Disturbances of Phosphate Metabolism: Another Feature of Metabolic Syndrome

Kalaitzidis, Rigas; Tsimihodimos, Vasilis; Bairaktari, Eleni; Siamopoulos, K. C.; Elisaf, Moses

doi:10.1053/j.ajkd.2005.01.005

Cited by 61 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that HC participants and participants with TS had similar Pi-toPCr ratios and ATP, pH, and PCr levels, but participants with TS had lower resting Pi levels than HC subjects. Reduced resting Pi levels have been observed previously in research on metabolic syndrome and are suggested to be a major characteristic of the metabolic syndrome due to either reduced reabsorption or altered distribution between cellular compartments (28,29). The participants with TS did have higher blood pressures and lipid levels, so these features of the metabolic syndrome and lower Pi in the TS group is consistent with other literature on this topic.…”

Section: Discussionsupporting

confidence: 80%

Skeletal Muscle Abnormalities in Girls and Adolescents With Turner Syndrome

Wells

O’Gorman

Rayner

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context:Turner syndrome (TS) is a chromosomal disorder occurring in approximately 1 in 2500 live births. Individuals with TS report lower levels of physical activity than healthy control (HC) subjects. Cardiorespiratory limitations may contribute to the observed reduction in physical activity.Objective: The objective of this study was to compare muscle metabolism of patients with TS vs HC subjects before and after exercise using exercise testing, magnetic resonance imaging, and magnetic resonance spectroscopy techniques. Design:We hypothesized that girls and adolescents with TS would have muscle metabolic abnormalities not present in the HC population. Setting:The research was conducted at the Hospital for Sick Children in Toronto, Ontario, Canada.Participants: Fifteen participants with TS were age-, activity-, and body mass index Z-scorematched with 16 HC subjects. Main Outcome Measures:31 P magnetic resonance spectroscopy was used to characterize muscle metabolism at rest and after 30 seconds of high-intensity exercise, 60 seconds of moderate-intensity exercise, and 5 minutes of low-intensity exercise.Results: While achieving the same workloads, participants with TS exhibited a greater difference between rest and end-exercise pH compared with HC subjects after 30 seconds (TS, 0.29 Ϯ 0.04; HC, 0.21 Ϯ 0.08; P ϭ .03) and 90 seconds (TS, 0.47 Ϯ 0.22; HC, 0.32 Ϯ 0.13; P ϭ .02) of exercise. During the 5-minute exercise test, similar workloads were achieved between groups; however, ATP production was greater in participants with TS vs the HC subjects via all 3 bioenergetic pathways (total ATP: TS, 0.90 Ϯ 0.34; HC, 0.60 Ϯ 0.25; P ϭ .01). Conclusions:The results of this study suggest that patients with TS exhibit greater anaerobic stress during exercise than HC subjects, which may lead to symptoms of increased muscle fatigue with short bursts of activity. Recovery metabolism after exercise appears to be similar between participants with TS and HC subjects, which is suggestive of normal mitochondrial metabolism and oxygen transport. (J Clin Endocrinol Metab 98:

show abstract

Section: Discussionsupporting

confidence: 80%

Skeletal Muscle Abnormalities in Girls and Adolescents With Turner Syndrome

Wells

O’Gorman

Rayner

et al. 2013

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

show abstract

“…Therefore, insulin can modify the handling of UA by the kidney, thus leading to hyperuricemia. In the same context, we recently showed that patients with MetS exhibited significantly lower serum phosphate and magnesium levels compared with healthy individuals [50].…”

Section: Direct Association Of Sua Levels With Mets and Irmentioning

confidence: 95%

Elevated serum uric acid levels in metabolic syndrome: an active component or an innocent bystander?

et al. 2006

View full text Add to dashboard Cite

“…Phosphorus infusion to healthy volunteers improves insulin sensitivity under euglycemic conditions [20] , and phosphorus supplementation for hypophosphatemic patients with glucose intolerance ameliorates glucose tolerance [21] . Therefore, a reduction in phosphate levels may decrease the peripheral utilization of glucose, thus, leading to the development of insulin resistance, a major determinant of MetS [4] .…”

Section: Discussionmentioning

confidence: 99%