Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb

Norditerpenoid alkaloids from Aconitum and Delphinium: structural relevance in medicine, toxicology, and metabolism

“…The possible rearrangement of the C18 NDA structures led to a discussion of their probable biosynthetic pathway. 85 The global profiling of NDA in A. stapfianum and analysis of the basis of its use for detoxification of fu'zi has been reported. 86 The analysis was performed by UPLC/Q-TOF-(ESI)-MS with fragmentation patterns from MS/MS spectra as this is a method of high sensitivity, selectivity, and analytical speed.…”

Prediction of the taxonomical classification of theRanunculaceaefamily using a machine learning method

“…In particular, four genera (Aconitum, Delphinium, Trollius and Cimicifuga genera) of the subfamily Helleboroideae clustered together, in which Aconitum and Delphinium formed the closest cluster and was grouped into the diterpenoid alkaloidcontaining group. [43][44][45] The diterpenoid alkaloids have been suggested to be the chemical markers of Aconitum and Delphinium genera. 46 We also observed that Aquilegia showed a close relationship with Aconitum and Delphinium in the clustering map.…”

C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities

“…Two C 18 -DAs with an unusual E ring similar to acoseptine-type C 19 -DA were also reported, 74 namely, barpubenines A and B (114 and 115) from A. barbatum var . puberulum , 75 in which the C (7) –C (17) bond was rearranged to a C (8) –C (17) bond, forming an additional ketone at C-7. In addition, barpubenine A is the only N -oxide in C 18 -DAs.…”

“…Consistent results were obtained in a recent study which showed that N -acetylsepaconitine (40) could significantly prolong the ventricular premature (VP) action in aconitine-induced arrhythmia mice, with an effect better than that of lappaconitine, while their inhibition of ventricular tachycardia (VT) and ventricular flutter (VFL) was similar. 75 From the data available, the presence of amino or anthranoyl groups at the C-18 position is required for the antiarrhythmic activity of C 18 -DAs, and their antiarrhythmic action is closely related to the methoxyl groups at C-1, C-14, and C-16, along with the hydroxyl group at C-8. Therefore, more efficient antiarrhythmic agents using available natural C 18 -DAs as lead compounds could be designed based on SAR analysis.…”