Diterpenoids from the roots of Croton crassifolius and their anti-angiogenic activity

Wang, Jia-Jian; Chung, Hau Yin; Zhang, Yubo; Li, Guoqiang; Li, Yao-Lan; Huang, Weihuan; Wang, Guo‐Cai

doi:10.1016/j.phytochem.2015.12.011

Cited by 41 publications

(43 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8, Table S2 †). Compounds of this type have been isolated from plants of the families Euphorbiaceae, 44,78,105,107,109,[111][112][113][114][136][137][138][139][140][141][142][143][144][145][146][147][148][149][150][151] Compositae, 45 Annonaceae, 122 Lamiaceae, 91 Jungermanniaceae, 152,153 Asteraceae, 76 and Meliaceae, 154 and in sponges of genus Agelas. 79,135 Among them, chettaphanin II (102) 111 is found.…”

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

“…The structure and absolute conguration of lactone 106 were corroborated by synthesis and it shows a moderate activity against HeLa cells. 44,78,112,141 Crotohalimaneic acid (107) and crotohalimoneic acid (108) show activity against several human cancer cell lines. 140 The structure of crotohalimoneic acid (108) was corroborated by X-ray.…”

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

“…A series of ent-halim-5(10)-enes known as crassifolins 112-117, 119-121, 123-124 and crassin C (125) has been isolated from Croton crassifolius. 44,78,144 The absolute conguration of several of them was conrmed by CD. The structure of crassifolin D (114) was corroborated by X-ray; however, its absolute conguration was not determined.…”

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

“…Nowadays, the biological activities of these compounds (such as antitumour, [44][45][46][47][48] anti-inammatory, 49 antimicrobial, [50][51][52] antifungal, 53 germination inhibitors 54 ) are being studied from different points of view. Compounds such as tuberculosinol, 55,56 isotuberculosinol [57][58][59] and analogues ( Fig.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

View full text Add to dashboard Cite

Covering: 1970 to 2017 Diterpenes with a halimane skeleton constitute a small group of natural products that can be biogenetically considered as being between labdane and clerodane diterpenoids. Some of these compounds show biological activities, such as antitumour, mosquito repellency, germination inhibition and antimicrobial, as well as being biomarkers for tuberculosis. To the best of our knowledge, there are no reviews on these compounds. In this review, halimane skeleton diterpenoids are classified according to their biogenetic origin, characterization and/or the enzymes involved in their biosynthesis. Herein, a review of their synthesis or synthetic approaches is communicated.

show abstract

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

Section: Halim-5(10)-enes Groupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Halimane diterpenoids: sources, structures, nomenclature and biological activities

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Ten antiangiogenic drugs (seven small kinase inhibitors, two antibodies, and one fusion protein) are approved by Food and Drug Administration for multiple cancer indicators (Jayson, Kerbel, Ellis, & Harris, ). Currently, exploring antiangiogenic agent from natural products is emerging as an important research field, and many antiangiogenic natural products with diverse molecular structures have been discovered (Guan, Liu, Luan, et al, ; Guan, Luan, Lu, et al, ; Huang, Liang, Wang, et al, ; Huang, Wang, Liang, et al, ; Luan, Gao, Guan, et al, ; Wang, Chung, Zhang, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling

Liu

Cai

Gao

et al. 2017

Phytotherapy Research

View full text Add to dashboard Cite

Alantolactone (ALA), a sesquiterpene lactone isolated from several medicinal plants such as Inula helenium, has been identified to have attractive anticancer activity. However, its role in the inhibition of angiogenesis during tumor development remains unclear. In this study, we found ALA can inhibit the proliferation, motility, migration, and tube formation of human umbilical vein endothelial cells. ALA also restrained angiogenesis in chick embryo chorioallantoic membrane and delayed the growth of human MDA-MB-231 breast cancer xenograft in mice through angiogenesis inhibition. Furthermore, ALA suppressed the phosphorylation of vascular endothelial growth factor receptor 2 and its downstream protein kinase including PLCγ1, FAK, Src, and Akt in endothelial cells. Taken together, the antiangiogenic activity of ALA and its molecular mechanism are identified for the first time, indicating that ALA may be a potential drug candidate or lead compound for antiangiogenic cancer therapy.

show abstract

Synthesis of 1‐Phospho‐3‐benzoxepins via a Silver‐catalyzed Reaction of 2‐Alkynylacetophenones with Diazomethylphosphonates

et al. 2023

View full text Add to dashboard Cite

A synthetic protocol for construction of 3-benzoxepin skeleton through a silver-catalyzed annulation/nucleophilic/ring-expansion reaction of 2-alkynylacetophenones with diazomethylphosphonates is described. This protocol provided a series of 1-phosphonate-3-benzoxepin analogs in yields of 39%-95%. The resulting benzoxepins featuring halogen and phosphonate could be further transformed into other derivatives.

show abstract

Diterpenoids from the roots of Croton crassifolius and their anti-angiogenic activity

Cited by 41 publications

References 24 publications

Halimane diterpenoids: sources, structures, nomenclature and biological activities

Halimane diterpenoids: sources, structures, nomenclature and biological activities

Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling

Synthesis of 1‐Phospho‐3‐benzoxepins via a Silver‐catalyzed Reaction of 2‐Alkynylacetophenones with Diazomethylphosphonates

Contact Info

Product

Resources

About