Diterpenes and Phenylpropanoids from Clerodendrum splendens

Faiella, Laura; Temraz, Abeer; Cotugno, Roberta; Tommasi, Nunziatina De; Braca, Alessandra

doi:10.1055/s-0033-1350648

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Its high-molecular-weight subfraction induced nitrous oxide and cytokine, TNF, granulocyte macrophage-colony stimulating factor, peripheral blood mononuclear cells, and monocytes with other wide-ranging agonist activities that considerably reduced disease severity ( 117 , 118 ). Four clerodane diterpenes and phenyl propanoids from aerial parts showed antiproliferative activity ( 119 ).…”

Section: Medicinal Plants Exhibiting Immunomodulation Activitymentioning

confidence: 99%

Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19

et al. 2021

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Plants have been extensively studied since ancient times and numerous important chemical constituents with tremendous therapeutic potential are identified. Attacks of microorganisms including viruses and bacteria can be counteracted with an efficient immune system and therefore, stimulation of body’s defense mechanism against infections has been proven to be an effective approach. Polysaccharides, terpenoids, flavonoids, alkaloids, glycosides, and lactones are the important phytochemicals, reported to be primarily responsible for immunomodulation activity of the plants. These phytochemicals may act as lead molecules for the development of safe and effective immunomodulators as potential remedies for the prevention and cure of viral diseases. Natural products are known to primarily modulate the immune system in nonspecific ways. A number of plant-based principles have been identified and isolated with potential immunomodulation activity which justify their use in traditional folklore medicine and can form the basis of further specified research. The aim of the current review is to describe and highlight the immunomodulation potential of certain plants along with their bioactive chemical constituents. Relevant literatures of recent years were searched from commonly employed scientific databases on the basis of their ethnopharmacological use. Most of the plants displaying considerable immunomodulation activity are summarized along with their possible mechanisms. These discussions shall hopefully elicit the attention of researchers and encourage further studies on these plant-based immunomodulation products as potential therapy for the management of infectious diseases, including viral ones such as COVID-19.

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Section: Medicinal Plants Exhibiting Immunomodulation Activitymentioning

confidence: 99%

Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19

et al. 2021

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“…Scientific research on this species allowed to isolate and identify four new clerodane diterpenoids, namely 2α-acetoxy-3β-(2′,3′-diacetoxy-2′-methyl)-butanoyloxy-14-hydro-15-hydroxyclerodin (74) , 3β,15-dihydroxy-14-hydro-clerodin (75) , 2α,15-dihydroxy-3β-(2′-hydroxy-2′-methyl-3′-acetoxy)-butanoyloxy-6α,18-diacetoxy-4α,17-epoxy-clerodan-11,16-lactone (76) and 3β,14S,15-trihydroxy-6α,18-diacetoxy-4α,17-epoxy-clerodan-11,16-lactone (77) [ 91 ]. The extraction method used for the phytochemical analyses of this plant species is shown in Table 10 .…”

Section: A Review Of Diterpenoid Compounds Isolated From Cl...mentioning

confidence: 99%

“…The results indicate that 2α-acetoxy-3β-(2′,3′-diacetoxy-2′-methyl)-butanoyloxy-14-hydro-15-hydroxyclerodin (74) and 2α,15-dihydroxy-3β-(2′-hydroxy-2′-methyl-3′-acetoxy)-butanoyloxy-6α,18-diacetoxy-4α,17-epoxy-clerodan-11,16-lactone (76) exhibit cell growth inhibition activity. In addition, the IC 50 values for the two compounds, viz., (76) and (74) , were found to be 101 μM and 98 μM, respectively, after 72 h incubation [ 91 ].…”

Section: A Review Of Diterpenoid Compounds Isolated From Cl...mentioning

confidence: 99%

Biologically Active Diterpenoids in the Clerodendrum Genus—A Review

Kuźma

Gomulski

2022

IJMS

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One of the key areas of interest in pharmacognosy is that of the diterpenoids; many studies have been performed to identify new sources, their optimal isolation and biological properties. An important source of abietane-, pimarane-, clerodane-type diterpenoids and their derivatives are the members of the genus Clerodendrum, of the Lamiaceae. Due to their diverse chemical nature, and the type of plant material, a range of extraction techniques are needed with various temperatures, solvent types and extraction times, as well as the use of an ultrasound bath. The diterpenoids isolated from Clerodendrum demonstrate a range of cytotoxic, anti-proliferative, antibacterial, anti-parasitic and anti-inflammatory activities. This review describes the various biological activities of the diterpenoids isolated so far from species of Clerodendrum with the indication of the most active ones, as well as those from other plant sources, taking into account their structure in terms of their activity, and summarises the methods for their extraction.

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“…The diterpenes from Callicarpa longissima (Liu et al , ), Clerodendrum splendens (Faiella et al , ), Fagonia mollis (Sallam et al , ), Icacina trichantha (Zhao et al , ), Hedychium longipetalum (Zhao et al , ), Micromonospora sp. (Mullowney et al , ), Cespitularia taeniata (Wang et al , ), Caesalpinia spinosa (He et al , ), Nephthea columnaris (Hsiao et al , ), Bursera microphylla (Messina et al , ), Teucrium viscidum (Gao et al , ), Euphorbia ebracteolata (Yuan et al , ), Euphorbia aellenii (Yazdiniapour et al , ), Perenniporia subacida (Wen et al , ), Abies fargesii (Wu et al , ) and Premna tomentosa (Rekha et al , ) were also evident to exert cytotoxic effects on a number of human cancer cell lines.…”

Section: Diterpenic Anticancer Traitsmentioning

confidence: 99%

Diterpenes and Their Derivatives as Potential Anticancer Agents

Islam

2017

Phytotherapy Research

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As therapeutic tools, diterpenes and their derivatives have gained much attention of the medicinal scientists nowadays. It is due to their pledging and important biological activities. This review congregates the anticancer diterpenes. For this, a search was made with selected keywords in PubMed, Science Direct, Web of Science, Scopus, The American Chemical Society and miscellaneous databases from January 2012 to January 2017 for the published articles. A total 28, 789 published articles were seen. Among them, 240 were included in this study. More than 250 important anticancer diterpenes and their derivatives were seen in the databases, acting in the different pathways. Some of them are already under clinical trials, while others are in the nonclinical and/or pre-clinical trials. In conclusion, diterpenes may be one of the lead molecules in the treatment of cancer. Copyright © 2017 John Wiley & Sons, Ltd.

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Diterpenes and Phenylpropanoids from Clerodendrum splendens

Cited by 4 publications

References 14 publications

Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19

Medicinal Plants and Isolated Molecules Demonstrating Immunomodulation Activity as Potential Alternative Therapies for Viral Diseases Including COVID-19

Biologically Active Diterpenoids in the Clerodendrum Genus—A Review

Diterpenes and Their Derivatives as Potential Anticancer Agents

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