Diterpenes from the brown alga Dictyota mertensii

Pinheiro, Ana Débora Nunes; Lopes-Filho, Erick Alves Pereira; Netto, Annibal Duarte Pereira; Teixeira, Valéria Laneuville

doi:10.1016/j.bse.2019.103926

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Overall, the data showed that FN is a nanoparticle with the potential to be used as an antitumor, immunomodulatory, and antibacterial agent [111]. Pachydictyol A (14), isopachydictyol A (17), dictyol B acetate (18), dictyol C (24), and dictyol B (77) were isolated from D. mertensii [112].…”

Section: Dictyota Mertensii (C Martius) Kützing 1859mentioning

confidence: 98%

“…GC-MS analysis of the unsaponifiable algal petroleum ether extract revealed the presence of eight further compounds, including 2,2,6,7-tetramethyl-10-oxatricyclo[4.3.0.1(1,7)]decan-5-one (115), N-(4-bromo-n-butyl)-piperidin-2-one (116) and tert-hexadecanethiol (117) (Figure 5). The crude algal extract was potently active against the breast carcinoma tumor cell line, MCF7 (IC 50 = 0.6 µg/mL); pachydictyol B (110) and dictyol E (112) showed weak antimicrobial properties, while the other compounds were inactive. Pachydictyol B (110) and pachydictyol C (111) demonstrated a weak and unselective cytotoxicity against twelve human tumor cell lines with a mean IC 50 of >30.0 µM [61].…”

Section: Dictyota Crenulata J Agardh 1847mentioning

confidence: 99%

“…The dichloromethane and dichloromethane/methanol extracts of D. fasciola showed noteworthy growth inhibition of marine bacteria and microalgae. Dictyol C (24), sanadaol (36), acetyldictyolal (37), dictyol E (112), neodictyolactone (220), and 18-hydroxy-2,7dolabelladiene (221) (Figure 9) were found in the crude extracts of D. fasciola collected from northern Tunisia [92].…”

Section: Dictyota Fasciola (Roth) Jv Lamouroux 1809mentioning

confidence: 99%

“…Among the compounds tested, spiralyde A (259) was the most active agent against L. amazonensis and T. cruzi [119]. Dictyol E (112), dolabellane (265), xenicane (266), prenylated guaiane (267), 3,4-epoxy-14-oxo-7,18-dolabelladiene (268), acetoxycrenulide (269), 10,18dihydroxydolabella-2,7-diene (270), 10-acetoxy-18-hydroxydolabella-2,7-diene (271), 1-Ooctadecenoylglycerol (272), and sn-3-O-(geranylgeranyl)glycerol (273) (Figure 10) were identified in Dictyota sp., collected from French and Algerian Mediterranean coastal sites. Compounds 268-269 and 271-273 were screened for their potential to prevent the adhesion of three bacterial strains isolated from marine biofilms in comparison with four commercial antifoulants.…”

Section: Dictyota Spiralis Montagne 1846mentioning

confidence: 99%

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The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

et al. 2022

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Although a broad variety of classes of bioactive compounds have already been isolated from seaweeds of the genus Dictyota, most different species are still chemically and biologically unexplored. Dictyota species are well-known brown seaweeds belonging to the Dictyotaceae (Phaeophyta). The phytochemical composition within the genus Dictyota has recently received considerable interest, and a vast array of components, including diterpenes, sesquiterepenes, sterols, amino acids, as well as saturated and polyunsaturated fatty acids, have been characterized. The contribution of these valued metabolites to the biological potential, which includes anti-proliferative, anti-microbial, antiviral, antioxidant, anti-inflammatory, and anti-hyperpigmentation activities, of the genus Dictyota has also been explored. Therefore, this is the most comprehensive review, focusing on the published literature relevant to the chemically and pharmacologically diverse biopharmaceuticals isolated from different species of the genus Dictyota during the period from 1976 to now.

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Section: Dictyota Mertensii (C Martius) Kützing 1859mentioning

confidence: 98%

Section: Dictyota Crenulata J Agardh 1847mentioning

confidence: 99%

Section: Dictyota Fasciola (Roth) Jv Lamouroux 1809mentioning

confidence: 99%

Section: Dictyota Spiralis Montagne 1846mentioning

confidence: 99%

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The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

et al. 2022

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Antioxidant potentials of polysaccharides derived from marine brown algae

Priya¹,

Khora²

2023

Marine Antioxidants

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Dictyota and Canistrocarpus Brazilian Brown Algae and Their Bioactive Diterpenes—A Review

Georgii,

Teixeira

2023

Marine Drugs

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Dictyotaceae algae have gained recognition as prolific producers of diterpenes, which are molecules with significant biotechnological potential. These diterpenes hold immense promise as potential active drug components, making the algae a compelling area of study. The present review aims to present the latest advancements in understanding the biopotential of Brazilian Dictyota and Canistrocarpus brown algae, shedding light on the remarkable diversity and the biological and pharmacological potential of the secondary metabolites they produce. A total of 78 articles featuring 26 distinct diterpenes are reported in this review, with their antiviral potential being the mosthighlighted biological activity. Despite considerable research on these algae and their diterpenes, significant knowledge gaps persist. Consequently, the present review is poised to serve as a pivotal resource for researchers who are actively engaged in the pursuit of active diterpenes beyond the immediate purview. Furthermore, it holds the potential to catalyze an increase in research endeavors centered around these algal species within the geographical confines of the Brazilian coastline. Also, it assumes a critical role in directing future scientific explorations toward a better comprehension of these compounds and their ecological implications.

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Diterpenes from the brown alga Dictyota mertensii

Cited by 3 publications

References 12 publications

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

The Biodiversity of the Genus Dictyota: Phytochemical and Pharmacological Natural Products Prospectives

Antioxidant potentials of polysaccharides derived from marine brown algae

Dictyota and Canistrocarpus Brazilian Brown Algae and Their Bioactive Diterpenes—A Review

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