Disulfide-cross-linked PEG-block-polypeptide nanoparticles with high drug loading content as glutathione-triggered anticancer drug nanocarriers

Chen, Yu Fon; Chang, Chien Hsiang; Lin, Ching Yu; Lin, Li Fang; Yeh, Ming Lung; Jan, Jeng‐Shiung

doi:10.1016/j.colsurfb.2018.02.042

Cited by 25 publications

(9 citation statements)

References 33 publications

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“…And it was much easier for positively charged particles to penetrate into the tumor cells [44]. On the other hand, after entering the tumor, the disulfide bonds-employing micelles could disassemble rapidly and release the drug effectively under a high level of GSH [45,46]. In contrast, they were stable at normal physiologic conditions, and this would reduce the toxicity to the body.…”

Section: In Vivo Antitumor Efficacymentioning

confidence: 99%

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

et al. 2020

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In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.

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Section: In Vivo Antitumor Efficacymentioning

confidence: 99%

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

et al. 2020

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“…Recently, polypeptides and their derivatives have attracted much attention and are widely used for antibacterial materials, , antifouling coating, drug and gene delivery, − adhesives, and dressings . Especially, polypeptides offer considerable chemical diversity just through the combination of 20 typical amino acids .…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic Graft Copolymer of Polylysine-g-polytetrahydrofuran and Its Biological Properties

Chen

Cui

Gao

et al. 2022

ACS Appl. Polym. Mater.

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The graft copolymer of poly-(N-ε-carbobenzyloxy-Llysine)-g-poly(tetrahydrofuran) (PZLL-g-PTHF) could be successfully synthesized via the nucleophilic substitution reaction of PTHF + living polymer chains with secondary amine side groups in the PZLL backbone. The amphiphilic graft copolymers of polylysine-g-poly(tetrahydrofuran) (PLL-g-PTHF) could be obtained by complete deprotection of the precursor of PZLL-g-PTHF. The obvious microphase separation was observed in both PLL-g-PTHF and PZLL-g-PTHF because of the incompatibility between the two kinds of segments. Their micromorphology is dependent on the chemical structure of backbones and the grafting number (G N ) of branches. PZLL-g-PTHF is a hydrophobic graft copolymer and the water contact angles (WCAs) of copolymer surfaces decreased from 103 to 91°with the increase of G N from 5 to 21. Interestingly, PLL-g-PTHF is an amphiphilic graft copolymer and their WCAs increased from 52 to 90°with the increase of G N from 5 to 21. Both PZLL-g-PTHF and PLL-g-PTHF copolymers show good biocompatibility and anti-protein adsorption. The resulting PZLL-g-PTHF copolymers carrying a small amount of Ag nanoparticles, in situ generated from coinitiator AgClO 4 for the synthesis of PTHF + living chains, exhibit high killing efficiency (>95%) for both Escherichia coli and Staphylococcus aureus. PLL-g-PTHF/Ag nanocomposites show extremely high killing efficiency (>99%) against both S. aureus and E. coli for binary contribution from Ag nanoparticles and PLL. The antifouling and antibacterial graft copolymers would potentially have biological and medical applications.

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“…While, when they arrive at the tumor site, the disulfide links can be cleaved rapidly upon exposure to the high level of GSH, and this leads to the immediate release of the drug. 19,20 Undoubtedly, micelles with disulfide bonds in the molecules are promising candidates for controlled drug release in the tumor, which may have enhanced anticancer activity and reduced systemic toxicity.…”

Section: Introductionmentioning

confidence: 99%

Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel

Liu

Liang

et al. 2020

J Biomater Appl

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The clinical application of paclitaxel is limited due to its low solubility and severe side effects. A tumor-targeting and redox-sensitive paclitaxel-loaded micellar system could exhibit high drug solubility, excellent antitumor activity and low toxicity to normal tissues. An mPEG and hexadecanol-modified hyaluronic acid with disulfide bridges in the molecules (mPEG-S-S-HA-C16) was designed and synthesized. Using mPEG-S-S-HA-C16 as the carrier, the paclitaxel-loaded micelles were fabricated, and their physicochemical properties were studied deeply. Moreover, the antitumor evaluation of the paclitaxel-loaded micelles was conducted in vitro and in vivo. For the optimized paclitaxel-loaded mPEG-S-S-HA-C16 micelles, the average size and zeta potential were 168.6 nm and À38.2 mV, respectively. In vitro drug release study demonstrated the redox-sensitivity of the micelles that the encapsulated paclitaxel could be released rapidly in the presence of glutathione. MTT assay confirmed the low toxicity of the polymeric material itself and the excellent cytotoxicity of paclitaxel-loaded mPEG-S-S-HA-C16 micelles against MCF-7 cells. Moreover, the in vivo antitumor evaluation demonstrated the superior antitumor efficacy of the paclitaxel-loaded micelles. These results suggested that the paclitaxel-loaded mPEG-S-S-HA-C16 micelles held great promise for targeted delivery of paclitaxel.

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Disulfide-cross-linked PEG-block-polypeptide nanoparticles with high drug loading content as glutathione-triggered anticancer drug nanocarriers

Cited by 25 publications

References 33 publications

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

Amphiphilic Graft Copolymer of Polylysine-g-polytetrahydrofuran and Its Biological Properties

Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel

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