Diterpene from marine brown alga Dictyota friabilis as a potential microbicide against HIV-1 in tissue explants

Stephens, Paulo Roberto Soares; Cirne-Santos, Cláudio César; Barros, Caroline de Souza; Teixeira, Valéria Laneuville; Carneiro, Leila Abboud Dias; Amorim, Leonardo dos Santos Corrêa; Ocampo, J.S.P.; Castello-Branco, L.R.R.; Paixão, Izabel Christina Nunes de Palmer

doi:10.1007/s10811-016-0925-1

Cited by 17 publications

(11 citation statements)

References 31 publications

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“…363 Pretreatment of peripheral blood cells and macrophages with dolabelladienetriol led to the inhibition of HIV-1 replication. 364 The monoacylglyceride, monoolein and the carotenoid metabolite apo-9 0 -fucoxanthinone have been shown to possess anti-inammatory activity. 365,366 The polyphenol, 6,6 0 -bieckol, shows angiotensin I-converting enzyme (ACE) inhibition leading to antihypertensive activity in rats.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2019

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Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2019

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“…Three antiviral diterpenes, named dolabelladienols A–C ( 10 6 – 10 8 ), were found from the same species, collected from Atol das Rocas, Northeast Brazil [ 46 ]. Compound 10 3 showed potent anti-HIV-1 effect ranging from 60% to 90% in peripheral blood cells (PBMC) and macrophages infected with the human immunodeficiency virus (HIV) from 60% to 90%, respectively [ 56 ]. This compound also exhibited moderate inhibition against herpes virus at a concentration of 50 μM, and it was found to be moderately active against HIV-1 reverse transcriptase activity at a concentration of 40 μM [ 57 ].…”

Section: Diterpenes Of Group 1imentioning

confidence: 99%

Diterpenes from the Marine Algae of the Genus Dictyota

Chen

Zhao

et al. 2018

Marine Drugs

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Species of the brown algae of the genus Dictyota are rich sources of bioactive secondary metabolites with diverse structural features. Excellent progress has been made in the discovery of diterpenes possessing broad chemical defensive activities from this genus. Most of these diterpenes exhibit significant biological activities, such as antiviral, cytotoxic and chemical defensive activities. In the present review, we summarized diterpenes isolated from the brown algae of the genus.

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“…Dolabelladienetriol from brown alga Dictyota spp has also been evaluated as a potential microbicide against HIV-1 in tissue explants. Namely, Stephens et al examined the 8,10,18-trihydroxy-2,6-dolabelladiene ( 41 , Figure 17) in pretreated peripheral blood cells (PBMC) and macrophages along with their protective effect in the ex vivo explant model of the uterine cervix [104]. Pre-treatment of peripheral PBMC and macrophages with dolabelladienotriol showed inhibitory effects on HIV-1 replication.…”

Section: Marine Compounds In the Treatment Of Hiv/aidsmentioning

confidence: 99%

Novel Antiretroviral Structures from Marine Organisms

et al. 2019

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In spite of significant advancements and success in antiretroviral therapies directed against HIV infection, there is no cure for HIV, which scan persist in a human body in its latent form and become reactivated under favorable conditions. Therefore, novel antiretroviral drugs with different modes of actions are still a major focus for researchers. In particular, novel lead structures are being sought from natural sources. So far, a number of compounds from marine organisms have been identified as promising therapeutics for HIV infection. Therefore, in this paper, we provide an overview of marine natural products that were first identified in the period between 2013 and 2018 that could be potentially used, or further optimized, as novel antiretroviral agents. This pipeline includes the systematization of antiretroviral activities for several categories of marine structures including chitosan and its derivatives, sulfated polysaccharides, lectins, bromotyrosine derivatives, peptides, alkaloids, diterpenes, phlorotannins, and xanthones as well as adjuvants to the HAART therapy such as fish oil. We critically discuss the structures and activities of the most promising new marine anti-HIV compounds.

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Diterpene from marine brown alga Dictyota friabilis as a potential microbicide against HIV-1 in tissue explants

Cited by 17 publications

References 31 publications

Marine natural products

Marine natural products

Diterpenes from the Marine Algae of the Genus Dictyota

Novel Antiretroviral Structures from Marine Organisms

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