Diuretic activity of some Withania aristata Ait. fractions

Evaluation of Diuretic Activity of Different Solvent Fractions of Methanol Extract of Carissa edulis Root Bark in Rats

“…The diuretic activity may be produced by stimulating vasodilatation thereby increasing renal blood flow [53], or by producing inhibition of tubular reabsorption of water and anions [54]. However, at present, we do not have evidence in favor or against the operation of such potential mechanism of diuresis.…”

Withanolides from Whitania aristata and their diuretic activity

“…The leaves of flowering and immature fruiting plants of Whitania aristata were collected from the Santa Cruz Coast in a location -Herrera et al, 2007-Herrera et al, , 2008.…”

“…On the other hand, previous studies by our group have shown that the aqueous and methanol extracts, and fractions obtained from the methanol extract, produced important diuretic activity in rats (Martín-Herrera et al, 2007, 2008. So, in order to identify the compounds responsible for this activity, the whole dry plant material collected was submitted to successive extractions with different polar solvents, and two withanolides, one of them not reported previously, were isolated from the fraction that had shown the most diuretic activity.…”

Phytoconstituents and diuretic activity of Cymbopogon citratus leaf infusions in humans

“…In the same vein, increase calciuresis and decrease thiazide secreting index exclude thiazide (hydrochlorothiazide) mode of action [22,24] . Osmotic diuresis is unlikely to be operative, since the extract has a low Na + content, and ingestion of the infusion produced no significant effect on the urine specific gravity and osmolarity, though a high concentration of K + was detected in the extract [20] .…”

“…Therefore, the non-significant changes in eGFR observed in the acute phase of the present study provide additional evidence to support the loop-active diuretic (furosemide-like) mode of action of C. citratus leaf infusion. The possible carbonic anhydrase inhibition, thiazide mode of action, osmotic diuretic effects and action of anti-diuretic hormone were excluded in the present study due to the absence of their biochemical indicators [22] . For instance, the observed increase in Cl -/(Na + +K + ) ratio (index of decreased carbonic anhydrase inhibitory activity) [23] ruled out carbonic anhydrase inhibition (acetazolamide-like) mode of action.…”