Diterpenoids from the Roots of Salvia yunnanensis

Abstract

Two new diterpenoids, salyunnanins I and J (1 and 2), together with ten analogues, were isolated from the roots of Salvia yunnanensis. The structures of the new isolates, possessing different neo-clerodane and seco-abietane diterpenoid skeletons respectively, were elucidated on the basis of comprehensive spectroscopic data. All of the compounds were tested for the inhibitory activities against six human tumor lines in vitro, and several ones showed moderate cytotoxic activities.Graphical AbstractElectronic supplementary materialThe online version of this article (doi:10.1007/s13659-015-0080-4) contains supplementary material, which is available to authorized users.

Isoprenylated Flavonoids as Cav3.1 Low Voltage-Gated Ca2+ Channel Inhibitors from Salvia digitaloides

“…Our group has been committed into the phytochemical studies of genus Salvia since 2000, and discovered a series of novel terpenoids with diverse structures and bioactivities [9][10][11][12][13][14]. As a part of our ongoing research about the plants of Salvia species from southwestern China, unexpectedly, three new isoprenylated flavonoids saldigones A-C (1, 3, 4) (Fig.…”

“…The presence of a flavanone skeleton was evident from the characteristic absorption bands at λ max 345 and 297 nm in the UV spectra, the ABX-type spin system (δ H 5.26, 1H, dd, J = 12.8, 3.0 Hz, H-2; 2.78, 1H, dd, J = 17.0, 3.0 Hz, H-3α; and 2.97, 1H, dd, J = 17.0, 12.8 Hz, H-3β) in the 1 H NMR spectrum (Table 1), conjugated with the oxygenated carbon resonance at δ C 78.8 (C-2), a methylene resonance at δ C 43.6 (C-3), and a carbonyl resonance at δ C 196.7 (C-4) in the 13 C NMR spectra [23][24][25]. The 13 The locations of these oxygenated substituents as well as the isoprenyl and methyl groups were determined by the HSQC and HMBC experiments (Fig. 2 Biogenetically, flavanones are formed by cyclization of chalcones mediated by the enzyme chalcone isomerase (CHI) in a highly stereospecific manner through a Michael nucleophilic reaction involving the 2′-OH group and the α, β-unsaturated ketone of the chalcone, leading almost exclusively to the (2S)-isomer [26,27].…”

Salvianolic acid A & B: potential cytotoxic polyphenols in battle against cancer via targeting multiple signaling pathways

“…From the aqueous root extract of Salvia yunnanensis , two known polyphenols were isolated salvianolic acid A and lithospermic acid 18. Salvia yunnanensis is also a traditional Chinese herb used as a substitute of Salvia miltiorrhiza 19 (Figure 1).…”

The complete chloroplast genome sequence of the medicinal plant Salvia yunnanensis C. H. Wright. (Lamiaceae)

“…In some areas of southwest China, Salvia yunnanensis is a local medicine commonly used as the surrogate of the traditional Chinese medicine Radix et Rhizoma Saliviae Miltiorrhizae (Danshen, Salvia miltiorrhiza) for the treatment of various cardiovascular diseases (Jiangsu New Medical College 1977). However, up to now, for such a medicinal plant, studies have focussed on describing its chemical compositions (Xu et al 2006;Xiang et al 2013;Xia et al 2015) and DNA barcoding analysis (Wang and Wang 2005;Wang et al 2007), with little involvement in its genomes. Here, we report the chloroplast (cp) genome sequence of S. yunnanensis and find its internal relationships within the family Lamiaceae.…”

“…2013 ; Xia et al. 2015 ) and DNA barcoding analysis (Wang and Wang 2005 ; Wang et al. 2007 ), with little involvement in its genomes.…”