Dithranol

Gerritsen, M.J.P.

doi:10.1002/9780470987421.ch10

Textbook of Psoriasis 2003

DOI: 10.1002/9780470987421.ch10

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Dithranol

M.J.P. Gerritsen¹

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2010

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Cited by 3 publications

(2 citation statements)

References 75 publications

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“…Since the beginning of the twentieth century, dithranol has been used in the treatment of psoriasis 11 . Dithranol produces a dose‐dependent inflammatory reaction in the skin, which is required for the therapeutic effect.…”

mentioning

confidence: 99%

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

Kerkhof

Valk

Swinkels

et al. 2006

British Journal of Dermatology

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The hypothesis that calcipotriol ointment might be at least as effective as dithranol cream in the day-care setting could not be proven in the present study. Whereas calcipotriol has become a mainstay in the routine outpatient treatment of psoriasis not requiring a day-care setting, dithranol treatment, being difficult as a routine outpatient therapy, has increased efficacy and improved tolerability if the treatment is carried out in a day-care setting.

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mentioning

confidence: 99%

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

Kerkhof

Valk

Swinkels

et al. 2006

British Journal of Dermatology

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“…Calcipotriol is well tolerated and can be regarded as a safe treatment, provided that patients do not use > 100 g of the formulations per week. Dithranol has been used in the treatment of psoriasis since the beginning of the twentieth century 6 . A 24‐h inpatient treatment with dithranol in ointment or paste is effective, and is considered to be the gold‐standard dithranol treatment.…”

mentioning

confidence: 99%

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: quality-of-life outcomes of a randomized controlled trial of supervised treatment of psoriasis in a day-care setting

Korte

Valk

Sprangers

et al. 2007

British Journal of Dermatology

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The hypothesis was confirmed, that no statistically significant differences in improvement of quality of life could be found between calcipotriol ointment and dithranol short-contact cream in a day-care setting. Given this result, both calcipotriol and dithranol can be welcome alternatives for the patient. Calcipotriol, being more practical and patient friendly, can be considered as a first-line approach in clinical practice. However, in patients recalcitrant to calcipotriol and/or other topical treatments, preference should be given to the dithranol regimen. Topical treatment in combination with interventions explicitly focusing on improvement of coping behaviour and psychosocial functioning may further increase the degree of improvement in the psychosocial domains of quality of life. The results of this study are likely to give further evidence to the notion that the generic SF-36 is little or not responsive to small to moderate changes in quality of life in mild to moderate psoriasis.

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Topical Delivery of a Naproxen-Dithranol Co-drug: In Vitro Skin Penetration, Permeation, and Staining

2010

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Dithranol

Cited by 3 publications

References 75 publications

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: a randomized controlled trial of supervised treatment of psoriasis vulgaris in a day-care setting

A comparison of twice-daily calcipotriol ointment with once-daily short-contact dithranol cream therapy: quality-of-life outcomes of a randomized controlled trial of supervised treatment of psoriasis in a day-care setting

Topical Delivery of a Naproxen-Dithranol Co-drug: In Vitro Skin Penetration, Permeation, and Staining

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