Diterpenes from Euphorbia piscatoria: Synergistic Interaction of Lathyranes with Doxorubicin on Resistant Cancer Cells

Reis, Mariana; Paterna, Angela; Mónico, Andreia; Molnár, Joséph; Lage, Hermann; Ferreira, Maria‐José U.

doi:10.1055/s-0034-1383244

Cited by 30 publications

(20 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The diterpene triptolide dose dependently inhibited cell proliferation (IC 50 of 12.7 nM/L), possibly via inhibition of HERV‐K Np9 mRNA and its downstream signalling molecules c‐myc, β‐catenin, ERK, Akt and Notch1 protein in human acute T lymphocytic leukaemia Jurkat cells (Chen et al , ). A number of other antiproliferative diterpenes were also reported by Reis et al (), Pertino et al (), Win et al (), Ma et al () and Ghanadian et al () in a number of human cancer cell lines.…”

Section: Diterpenic Anticancer Traitssupporting

confidence: 53%

Diterpenes and Their Derivatives as Potential Anticancer Agents

Islam

2017

Phytotherapy Research

View full text Add to dashboard Cite

As therapeutic tools, diterpenes and their derivatives have gained much attention of the medicinal scientists nowadays. It is due to their pledging and important biological activities. This review congregates the anticancer diterpenes. For this, a search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases from January 2012 to January 2017 for the published articles. A total 28, 789 published articles were seen. Among them, 240 were included in this study. More than 250 important anticancer diterpenes and their derivatives were seen in the databases, acting in the different pathways. Some of them are already under clinical trials, while others are in the nonclinical and/or pre-clinical trials. In conclusion, diterpenes may be one of the lead molecules in the treatment of cancer. Copyright © 2017 John Wiley & Sons, Ltd.

show abstract

Section: Diterpenic Anticancer Traitssupporting

confidence: 53%

Diterpenes and Their Derivatives as Potential Anticancer Agents

Islam

2017

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The data of the parent skeleton for 2 (Tables 1 and 2) indicated that it was a lathyrane-type diterpenoid. [20] According to the HMBC spectrum, the long-range correlations between H-3 (δ(H) 5.74 (t, J = 3.0, 1 H) and C-1' (δ(C) 167.2 (s)), H-5 (δ(H) 4.50 (br. t, J = 8.5, 1 H)) and C-17…”

Section: Resultsmentioning

confidence: 99%

Five New Diterpenoids from the Seeds of Euphorbia lathyris

Wang

Zhen

Gao

et al. 2018

Chemistry & Biodiversity

View full text Add to dashboard Cite

A new premyrsinane-type diterpenoid, premylanin (1), and four new lathyrane-type diterpenoids named Euphorbia Factors L -L (2-5) were isolated from the seeds of Euphorbia lathyris, together with thirteen known ones (6-18). Their structures were elucidated through spectroscopic analyses, including IR, UV, HR-ESI-MS, 1D- and 2D-NMR. The cytotoxicities of compounds 1-4 and 6-18 against HCT116, MCF-7, 786-0, HepG2 cell lines were evaluated, and compound 13 exhibited considerable cytotoxic activities with an IC values of 6.44, 8.43, 15.3, 9.32 μm, respectively.

show abstract

“…Additional terpenoids from the genus Euphorbia have been isolated, identified, characterized and examined regarding their biological properties by the Molnar-Ferreira collaboration and each has been shown to have distinct properties that inhibited replication, induced apoptosis and inhibited the efflux pump machinery of the mouse lymphoma cell line transfected with the human gene that codes for the Pgp1 transporter (28, 43,44). These studies indicate that the genus Euphorbia is a rich source of terpenoid compounds that have important potential for therapy of multidrug-resistant cancer.…”

Section: Euphorbia Portlandicamentioning

confidence: 99%

Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype

Amaral

Spengler

Molnár

2016

Self Cite

View full text Add to dashboard Cite

Abstract. The focus of this mini-review is to identify non-toxic compounds isolated from natural sources (plants) that exhibit specific activity against efflux pumps of specific multidrugresistant (MDR) cancer cell lines, inhibit proliferation of the MDR cancer cell lines and inhibit the activity of overexpressed efflux pumps of the MDR cancer cell line.Therapy of cancer, if not completely effective, results in the overexpression of genes that code for efflux pumps that extrude the noxious agent (anticancer drug) before it reaches its intended target of the cancer cell (1). The overexpressed efflux pump renders the cancer cell immune to not only the initial drug used in therapy but to a wide range of unrelated noxious compounds (1). The arising of this multidrugresistant (MDR) phenotype makes therapy highly problematic and the end result is that the patient succumbs to the disease (1). Therefore, it is the consensus of many that therapy of MDR cancer may succeed if the responsible efflux pump is inhibited from its activity, therefore, affording the increased concentration of anticancer drug to a level consistent with its toxic targeted action needed to kill the cancer cell. To this extent, over 100,000 synthetic compounds for activity against the known efflux pumps of cancer cell types have been screened by the National Cancer Institute (USA) and, to date, not a single inhibitor has found its way toward successful therapy of MDR cancer. In fact, because normal counter type cells have a fully functional efflux pump, albeit at a much lower level of activity, clinical trials with selected efflux pump inhibitors have produced high toxicity and even death.During the past two decades, traditional medicine has become a source for the identification of plants that harbor compounds that may have important potential for the therapy of cancer. With respect to the laboratory of one of the authors of this mini-review (JM), literally, hundreds of plants have been studied for their activity against specific targets of the cancer cell and it is the focus of this mini-review to identify selected compounds that have no toxicity at the level of their in vitro study and which have activity against proliferation or induction of the apoptotic mechanism or the efflux pump responsible for the phenotype of the MDR cancer cell. Targets of MDR Cancer CellsProliferation. Proliferation is affected by many drugs and, although the search for non-toxic compounds that inhibit proliferation was initiated more than 60 years ago, remains the focus of most studies; however, the inhibition of proliferation by compounds isolated from natural sources will not be discussed here at the level of its mechanism. Rather, suffice to say that our observations for antiproliferative activity as presented in the text remain, for the 5665

show abstract

Diterpenes from Euphorbia piscatoria: Synergistic Interaction of Lathyranes with Doxorubicin on Resistant Cancer Cells

Cited by 30 publications

References 30 publications

Diterpenes and Their Derivatives as Potential Anticancer Agents

Diterpenes and Their Derivatives as Potential Anticancer Agents

Five New Diterpenoids from the Seeds of Euphorbia lathyris

Identification of Important Compounds Isolated from Natural Sources that Have Activity Against Multidrug-resistant Cancer Cell Lines: Effects on Proliferation, Apoptotic Mechanism and the Efflux Pump Responsible for Multi-resistance Phenotype

Contact Info

Product

Resources

About