Disturbances of septohippocampal theta oscillations in the epileptic brain: Reasons and consequences

Decreased vesicular acetylcholine transporter related to memory deficits in epilepsy: A [18F] VAT positron emission tomography brain imaging study

“…The death of septal neurons may contribute to network rewiring. This could result in disturbance of theta oscillations, which play a key role in cognitive function . Contrary to our results, in dementia with Lewy bodies, 123 I‐iodobenzovesamicol single photon emission computed tomography scan of VAChT demonstrated significantly lower nondisplaceable binding potential values in the Ch4 and Ch5 pathway both at cortical and subcortical levels, whereas the Ch1 pathway was relatively preserved .…”

“…In our study, decline of VAChT in the epilepsy group and a positive correlation between VAChT level and memory function were found in most sectors of cholinergic pathway, which indicates a crucial role of cholinergic dysfunction in epilepsy‐associated cognitive deficits. Our results suggest that all of the Ch1‐Ch6 pathways were affected and the most obviously disturbed was Ch1 and Ch2, representing a septohippocampal network, in which cholinergic neurons participate in the generation of theta oscillations . In chronic epilepsy, the septohippocampal network is altered .…”

“…Our results suggest that all of the Ch1-Ch6 pathways were affected and the most obviously disturbed was Ch1 and Ch2, representing a septohippocampal network, in which cholinergic neurons participate in the generation of theta oscillations. 30 In chronic epilepsy, the septohippocampal network is altered. 31 The death of septal neurons may contribute to network rewiring.…”

Functional Reduction in Cannabinoid-Sensitive Heterotypic Inhibition of Dentate Basket Cells in Epilepsy: Impact on Network Rhythms

“…Deficits in memory processing constitute a significant co-morbidity in epilepsy (Chauviere et al 2009;Kitchigina et al 2013). Inhibitory neuronal networks underlie brain rhythms which are crucial for memory formation (Wang 2010).…”

Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats

“…GABAergically-induced ectopic granule cells in the dentate gyrus during development in FS rats [29] ); and (2) a decrease in HCN (hyperpolarization-activated cyclic nucleotide-gated) channels, which are associated with hippocampal rhythms [31,32] , induced by FSs during epileptogenesis [30] . Here we found that the CA3 pyramidal neuronal cell body circumference occupied by inhibitory presynaptic terminals was significantly increased in FS rats at P35.…”