and uric acid abnormalities are common, but their clinical effects are slight. They do not seem to worsen cardiovascular risks among elderly patients. Nevertheless, prescribing diuretics for elderly patients requires special precautions. Reducing the diuretic dose, as is now recommended for treating hypertension, seems to lessen adverse effects, and despite all the adverse reactions just mentioned, it has been proven that diuretics are beneficial in many diseases.

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Diuretic-Associated Hypomagnesemia in the Elderly

Cited by 53 publications

References 15 publications

Magnesium supplementation in patients with congestive heart failure.

Magnesium supplementation in patients with congestive heart failure.

Thiazide but not loop diuretics is associated with hypomagnesaemia in the general population

Metabolic Adverse Reactions to Diuretics Clinical Relevance to Elderly Patients

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