Diuretic activity of the stem-bark extracts of Steganotaenia araliacea hochst [Apiaceae]

Agunu, A; Abdurahman, E. M.; Andrew, G.O.; Muhammed, Zayyanu

doi:10.1016/j.jep.2004.09.045

Cited by 31 publications

(20 citation statements)

References 9 publications

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“…In addition, Cs perfusion incresaed urinary sodium, chloride and potassium levels suggesting a probable inhibition of Na+/K+/2Cl-commonly named as Furosemide like effect. Previous studies have been reported similar diuretic mechanism of plants extract [2,[20][21][22] . We have previously demonstrated that the increase of diuresis was accompanied by a similar qualitative increase of electrolytes after Spergularia purpurea and Retama reatam water extract treatment [9,23] .…”

Section: Discussionsupporting

confidence: 51%

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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Abstract:The purpose of this study was to examine the diuretic effect of the aqueous extract of Capparis spinosa (Cs) at a dose of 500 mg kg −1 h −1 in normal rats. The aqueous extract was administred intravenously and the diuresis was followed within four hours after starting the treatment. Intravenous administration of aqueous Cs extract produced a significant increase on diuresis (p<0.001) and glomerular filtration rate from the second hour of treatment to the fourth hour (p<0.001). In addition, urinary Na+, Cl-and K + were significantly increased after two hours of Cs perfusion (p<0.01). Furosemide at a dose of 0.1 mg kg −1 h −1 had similar effect when compared to Cs administration. We conclude that the water extract of Cs fruit exhibited a significant diuretic effect accompanied by in crease in Na+, K+ and Cl-urinary excretion in normal rat. This effect may be mediated via a Furosemide like effect.

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Section: Discussionsupporting

confidence: 51%

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Zeggwagh¹,

Michel²,

Sulpice³

et al. 2007

American J. of Pharmacology and Toxicology

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“…Druginduced diuresis is useful in many life-threatening disease conditions such as congestive heart failure (CHF), hypertension, nephritis and pregnancy toxemia. 1 Most diuretic drugs have been associated with numerous adverse effects such as electrolyte imbalance, development of new-onset diabetes, metabolic alterations, activation of the renin-angiotensin and neuroendocrine systems and impairment of sexual function. 2 In this scenario, the need for novel diuretics such as plant-based substances, which are considered to be relatively safe and possessing lower potential for adverse effects, is advocated.…”

Section: Introductionmentioning

confidence: 99%

Diuretic activity of ethanolic extract of whole plant of Sphaeranthus indicus linn in albino rats

Sundaresan

Prabhakaran

Palappallil

et al. 2017

Int J Basic Clin Pharmacol

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Background: Sphaeranthus indicus Linn (S. indicus Linn) is a medicinal plant widely used in Indian traditional system of medicine for treating various ailments. The aim of the study was to evaluate diuretic activity by Lipschitz method in albino rats.Methods: Thirty albino rats were grouped into five groups and each contained six rats. Group I (control group) received 25ml/kg each of 0.9% sodium chloride orally. Group II (standard) received Hydrochlorothiazide 25 mg/kg orally dissolved in isotonic normal saline. Groups III, IV and V received ethanolic extracts of S. indicus Linn in doses 100mg/kg, 200mg/kg and 300mg/kg respectively dissolved in isotonic saline orally. The mice were put in metabolic cages and urine samples were collected for all the groups up to 24 hours after dosing. Urine was analysed for volume, urinary excretion ratio, diuretic activity, sodium and potassium composition electrolytes. Data was analysed using SPSS version 16 for windows.Results: Single dose administration of S. indicus in doses of 100, 200 and 300 mg/Kg as compared to Hydrochlorothiazide (25 mg/kg)have significantly (p<0.001, ANOVA) increased total urine output along with an increase in concentration of sodium and potassium. S. indicus Linn 300 mg/Kg produced greater diuretic activity, which is comparable to the effect of standard.Conclusions: The extract treated rats showed a dose dependent increase in urine volume. Maximum diuretic and kaliuretic activity were observed at the dose of 300 mg/kg of the extract. The present study supports and confirms the basis for folklore use of S. indicus Linn as a diuretic agent.

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“…Drug that induced diuresis is beneficial in many life threatening disease conditions such as congestive heart failure, nephritic syndrome, cirrhosis, renal failure, hypertension, and pregnancy toxaemia. 7 Most diuretic drugs have the adverse effect on quality of life including impotence, fatigue and weakness. Naturally occurring diuretics include caffeine in coffee, tea, and cola, which inhibit Na+ reabsorption and alcohol in beer, wine and mixed drinks, which inhibit secretion of ADH 8,9 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Locomotor and Diuretic Activities of Aqueous and Alcoholic Extracts of Leaves of Epipremnum Aureum L.

Gowlikar¹,

Shalini²,

Benazir³

et al. 2016

Int. Res. J. Pharm.

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The aim of the present study was to evaluate the locomotor and diuretic activities of both aqueous and alcoholic extracts of leaves of Epipremnum aureum (AQEEa and ALEEa) in experimental animals. Locomotor activity was evaluated by actophotometer and diuretic activity was evaluated using Lipschitz test model in rats. Preliminary phytochemical screening showed the presence of alkaloids, flavonoids, terpenoids and saponins. Intra peritoneal administration of AQEEa and ALEEa at doses 200mg/kg produced significant (P< 0.01) CNS depression by reducing locomotor activity while it showed a significant (P< 0.01) increase in the urine volume when compared to control. Thus, in conclusion the AQEEa and ALEEa have a significant CNS depression action by reducing locomotor and diuretic action in rats.

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Diuretic activity of the stem-bark extracts of Steganotaenia araliacea hochst [Apiaceae]

Cited by 31 publications

References 9 publications

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Cardiovascular Effect of Capapris spinosa Aqueous Extract in Rats. Part II: Furosemide-like Effect of Capparis spinosa Aqueous Extract in Normal Rats

Diuretic activity of ethanolic extract of whole plant of Sphaeranthus indicus linn in albino rats

Evaluation of Locomotor and Diuretic Activities of Aqueous and Alcoholic Extracts of Leaves of Epipremnum Aureum L.

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