Diterpenoid alkaloids

Diterpenoid Alkaloids from the Chinese Traditional Herbal “Fuzi” and Their Cytotoxic Activity

“…C-1'), 129.8 (C-2', C-6'), 128.5 (C-3', C-5'), 133.2 (C-4'). NMR data were in accordance with those reported in the literature [10], which established that the isolated compound 5 was deoxyaconitine.…”

“…The structures of isolated alkaloids were confirmed by the spectral analysis utilizing UV, IR, MS, and NMR, and comparison with the published data. Among them chasmanine (2), oxonitine (4) and 15-acetylsongoramine (10) were isolated for the first time from this medicinal plant. The cytotoxicity of isolated compounds was tested against several human cancer cell lines.…”

“…In order to find more anti-tumor active substances, the secondary roots of Aconitum carmichaeli were phytochemically and pharmacologically investigated to obtain eight aconitine-type C 19 -diterpenoid alkaloids: aconitine (1), chasmanine (2), crassicauline A (3), oxonitine (4), deoxyaconitine (5), hypaconitine (6), mesaconitine (7), senbusine A (8), and two atisine-type C 20 -diterpenoid alkaloids, songoramine (9), 15-cetylsongoramine (10). The structures of isolated alkaloids were confirmed by the spectral analysis utilizing UV, IR, MS, and NMR, and comparison with the published data.…”

Study of the bromination of 1,5-dinitro-3-azabicyclo-[3.3.1]non-6-enes

“…A starting point for interpreting the NMR spectra may be served by the low field broadened doublet (5.73 ppm, 3 J = 6.62 Hz) of the H-6 proton at the carbon atom directly linked with halogen, and the singlet of the N-methyl group protons at 3.59 ppm, which have correlation peaks 1 J CH in the 2D HSQC spectrum with the signals of the carbon atoms at 53.06 and 55.01 respectively, and also cross peaks 2 J CH in the HMBC spectrum H-6/C (7) , H-6/C (5) and 3 J CH H-6/C (9) , H-6/C (8) , Me/C (4) , Me/C (2) , and Me/C (7) ( Table 2). The presence of a vicinal coupling constant between the protons of the methyl group and the C (7) atom indicates the formation in the molecule of a covalent bond between the C (7) -N (3) atoms.…”

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Derivatives of azabicyclo[3.3.1]nonane possess various biological activities [1][2][3], consequently broadening the range of compounds of this class is urgent and offers promise for the directed synthesis of biologically active substances and the study of structure-activity relationships. One of the methods of functionalizing the derivatives of 1,5-dinitro-3-azabicyclo[3.3.1]non-6-enes previously synthesized by us [4][5][6][7][8] may be the addition of electrophilic reagents at the double bond.

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