Diterpenoids with antitumor activity from Euphorbia esula L.

Sulyok, Edvárd; Vasas, Andrea; Rédei, Dóra; Forgó, Péter; Zupkó, István; Molnár, J.; Hohmann, Judit

doi:10.1055/s-0029-1234578

Cited by 5 publications

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“…Some diterpenoids from the genus Euphorbia have been found to have the potential of anti‐HIV . One of them named Prostratin is expected to be a potential induction adjunct to HAART.…”

Section: Resultsmentioning

confidence: 99%

Terpenes from Euphorbia antiquorum and Their in Vitro Anti‐HIV Activity

Dong

Chen

et al. 2018

Chemistry & Biodiversity

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Three new compounds (1 - 3), including two euphane type triterpenes, 24,24-dimethoxy-25,26,27-trinoreuphan-3β-ol (1) and (24S)-24-hydroperoxyeupha-8,25-dien-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α,16α,17-triol (3), were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4 - 11). The structures of compounds (1 - 11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC = 1.38 μm).

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“…Some diterpenoids from the genus Euphorbia have been found to have the potential of anti‐HIV . One of them named Prostratin is expected to be a potential induction adjunct to HAART.…”

Section: Resultsmentioning

confidence: 99%

Terpenes from Euphorbia antiquorum and Their in Vitro Anti‐HIV Activity

Dong

Chen

et al. 2018

Chemistry & Biodiversity

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“…The genus is well known for producing macrocyclic diterpenoid polyesters such as the ingenane, − jatrophane, − paraliane, ,, and segetane ,,, diterpenoids. Euphorbia esula L. plants are distributed throughout China and are used in traditional Chinese medicine to treat cancer, swelling, and warts. , A number of diterpenoids with a wide spectrum of bioactivities, including antiproliferative, cytotoxic, skin irritating, tumor promoting, antiviral, and antibacterial effects ,− have previously been isolated from this species. In a continuing search for novel bioactive compounds from the genus Euphorbia , , 16 new diterpenoids ( 1 – 16 ) and six known analogues were identified from extracts of the twigs of E. esula .…”

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confidence: 99%

Euphorbesulins A–P, Structurally Diverse Diterpenoids from Euphorbia esula

Zhou

Dalal

et al. 2016

J. Nat. Prod.

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Aqueous ethanol extracts of powdered twigs of Euphorbia esula afforded 16 new diterpenoids, named euphorbesulins A-P. These euphorbesulins included presegetane (1-3), jatrophane (4-14), paraliane (15), and isopimarane (16) diterpenoids as well as six known analogues. Compounds 1-3 represent a rare type of presegetane diterpenoid. Their structures were determined by analysis of the spectroscopic data, and the absolute configuration of 1 was established by X-ray crystallography. Diterpenoid 7 showed low nanomolar antimalarial activity, while the remaining compounds showed only moderate or no antimalarial activity.

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“…E uphorbia esula L. (Euphorbiaceae), a famous Chinese herbal medicine, is used as a diuretic and to remove edema. It is widely distributed in China and commonly used to treat cancer, warts, and swelling. − Previous phytochemical studies of E. esula L. have led to the identification of numerous diterpenoids belonging to the jatrophane, − lathyrane, and ingenane classes . Some of these compounds show diverse biological properties, including antiproliferative, multidrug-resistance-modulating, antimicrobial, and antichikungunya virus activities. − As a continuation of research on new and bioactive diterpenoids from Chinese herbs, − a systematic investigation of E. esula L. resulted in the identification of 18 new jatrophane diterpenoids, euphoesulatins A–R ( 1 – 18 ), and three known diterpenoids ( 19 – 21 ).…”

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confidence: 99%

“…1 H NMR and13 C NMR Data ofCompounds 15 and 16 Recorded in CDCl 3 ( 1 H NMR 500 MHz,13 C NMR 125 MHz).…”

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Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

et al. 2020

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Eighteen new jatrophane diterpenoids, euphoesulatins A–R (1–18), and three known diterpenoids (19–21) were isolated from Euphorbia esula. Compounds 1–7, 14, and 18 represent a rare type of jatrophane-type diterpenoid containing a nicotinoyloxy group. The absolute configuration of 1 was determined by X-ray crystallography. The compounds were assayed for their antiosteoporotic activity in a bone-marrow-derived macrophage cell line, and compounds 1, 8, and 10 significantly inhibited the formation of osteoclasts, with IC50 values of 1.2, 3.5, and 2.3 μM, respectively. These three compounds also dose-dependently reduced the activity of nuclear factor activated T-cell cytoplasmic 1. This study reveals the antiosteoporotic effects of jatrophane diterpenoids for the first time.

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Diterpenoids with antitumor activity from Euphorbia esula L.

Cited by 5 publications

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Terpenes from Euphorbia antiquorum and Their in Vitro Anti‐HIV Activity

Terpenes from Euphorbia antiquorum and Their in Vitro Anti‐HIV Activity

Euphorbesulins A–P, Structurally Diverse Diterpenoids from Euphorbia esula

Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis

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